Imperial College London
Alternate

ProfessorPetrosNihoyannopoulos

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 3313 8156p.nihoyannopoulos

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rehman:2017:ehjci/jex002,
author = {Rehman, MB and Howard, LS and Christiaens, LP and Gill, D and Gibbs, JSR and Nihoyannopoulos, P},
doi = {ehjci/jex002},
journal = {Eur Heart J Cardiovasc Imaging},
title = {Resting right ventricular function is associated with exercise performance in PAH, but not in CTEPH.},
url = {http://dx.doi.org/10.1093/ehjci/jex002},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims: To assess whether resting right ventricular (RV) function assessed by Global RV longitudinal strain (RVLS) and RV fractional area change (FAC) is associated with exercise performance in pulmonary arterial hypertension (PAH) and in chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results: We prospectively recruited 46 consecutive patients with PAH and 42 patients with CTEPH who were referred for cardio-pulmonary exercise testing (CPET) and transthoracic echocardiography. Resting RV systolic function was assessed with RVLS and FAC. CPET parameters analyzed were percentage of predicted maximal oxygen consumption (VO2max) and the slope of ventilation against carbon dioxide production (VE/VCO2). Spearman correlation was performed between echocardiographic measurements and CPET measurements. In PAH, spearman correlation found an association between RVLS and VE/VCO2 (coefficient = 0.556, P < 0.001) and percentage predicted VO2max (coefficient = -0.393, P = 0.007), while FAC was associated with VE/VCO2 (coefficient = -0.481, P = 0.001) and percentage of predicted VO2max (coefficient = 0.356, P = 0.015). Conversely, in CTEPH, resting RV function was neither associated with percentage of predicted VO2max nor with VE/VCO2, whether assessed by RVLS or FAC. Conclusion: In PAH, resting RV function as assessed by FAC or RVLS is associated with exercise performance and could therefore make a significant contribution to non-invasive assessment in PAH patients. This association is not found in CTEPH, suggesting a disconnection between resting RV function and exercise performance, with implications for the use of exercise measurements as a prognostic marker and clinical/research endpoint in CTEPH.
AU  - Rehman,MB
AU  - Howard,LS
AU  - Christiaens,LP
AU  - Gill,D
AU  - Gibbs,JSR
AU  - Nihoyannopoulos,P
DO  - ehjci/jex002
PY  - 2017///
TI  - Resting right ventricular function is associated with exercise performance in PAH, but not in CTEPH.
T2  - Eur Heart J Cardiovasc Imaging
UR  - http://dx.doi.org/10.1093/ehjci/jex002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28329277
ER  -
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