504 results found
Nihoyannopoulos P, British Cardiovascular Society 2016, Petros Nihoyannopoulos
Bechman K, Gopalan D, Nihoyannopoulos P, et al., 2017, A cohort study reveals myocarditis to be a rare and life-threatening presentation of large vessel vasculitis., Semin Arthritis Rheum, Vol: 47, Pages: 241-246
BACKGROUND: The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly secondary to uncontrolled arterial hypertension or myocardial ischaemia. Pulmonary hypertension and aortic valve incompetence following ascending aortic dilatation represent other serious cardiovascular complications. However, cardiac failure as a consequence of myocarditis is rarely reported, principally in single case reports or in autopsy studies. METHODS: The Imperial College LVV database was, retrospectively, reviewed to identify patients with cardiac involvement at presentation. Patients with evidence for myocarditis were identified. The cardiac presentation, imaging studies and subsequent medical and surgical management were reviewed in detail. RESULTS: The cohort included 139 patients with TA and 24 with GCA. Sixteen presented with cardiac failure without a history of ischaemic coronary heart disease, 14 (10%) with TA and 2 (8.3%) with GCA. Cardiovascular disease identified at presentation included aortic regurgitation (n = 11), myocarditis (n = 4) and hypertensive cardiomyopathy secondary to renal artery stenosis (n = 1). Those patients with evidence of myocarditis at presentation (2.8%) underwent transthoracic echocardiography and cardiac magnetic resonance imaging (CMR). These non-invasive techniques were sufficient for diagnosis of clinically significant myocarditis. Furthermore, they were subsequently used to monitor response to treatment, with serial improvement in left ventricular ejection fraction (LVEF) observed in all 4 patients (p < 0.05). Prednisolone plus cyclophosphamide (CyC) therapy was associated with significant improvement in heart failure symptoms and LVEF in 3 cases. In one case where CyC was contraindicated, tocilizumab treatment led to marked improvement in cardiac symptoms. CONCLUSION
Colclough A, Nihoyannopoulos P, 2017, Pocket-sized point-of-care cardiac ultrasound devices Role in the emergency department, HERZ, Vol: 42, Pages: 255-261, ISSN: 0340-9937
Kadoglou NPE, Biddulph JP, Rafnsson SB, et al., 2017, The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing, PLOS ONE, Vol: 12, ISSN: 1932-6203
Keramida K, Bingcang J, Wensel R, et al., 2017, Assessment of trastuzumab effect on both ventricles by 2D speckle tracking analysis, Publisher: WILEY, Pages: 261-261, ISSN: 1388-9842
Luis Zamorano J, Lancellotti P, Rodriguez Munoz D, et al., 2017, 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC), EUROPEAN JOURNAL OF HEART FAILURE, Vol: 19, Pages: 9-42, ISSN: 1388-9842
Rehman MB, Howard LS, Christiaens LP, et al., 2017, Resting right ventricular function is associated with exercise performance in PAH, but not in CTEPH., Eur Heart J Cardiovasc Imaging
Aims: To assess whether resting right ventricular (RV) function assessed by Global RV longitudinal strain (RVLS) and RV fractional area change (FAC) is associated with exercise performance in pulmonary arterial hypertension (PAH) and in chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results: We prospectively recruited 46 consecutive patients with PAH and 42 patients with CTEPH who were referred for cardio-pulmonary exercise testing (CPET) and transthoracic echocardiography. Resting RV systolic function was assessed with RVLS and FAC. CPET parameters analyzed were percentage of predicted maximal oxygen consumption (VO2max) and the slope of ventilation against carbon dioxide production (VE/VCO2). Spearman correlation was performed between echocardiographic measurements and CPET measurements. In PAH, spearman correlation found an association between RVLS and VE/VCO2 (coefficient = 0.556, P < 0.001) and percentage predicted VO2max (coefficient = -0.393, P = 0.007), while FAC was associated with VE/VCO2 (coefficient = -0.481, P = 0.001) and percentage of predicted VO2max (coefficient = 0.356, P = 0.015). Conversely, in CTEPH, resting RV function was neither associated with percentage of predicted VO2max nor with VE/VCO2, whether assessed by RVLS or FAC. Conclusion: In PAH, resting RV function as assessed by FAC or RVLS is associated with exercise performance and could therefore make a significant contribution to non-invasive assessment in PAH patients. This association is not found in CTEPH, suggesting a disconnection between resting RV function and exercise performance, with implications for the use of exercise measurements as a prognostic marker and clinical/research endpoint in CTEPH.
Steeds RP, Garbi M, Cardim N, et al., 2017, EACVI appropriateness criteria for the use of transthoracic echocardiography in adults: a report of literature and current practice review., Eur Heart J Cardiovasc Imaging
The European Association for Cardiovascular Imaging (EACVI) has outlined the rationale for setting appropriate use criteria (AUC) in cardiovascular (CV) imaging. Transthoracic echocardiography (TTE) is the most common imaging modality in CV disease and is a central tool in diagnosis, follow-up, management planning and intervention. The purpose of AUC is to inform referrers, both to avoid under-use, which may result in incomplete or incorrect diagnosis and treatment, and also over-use, which may delay correct diagnosis, lead to 'treatment cascade', and wastes resources. The first step in defining AUC for TTE in the adult has been for a panel of experts in echocardiography to review the evidence, guidelines, recommendations, and position papers from the European Society of Cardiology, EACVI and other specialist societies, and current state-of-the-art clinical practice. The attached document summarizes this work, which will be used to under-pin the development of AUC.
Sulemane S, Panoulas VF, Bratsas A, et al., 2017, Subclinical markers of cardiovascular disease predict adverse outcomes in chronic kidney disease patients with normal left ventricular ejection fraction, INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol: 33, Pages: 687-698, ISSN: 1569-5794
Sulemane S, Panoulas VF, Nihoyannopoulos P, 2017, Echocardiographic assessment in patients with chronic kidney disease: Current update, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, Vol: 34, Pages: 594-602, ISSN: 0742-2822
Agelaki M, Bhatti Y, Grapsa J, et al., 2016, Significant reverse atrial remodelling demonstrated with 3D strain in patients with paroxysmal atrial fibrillation who are undergoing early ablation, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 655-656, ISSN: 0195-668X
Georgiopoulos G, Katsi V, Oikonomou D, et al., 2016, Azilsartan as a Potent Antihypertensive Drug with Possible Pleiotropic Cardiometabolic Effects: A Review Study, Frontiers in Pharmacology, Vol: 7, ISSN: 1663-9812
Grapsa J, Tan TC, Durighel G, et al., 2016, INTERVENTRICULAR SEPTAL DISPLACEMENT WITHIN THE CARDIAC CYCLE PREDICTS MORTALITY IN PATIENTS WITH PRE-CAPILLARY PULMONARY HYPERTENSION, 65th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: 2077-2077, ISSN: 0735-1097
Grapsa J, Tan TC, Howard LSGE, et al., 2016, Regression of RV mass and interventricular septal curvature duration predict mortality in patients with pre-capillary pulmonary hypertension: a follow up study, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 1187-1187, ISSN: 0195-668X
Habib G, Lancellotti P, Antunes MJ, et al., 2016, [2015 ESC Guidelines for the management of infective endocarditis. The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)]., G Ital Cardiol (Rome), Vol: 17, Pages: 277-319, ISSN: 1827-6806
Habib G, Lancellotti P, Antunes MJ, et al., 2016, Guía ESC 2015 sobre el tratamiento de la endocarditis infecciosa, Revista Espanola de Cardiologia, Vol: 69, Pages: 69e1-69e49, ISSN: 0300-8932
Katsi VK, Pavlidis AN, Liakos CI, et al., 2016, The Tree of Sirtuins and the Garden of Cardiovascular Youth, CURRENT VASCULAR PHARMACOLOGY, Vol: 14, Pages: 80-87, ISSN: 1570-1611
Keramida K, Kouris N, Olympios CD, et al., 2016, Systolic performance of the left ventricle after myocardial infarction. The absence of ST elevation costs myocardium, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 18, Pages: 421-421, ISSN: 1388-9842
Oikonomou E, Nihoyannopoulos P, 2016, Do we really need novel echocardiographic modalities to confirm the superiority of the intact His-Purkinje conduction system over pacing modes?, Hellenic J Cardiol, Vol: 57, Pages: 178-180
Panoulas V, Thyregod HG, Nihoyannopoulos P, et al., 2016, Increased survival of females with severe aortic stenosis after transcatheter aortic valve implantation compared to surgical aortic valve replacement; a meta-analysis of randomised controlled studies, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 72-72, ISSN: 0195-668X
Panoulas VF, Ruparelia N, Franks R, et al., 2016, The Impact of Gender on Outcomes Following Transcatheter Aortic Valve Implantation: True Effect or Bias?, J Heart Valve Dis, Vol: 25, Pages: 552-556, ISSN: 0966-8519
Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for patients with severe aortic stenosis (AS) who are unsuitable for surgical aortic valve replacement (SAVR), and is an acceptable alternative for those at high and intermediate surgical risk. In published TAVI registries and meta-analyses, whilst women are significantly older they present with fewer comorbidities compared to men (including coronary artery disease, peripheral vascular disease, diabetes and chronic obstructive pulmonary disease). In response to chronic pressure overload from AS, women have been shown to develop greater levels of left ventricular hypertrophy than men, as well as having a greater preservation of LV ejection fraction (LVEF) and less fibrosis. Following aortic valve replacement, women have been shown to have a faster regression of myocardial hypertrophy, with a significant improvement in LVEF. Following TAVI, female gender seems to be associated with a significantly lower one-year mortality. In the current viewpoint, it is discussed whether these findings reflect a true differential treatment response to TAVI among women, or simply the higher comorbidity burden among males undergoing TAVI.
Ponikowski ADGDTP, Voors AA, Anker SD, et al., 2016, Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica, Revista Espanola de Cardiologia, Vol: 69, Pages: 1167.e1-1167.e85, ISSN: 0300-8932
Ponikowski P, Voors AA, Anker SD, et al., 2016, 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 18, Pages: 891-975, ISSN: 1388-9842
Ponikowski P, Voors AA, Anker SD, et al., 2016, 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure, EUROPEAN HEART JOURNAL, Vol: 37, Pages: 2129-U130, ISSN: 0195-668X
Seraphim A, Paschou SA, Grapsa J, et al., 2016, Pocket-sized echocardiography devices: one stop shop service?, Journal of Cardiovascular Ultrasound, Vol: 24, Pages: 1-6, ISSN: 2005-9655
The introduction of portable, pocket-sized echocardiography devices in various healthcare systems has raised new questions with regards to their realistic use in clinical practice. Several studies have already attempted to provide information regarding their safety and diagnostic potential, the training required to operate them, as well as their direct comparison with standard echocardiography machines. This manuscript is a review of the literature of the documents or position papers which employ the use of pocket or handheld devices. Following review of the literature, we suggest that these miniaturized devices can provide a valuable diagnostic tool that can complement and improve the diagnostic yield of clinical examination. When operated by appropriately trained professionals, they can provide a limited but very reliable echocardiographic assessment. Pocket-sized echocardiography is a part of physical examination and should not be considered a complete echocardiographic scan. Optimal training is required for the smooth operation of handheld echocardiography.
Sulemane S, Panoulas VF, Konstantinou K, et al., 2016, Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease (vol 14, pg 10, 2016), CARDIOVASCULAR ULTRASOUND, Vol: 14, ISSN: 1476-7120
Sulemane S, Panoulas VF, Konstantinou K, et al., 2016, Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease, CARDIOVASCULAR ULTRASOUND, Vol: 14, ISSN: 1476-7120
Vrettos A, Dawson D, Grigoratos C, et al., 2016, Correlation between global longitudinal peak systolic strain and coronary artery disease severity as assessed by the angiographically derived SYNTAX score, ECHO RESEARCH AND PRACTICE, Vol: 3, Pages: 29-34, ISSN: 2055-0464
Zamorano JL, Lancellotti P, Munoz DR, et al., 2016, 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines, EUROPEAN HEART JOURNAL, Vol: 37, Pages: 2768-2801, ISSN: 0195-668X
Afilalo J, Grapsa J, Nihoyannopoulos P, et al., 2015, Leaflet Area as a Determinant of Tricuspid Regurgitation Severity in Patients With Pulmonary Hypertension, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 8, ISSN: 1941-9651
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