Imperial College London

ProfessorPeterO'Hare

Faculty of MedicineDepartment of Infectious Disease

Chair in Virology
 
 
 
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Contact

 

+44 (0)20 7594 9517p.ohare Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Summary

We aim to understand the fundamental virus-host interactions underpinning the critical earliest stages in infection by large complex DNA viruses, focusing on herpes simplex virus as a model system. We are particularly interested in two key areas; firstly,  mechanisms of early genome entry and nuclear transport; secondly the competing interactions with the host transcription machinery versus innate immune restriction mechanisms. We are currently pioneering methods combining molecular and cell biology with click-chemistry to study these processes and the single cell and single molecule levels.

Link here to my Research Page:

Publications

Journals

Bodda C, Reinert LS, Fruhwürth S, et al., 2020, HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection, Journal of Experimental Medicine, Vol:217, ISSN:0022-1007

Serwa RA, Sekine E, Brown J, et al., 2019, Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry, Plos Pathogens, Vol:15, ISSN:1553-7366

Ahmad L, Mashbat B, Leung C, et al., 2019, Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection, Journal of Allergy and Clinical Immunology, Vol:143, ISSN:0091-6749, Pages:765-769.e7

Teo CSH, O'Hare P, 2018, A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus, Plos Pathogens, Vol:14, ISSN:1553-7366

Sekine E, Schmidt N, Gaboriau D, et al., 2017, Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy., Plos Pathogens, Vol:13, ISSN:1553-7366

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