Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Clinical Consul for the Faculty of Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

281 results found

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, MOSAIC Investigators, Moffatt MF, O'Garra A, Openshaw PJMet al., 2019, Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza., Nat Immunol

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article.

JOURNAL ARTICLE

Openshaw P, Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 015: A systemic review and meta-analysis, The Journal of Infectious Diseases

JOURNAL ARTICLE

Openshaw P, Chiu C, Local and systemic immunity against RSV induced by a novel intranasal vaccine (SynGEM), American Journal of Respiratory and Critical Care Medicine, ISSN: 1073-449X

JOURNAL ARTICLE

Helbig C, Williamson C, Fundberg J, Openshaw PJM, Fogdell-Hahn Aet al., 2018, Men and Women in Immunology: Closing the gap on gender parity?, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 48, Pages: 1776-1779, ISSN: 0014-2980

JOURNAL ARTICLE

Thwaites RS, Coates M, Ito K, Ghazaly M, Feather C, Abdulla F, Tunstall T, Jain P, Cass L, Rapeport G, Hansel TT, Nadel S, Openshaw Pet al., 2018, Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 198, Pages: 1074-1084, ISSN: 1073-449X

JOURNAL ARTICLE

Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simoes EAF, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh EE, Stein RT, Graham BS, Bont LJet al., 2018, The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates, LANCET INFECTIOUS DISEASES, Vol: 18, Pages: E295-E311, ISSN: 1473-3099

JOURNAL ARTICLE

Swieboda D, Thwaites R, Nadel S, Hansel T, Openshaw P, Culley Fet al., 2018, The role of innate lymphoid cells in early life lung infection, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Barclay W, Openshaw P, 2018, The 1918 Influenza Pandemic: one hundred years of progress, but where now?, LANCET RESPIRATORY MEDICINE, Vol: 6, Pages: 588-589, ISSN: 2213-2600

JOURNAL ARTICLE

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJMet al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, NATURE IMMUNOLOGY, Vol: 19, Pages: 625-+, ISSN: 1529-2908

JOURNAL ARTICLE

Schwarze J, Openshaw P, Jha A, del Giacco SR, Firinu D, Tsilochristou O, Roberts G, Selby A, Akdis C, Agache I, Custovic A, Heffler E, Pinna G, Khaitov M, Nikonova A, Papadopoulos N, Akhlaq A, Nurmatov U, Renz H, Sheikh A, Skevaki Cet al., 2018, Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force, ALLERGY, Vol: 73, Pages: 1151-1181, ISSN: 0105-4538

JOURNAL ARTICLE

Thwaites RS, Gunawardana NC, Broich V, Mann EH, Ahnstrom J, Campbell GA, Lindsley S, Singh N, Tunstall T, Lane DA, Openshaw PJ, Hawrylowicz CM, Hansel TTet al., 2018, Biphasic activation of complement and fibrinolysis during the human nasal allergic response, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 141, Pages: 1892-+, ISSN: 0091-6749

JOURNAL ARTICLE

Tripp RA, Power UF, Openshaw PJM, Kauvar LMet al., 2018, Respiratory Syncytial Virus: Targeting the G Protein Provides a New Approach for an Old Problem, JOURNAL OF VIROLOGY, Vol: 92, ISSN: 0022-538X

JOURNAL ARTICLE

Petrarca L, Midulla F, Openshaw PJM, 2018, Vaccination policies in Europe: Common goals, diverse approaches and public doubts, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 48, Pages: 10-12, ISSN: 0014-2980

JOURNAL ARTICLE

Jha A, Thwaites RS, Tunstall T, Kon OM, Shattock RJ, Openshaw PJ, Hansel TTet al., 2018, Human Nasal Challenge with TLR7/8 Agonist Resiquimod (R848) Induces Mucosal Interferon-alpha, with Increased Responsiveness in Asthmatic Volunteers, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Thwaites RS, Jarvis HC, Singh N, Jha A, Pritchard A, Fan H, Tunstall T, Nanan J, Nadel S, Kon OM, Openshaw PJ, Hansel TTet al., 2018, Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X

JOURNAL ARTICLE

Sheerin D, Openshaw PJM, Pollard AJ, 2017, Issues in vaccinology: Present challenges and future directions, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 47, Pages: 2017-2025, ISSN: 0014-2980

JOURNAL ARTICLE

Vlachantoni I, Ascough S, Grimaldi R, Leenhouts K, Chiu C, Openshaw Pet al., 2017, PHASE 1 TRIAL OF AN INTRANASAL RESPIRATORY SYNCYTIAL VIRUS (RSV) SUBUNIT CANDIDATE VACCINE: SAFETY RESULTS FROM THE MUC-SYNGEM STUDY, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A43-A44, ISSN: 0040-6376

CONFERENCE PAPER

Jha A, Jarvis H, Fraser C, Openshaw PJMet al., 2017, Respiratory Syncytial Virus

Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million cases in children younger than 5 years, with 10% requiring hospital admission and up to 199,000 dying of the disease. There is growing evidence that severe infantile RSV bronchiolitis, a condition characterised by an inflammatory reaction to the virus, is associated with later childhood wheeze in some vulnerable children; however, a direct causal relationship with asthma has not yet been established. It is also increasingly recognised as a cause of morbidity and mortality in those with underlying airway disease, immunocompromise and frail elderly persons. Novel molecular based diagnostic tools are becoming established but treatment largely remains supportive, with palivizumab being the only licensed agent currently available for passive prophylaxis of selected pre-term infants. Whilst effective treatments remain elusive, there is optimism about the testing of novel antiviral drugs and the development of vaccines that may induce long-lasting immunity without the risk of disease augmentation.

BOOK CHAPTER

Heath PT, Culley FJ, Jones CE, Kampmann B, Le Doare K, Nunes MC, Sadarangani M, Chaudhry Z, Baker CJ, Openshaw PJMet al., 2017, Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis, LANCET INFECTIOUS DISEASES, Vol: 17, Pages: E223-E234, ISSN: 1473-3099

JOURNAL ARTICLE

Marchant A, Sadarangani M, Garand M, Dauby N, Verhasselt V, Pereira L, Bjornson G, Jones CE, Halperin SA, Edwards KM, Heath P, Openshaw PJ, Scheifele DW, Kollmann TRet al., 2017, Maternal immunisation: collaborating with mother nature, LANCET INFECTIOUS DISEASES, Vol: 17, Pages: E197-E208, ISSN: 1473-3099

JOURNAL ARTICLE

Thwaites RS, Ito K, Chingono JMS, Coates M, Jarvis HC, Tunstall T, Anderson-Dring L, Cass L, Rapeport G, Openshaw PJ, Nadel S, Hansel TTet al., 2017, Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 1240-1244, ISSN: 0022-1899

JOURNAL ARTICLE

Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho L-Pet al., 2017, M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza, JCI INSIGHT, Vol: 2, ISSN: 2379-3708

JOURNAL ARTICLE

Fraser CS, Jha A, Openshaw PJM, 2017, Vaccines in the Prevention of Viral Pneumonia, CLINICS IN CHEST MEDICINE, Vol: 38, Pages: 155-+, ISSN: 0272-5231

JOURNAL ARTICLE

Openshaw PJM, 2017, RSV Takes Control of Neonatal Breg Cells: Two Hands on the Wheel, IMMUNITY, Vol: 46, Pages: 171-173, ISSN: 1074-7613

JOURNAL ARTICLE

Thwaites RS, Gunawardana NC, Broich VL, Mann EH, Campbell GA, Tunstall T, Lindsley S, Hawrylowicz CM, Openshaw PJM, Hansel TTet al., 2017, Activation of the Complement, Coagulation and Fibrinolysis Pathways after Nasal Allergen Challenge, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB384-AB384, ISSN: 0091-6749

CONFERENCE PAPER

Openshaw PJM, Chiu C, Culley FJ, Johansson Cet al., 2017, Protective and Harmful Immunity to RSV Infection, ANNUAL REVIEW OF IMMUNOLOGY, VOL 35, Vol: 35, Pages: 501-532, ISSN: 0732-0582

JOURNAL ARTICLE

Gunawardana N, Campbell G, Lindsley S, Thwaites R, Mann E, Tunstall T, Openshaw P, Johnston S, Hawrylowicz C, Hansel Tet al., 2016, The effect of vitamin D supplementation on cathelicidin levels, vitamin D receptor (VDR) and E-cadherin expression after nasal allergen challenge in allergic rhinitis, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1666-1666, ISSN: 0954-7894

CONFERENCE PAPER

Openshaw P, 2016, Brexit: A view from the BSI, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 46, Pages: 2065-2067, ISSN: 0014-2980

JOURNAL ARTICLE

Jha A, Dunning J, Tunstall T, Hansel T, Openshaw Pet al., 2016, Asthma patients hospitalized with influenza lack mucosal and systemic type 2 inflammation, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Mazein A, De Meulder B, Lefaudeux D, Knowles RG, Wheelock C, Dahlen S-E, Chung F, Adcock I, Openshaw P, Roberts G, Djukanovic R, Gawron P, Ostaszewski M, Toure V, Kuzma M, Saqi M, Pellet J, Schneider R, Balling R, Sterk P, Auffray Cet al., 2016, LSC Abstract - The AsthmaMap: Towards a community-driven reconstruction of asthma-relevant pathways and networks, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

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