Imperial College London

ProfessorPeterO'Hare

Faculty of MedicineDepartment of Medicine

Chair in Virology
 
 
 
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Contact

 

+44 (0)20 7594 9517p.ohare Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Summary

We aim to understand some of the fundamental virus-host interactions underpinning key stages in the herpesvirus life cycle, focusing on herpes simplex virus. We are particularly interested in mechanisms of gene regulation, and in the dissection of  the pathways and components involved in virus entry and exit.  We also exploit virus–host interactions to probe cellular processes in protein trafficking and modification,  secretory transport mechanisms and nuclear organisation.

Link here to my Research Page:

Publications

Journals

Barbosa S, Carreira S, O'Hare P, 2017, GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion, Molecular Biology of the Cell, Vol:28, ISSN:1059-1524, Pages:1565-1579

Teo CSH, Serwa RA, O'Hare P, 2016, Spatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click Chemistry, Plos Pathogens, Vol:12, ISSN:1553-7366

Barbosa S, Carreira S, Bailey D, et al., 2015, Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets., Molecular Biology of the Cell, Vol:26, ISSN:1939-4586, Pages:2939-2954

Hennig T, O'Hare P, 2015, Viruses and the nuclear envelope, Current Opinion in Cell Biology, Vol:34, ISSN:0955-0674, Pages:113-121

Schmidt N, Hennig T, Serwa RA, et al., 2015, Remote activation of host cell DNA synthesis in uninfected cells signalled by infected cells in advance of virus transmission., Journal of Virology, Vol:89, ISSN:1098-5514, Pages:11107-1115

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