Imperial College London
Alternate

DrPaoloMontaldo

Faculty of Medicine, Department of Brain Sciences

Honorary Research Fellow
 
 
 
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Contact

 

p.montaldo

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chalak:2018:10.1038/s41390-018-0174-x,
author = {Chalak, LF and Nguyen, K-A and Prempunpong, C and Heyne, R and Thayyil, S and Shankaran, S and Laptook, AR and Rollins, N and Pappas, A and Koclas, L and Shah, B and Montaldo, P and Techasaensiri, B and Sánchez, PJ and Sant'Anna, G},
doi = {10.1038/s41390-018-0174-x},
journal = {Pediatric Research},
pages = {861--868},
title = {Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months},
url = {http://dx.doi.org/10.1038/s41390-018-0174-x},
volume = {84},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking. OBJECTIVE: To evaluate neurodevelopmental outcomes at 18-22 months of PRIME study. STUDY DESIGN: Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70-84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70-84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3-5. RESULTS: Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001). CONCLUSIONS: In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18-22 months.
AU  - Chalak,LF
AU  - Nguyen,K-A
AU  - Prempunpong,C
AU  - Heyne,R
AU  - Thayyil,S
AU  - Shankaran,S
AU  - Laptook,AR
AU  - Rollins,N
AU  - Pappas,A
AU  - Koclas,L
AU  - Shah,B
AU  - Montaldo,P
AU  - Techasaensiri,B
AU  - Sánchez,PJ
AU  - Sant'Anna,G
DO  - 10.1038/s41390-018-0174-x
EP  - 868
PY  - 2018///
SN  - 0031-3998
SP  - 861
TI  - Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months
T2  - Pediatric Research
UR  - http://dx.doi.org/10.1038/s41390-018-0174-x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30250303
UR  - http://hdl.handle.net/10044/1/63957
VL  - 84
ER  -
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