Publications
669 results found
Shaw LJ, Monaghan MJ, Nihoyannopoulos P, 1999, Clinical and economic outcomes assessment with myocardial contrast echocardiography, HEART, Vol: 82, Pages: 16-21, ISSN: 1355-6037
- Author Web Link
- Cite
- Citations: 17
Ikonomidis I, Andreotti F, Economou E, et al., 1999, Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin, CIRCULATION, Vol: 100, Pages: 793-798, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 443
Rallidis LS, Moyssakis IE, Ikonomidis I, et al., 1999, Natural history of early aortic paraprosthetic regurgitation: A five-year follow-up, AMERICAN HEART JOURNAL, Vol: 138, Pages: 351-357, ISSN: 0002-8703
- Author Web Link
- Cite
- Citations: 176
Moyssakis I, Triposkiadis F, Rallidis L, et al., 1999, Echocardiographic features of primary, secondary and familial amyloidosis, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 29, Pages: 484-489, ISSN: 0014-2972
- Author Web Link
- Cite
- Citations: 21
Zouridakis EG, Cox ID, Garcia-Moll X, et al., 1999, Dobutamine stress echocardiography and thallium scintigraphy in normotensive and hypertensive patients with angina pectoris, positive exercise electrocardiograms and normal coronary arteriograms, Heart, Vol: 81, ISSN: 1355-6037
Both hypertensive and normotensive patients may present with typical anginal pain despite normal coronary arteriograms (CPNA). Pathogenetic mechanisms involving microvascular ischaemia have been proposed in both groups; however, recent echocardiographic studies which failed to demonstrate regional myocardial dysfunction during stress in normotensive CPNA patients have led some investigators to question this hypothesis. Aim: To compare the results of dobutamine stress echocardiography (DSE) and thallium scintigraphy in two well-matched groups of hypertensive and normotensive patients with CPNA Methods: We studied 33 patients with typical exertional angina, a positive exercise electrocardiogram (ECG) and a completely normal coronary arteriogram. Seventeen patients had a history of systemic hypertension (14 women; mean age 57±6 years), and 16 patients had no hypertensive history (12 women; mean age 54±9 years). All patients had normal left ventricular systolic function and none had left ventricular hypertrophy. All patients underwent DSE and Thallium 201 SPECT according to a standard protocol. Results: Eight (50%) normotensive patients and 10 (59%) hypertensive patients had scintigraphic perfusion defects (p=0.61). Dobutamine infusion reproduced anginal pain in 7 (44%) normotensive and 7 (41%) hypertensive patients (p=0.88). Ischaemic ST-segment was also recorded in 8 (50%) normotensive and in 7 (41%) hypertensive patients (p=0.61). No patient in either group developed regional wall motion abnormalities during DSE. Conclusions: Although the concept of microvascular ischaemia is more widely accepted in hypertensive CPNA patients, this group do not seem more likely to develop regional wall motion abnormalities during dobutamine stress than their normotensive counterparts. These findings may indicate that DSE is relatively insensitive to ischaemia due to microvascular dysfunction or that significant ischaemia is not present in either group.
Rallidis L, Nihoyannopoulos P, Tsitouris G, et al., 1999, Aortic valve involvement in familial heterozygous hypercholesterolaemia: An echocardiographic study, ATHEROSCLEROSIS, Vol: 144, Pages: 141-141, ISSN: 0021-9150
Branco L, 1999, Accuracy and feasibility of contrast echocardiography for detection of perfusion defects in routine practice. Comparison with wall motion and technetium--99m sestamibi single--photon emission computed tomography., Rev Port Cardiol, Vol: 18, Pages: 415-416, ISSN: 0870-2551
Binder T, Assayag P, Baer F, et al., 1999, NC100100, a new echo contrast agent for the assessment of myocardial perfusion -: Safety and comparison with technetium-99m sestamibi single-photon emission computed tomography in a randomized multicenter study, CLINICAL CARDIOLOGY, Vol: 22, Pages: 273-282, ISSN: 0160-9289
- Author Web Link
- Cite
- Citations: 11
Dutka DP, Donnelly JE, Nihoyannopoulos P, et al., 1999, Marked variation in the cardiomyopathy associated with Friedreich's ataxia, HEART, Vol: 81, Pages: 141-147, ISSN: 1355-6037
- Author Web Link
- Cite
- Citations: 60
Rallidis LS, Nihoyannopoulos P, 1999, Role of dobutamine stress echocardiography early after an acute myocardial infarction, Hellenic Journal of Cardiology, Vol: 40, Pages: 186-196, ISSN: 1011-7970
Dobutamine stress echocardiography (DSE) is a simple non-invasive technique providing valuable information on resting function, myocardial viability and active ischaemia after an acute uncomplicated myocardial infarction, DSE can be performed safely before patient's discharge with the addition of atropine if maximal heart rate is <120 bpm. Regarding the induction of ischaemia DSE has a place if the traditional exercise electrocardiography is non-diagnostic. Compared to exercise electrocardiography DSE offers the ability to determine the site of ischaemia and distinguish between peri-infarct and remote ischaemia. Remote ischaemia indicates multivessel coronary artery disease and carries a higher risk for future cardiac events than peri-infarct ischaemia. The evaluation for viability early after a myocardial infarction is mandatory in the presence of severely impaired left ventricle since documentation of viability can improve dramatically prognosis after successful revascularization.
Nihoyannopoulos P, 1999, The role of echocardiography in diagnosis and management of cardiac syndrome X, Chest pain with normal coronary angiograms. Pathogenesis, diagnosis and management, Editors: Kaski, Publisher: Kluer, Pages: 171-180
Calachanis M, Evdoridis C, Nihoyannopoulos P, 1999, Improved diagnostic accuracy of dobutamine stress echocardiography with Echogen, Cardiovasc Imag, Vol: 11
Cokkinos P, Nihoyannopoulos P, 1999, Diagnosis and pitfalls: Hypertrophic cardiomyopathy, Quarterly Journal of Cardiology, Vol: 1
Rallidis L, Naoumova RR, Thompson GR, et al., 1998, Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia, HEART, Vol: 80, Pages: 583-590, ISSN: 1355-6037
- Author Web Link
- Cite
- Citations: 81
Cheesman MG, Leech G, Chambers J, et al., 1998, Central role of echocardiography in the diagnosis and assessment of heart failure, HEART, Vol: 80, Pages: S1-S5, ISSN: 1355-6037
- Author Web Link
- Cite
- Citations: 8
Marwick TH, Brunken R, Meland N, et al., 1998, Accuracy and feasibility of contrast echocardiography for detection of perfusion defects in routine practice: comparison with wall motion and technetium-99m sestamibi single-photon emission computed tomography. The Nycomed NC100100 Investigators., J Am Coll Cardiol, Vol: 32, Pages: 1260-1269, ISSN: 0735-1097
OBJECTIVES: We sought to assess the feasibility and accuracy of myocardial contrast echocardiography (MCE) using standard imaging approaches for the detection of perfusion defects in patients who had a myocardial infarction (MI). BACKGROUND: Myocardial contrast echocardiography may be more versatile than perfusion scintigraphy for identifying the presence and extent of perfusion defects after MI. However, its reliability in routine practice is unclear. METHODS: Fundamental or harmonic MCE was performed with continuous or triggered imaging in 203 patients with a previous MI using bolus doses of a perfluorocarbon-filled contrast agent (NC100100). All patients underwent single-photon emission computed tomography (SPECT) after the injection of technetium-99m (Tc-99m) sestamibi at rest. Quantitative and semiquantitative SPECT, wall motion and digitized echocardiographic data were interpreted independently. The accuracy of MCE was assessed for detection of segments and patients with moderate and severe sestamibi-SPECT defects, as well as for detection of patients with extensive perfusion defects (>12% of left ventricle). RESULTS: In segments with diagnostic MCE, the segmental sensitivity ranged from 14% to 65%, and the specificity varied from 78% to 95%, depending on the dose of contrast agent. Using both segment- and patient-based analysis, the greatest accuracy and proportion of interpretable images were obtained using harmonic imaging in the triggered mode. For the detection of extensive defects, the sensitivity varied from 13% to 48%, with specificity from 63% to 100%. Harmonic imaging remained the most accurate approach. Time since MI and SPECT defect location and intensity were all determinants of the MCE response. The extent of defects on MCE was less than the extent of either abnormal wall motion or SPECT abnormalities. The combination of wall motion and MCE assessment gave the best balance of sensitivity (46% to 55%) and specificity (82% to 83%). CONCLUSIONS:
Nihoyannopoulos P, 1998, Stress echocardiography in the community, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 1599-1601, ISSN: 0195-668X
Cheesman MG, Leech G, Chambers J, et al., 1998, Central role of echocardiography in the diagnosis and assessment of heart failure. British Society of Echocardiography., Heart, Vol: 80 Suppl 1, Pages: S1-S5, ISSN: 1355-6037
Ikonomidis I, Stefanades C, Economou E, et al., 1998, Low dose aspirin reduces elevated C-reactive protein plasma levels in patients with chronic stable angina by reducing cytokine plasma levels., CIRCULATION, Vol: 98, Pages: 563-563, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 1
Palka P, Lange A, Donnelly JE, et al., 1998, Myocardial velocity gradient - A new accurate echocardiographic indicator of cardiac amyloidosis, CIRCULATION, Vol: 98, Pages: 784-785, ISSN: 0009-7322
Rallidis LS, Moyssakis IE, Nihoyannopoulos P, 1998, Hypotensive response during dobutamine stress echocardiography in coronary patients: A common event of well-functioning left ventricle, CLINICAL CARDIOLOGY, Vol: 21, Pages: 747-752, ISSN: 0160-9289
- Author Web Link
- Cite
- Citations: 11
Stangou AJ, Hawkins PN, Heaton ND, et al., 1998, Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy - Implications for amyloid fibrillogenesis, TRANSPLANTATION, Vol: 66, Pages: 229-233, ISSN: 0041-1337
- Author Web Link
- Cite
- Citations: 162
Nihoyannopoulos P, Zamorano J, 1998, Applications of contrast in echocardiography, REVISTA ESPANOLA DE CARDIOLOGIA, Vol: 51, Pages: 428-434, ISSN: 1885-5857
- Author Web Link
- Cite
- Citations: 4
Nihoyannopoulos P, Zamorano J, 1998, [Applications of contrast media in echocardiography]., Rev Esp Cardiol, Vol: 51, Pages: 428-434, ISSN: 0300-8932
The development of contrast media in ultrasound has been slow and sporadic, and there are no fully satisfactory agents for clinical imaging to date. Most contrast agents consist of air filled microbubbles which generate scattered echoes and enhance the ultrasound information. In this article we review the different phases of contrast echocardiography their potentials and clinical applications. First, right-sided echocontrast which is mainly used for the assessment of intracardiac shunts. Second, left-sided contrast agents with smaller and more stable microbubbles, that allow the visualization of the left ventricle after intravenous injection. With these agents, one it is now possible to study myocardial perfusion which is one of the most attractive potentials of these types of agents.
Nihoyannopoulos P, Hawkins P, 1998, Hereditary cardiac amyloidosis, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 686-688, ISSN: 0195-668X
- Author Web Link
- Cite
- Citations: 3
Ikonomidis I, Andreotti F, Stefanadis C, et al., 1998, Increased cytokine levels and thrombin generation in stable angina are reduced by aspirin. A randomised, controlled, cross-over trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 16A-16A, ISSN: 0735-1097
Ikonomidis I, Andreotti F, Stefanadis C, et al., 1998, Daily life ischaemia in chronic stable angina is related to platelet activation induced by increased cytokine plasma levels, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 394A-394A, ISSN: 0735-1097
Cokkinos P, Kurbaan AS, Nihoyannopoulos P, 1998, Dobutamine stress echocardiography, British Journal of Cardiology, Vol: 5, Pages: 276-285, ISSN: 0969-6113
Pharmacological stress echocardiography is gaining recognition in the UK as a very useful non-invasive technique to evaluate ischaemic heart disease. The two leading categories of pharmacological stress testing are those producing vasodilation, such as adenosine and dipyridamole, and those producing inotropic stimulation, such as dobutamine, arbutamine and isoprenaline. Dobutamine (figure 1) was developed in the 1970s through the chemical modification of isoproterenol.1 The incentive was to treat heart failure with a new inotropic amine which would not produce the sometimes profound changes in heart rate, blood pressure and arrhythmogenic predisposition caused by isoproterenol, noradrenaline and dopamine. The drug had initial clinical use in low-output states such as congestive heart failure post-myocardial infarction, after cardiopulmonary bypass, and dilated cardiomyopathy.2-4 Dobutamine is the pharmacological stressor which has emerged as the best alternative to exercise. It is now widely used together with two-dimensional echocardiography as a diagnostic tool for the investigation of coronary artery disease (CAD) and the evaluation of recoverable myocardial dysfunction following coronary angioplasty or bypass grafting.
Ikonomidis I, Holmes E, Narbuvold H, et al., 1998, Assessment of left ventricular wall motion and delineation of the endocardial border after intravenous injection of Infoson™ during dobutamine stress echocardiography, CORONARY ARTERY DISEASE, Vol: 9, Pages: 567-576, ISSN: 0954-6928
- Author Web Link
- Cite
- Citations: 24
Nihoyannopoulos P, 1998, Value of echo contrast during stress echocardiography, The Thoraxcenter Journal, Vol: 10, Pages: 6-9
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.