We aim to understand some of the fundamental virus-host interactions underpinning key stages in the herpesvirus life cycle, focusing on herpes simplex virus. We are particularly interested in mechanisms of gene regulation, and in the dissection of the pathways and components involved in virus entry and exit. We also exploit virus–host interactions to probe cellular processes in protein trafficking and modification, secretory transport mechanisms and nuclear organisation.
Link here to my Research Page:
Barbosa S, Carreira S, O'Hare P, 2017, GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion, Molecular Biology of the Cell, Vol:28, ISSN:1059-1524, Pages:1565-1579
Teo CSH, Serwa RA, O'Hare P, 2016, Spatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click Chemistry, Plos Pathogens, Vol:12, ISSN:1553-7366
et al., 2015, Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets., Molecular Biology of the Cell, Vol:26, ISSN:1939-4586, Pages:2939-2954
Hennig T, O'Hare P, 2015, Viruses and the nuclear envelope, Current Opinion in Cell Biology, Vol:34, ISSN:0955-0674, Pages:113-121
et al., 2015, Remote activation of host cell DNA synthesis in uninfected cells signalled by infected cells in advance of virus transmission., Journal of Virology, Vol:89, ISSN:1098-5514, Pages:11107-1115