Publications
449 results found
Openshaw PJ, 2001, Potential mechanisms causing delayed effects of respiratory syncytial virus infection., Am J Respir Crit Care Med, Vol: 163, Pages: S10-S13, ISSN: 1073-449X
Johnston SL, Openshaw PJM, 2001, The protective effect of childhood infections - The next challenge is to mimic safely this protection against allergy and asthma, BRITISH MEDICAL JOURNAL, Vol: 322, Pages: 376-377, ISSN: 0959-8138
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- Citations: 16
Simmons CP, Hussell T, Sparer T, et al., 2001, Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8<SUP>+</SUP> T cell responses, JOURNAL OF IMMUNOLOGY, Vol: 166, Pages: 1106-1113, ISSN: 0022-1767
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- Citations: 84
Hussell T, Openshaw PJM, 2000, IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions, JOURNAL OF IMMUNOLOGY, Vol: 165, Pages: 7109-7115, ISSN: 0022-1767
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- Citations: 54
Pennycook A, Openshaw P, Hussell T, 2000, Partners in crime: co-infections in the developing world, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 122, Pages: 296-299, ISSN: 0009-9104
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- Citations: 8
Walzl G, Tafuro S, Moss P, et al., 2000, Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 192, Pages: 1317-1326, ISSN: 0022-1007
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- Citations: 104
Godkin AJ, Thursz M, Openshaw P, et al., 2000, Identification of HLA-DR11-restricted CD4+T cell epitopes derived from hepatitis C virus., HEPATOLOGY, Vol: 32, Pages: 271A-271A, ISSN: 0270-9139
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- Citations: 1
Pala P, Hussell T, Openshaw PJM, 2000, Flow cytometric measurement of intracellular cytokines, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 243, Pages: 107-124, ISSN: 0022-1759
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- Citations: 170
Openshaw PJM, Hewitt C, 2000, Protective and harmful effects of viral infections in childhood on wheezing disorders and asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 162, Pages: S40-S43, ISSN: 1073-449X
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- Citations: 25
Pala A, Verhoef A, Lamb JR, et al., 2000, Single cell analysis of cytokine expression kinetics by human CD4<SUP>+</SUP> T-cell clones during activation or tolerance induction, IMMUNOLOGY, Vol: 100, Pages: 209-216, ISSN: 0019-2805
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- Citations: 11
Folkerts G, Walzl G, Openshaw P, 2000, Clean living increases more than just atopic disease - Reply, IMMUNOLOGY TODAY, Vol: 21, Pages: 249-250, ISSN: 0167-5699
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- Citations: 51
Folkerts G, Walzl G, Openshaw PJ, 2000, Do common childhood infections 'teach' the immune system not to be allergic?, Immunol Today, Vol: 21, Pages: 118-120, ISSN: 0167-5699
Smyth RL, Fletcher JN, Thomas HM, et al., 1999, Respiratory syncytial virus and wheeze, LANCET, Vol: 354, Pages: 1997-1998, ISSN: 0140-6736
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- Citations: 17
Openshaw PJM, Walzl G, 1999, Infections prevent the development of asthma - true, false or both?, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 92, Pages: 495-499, ISSN: 0141-0768
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- Citations: 14
Hussell T, Openshaw P, 1999, Recent developments in the biology of respiratory syncytial virus: are vaccines and new treatments just round the corner?, CURRENT OPINION IN MICROBIOLOGY, Vol: 2, Pages: 410-414, ISSN: 1369-5274
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- Citations: 13
Marshall BG, Hussell T, Matthews S, et al., 1999, Immune deviation by BCG in a susceptible murine model of <i>Cryptococcus</i> <i>neoformans</i> infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A869-A869, ISSN: 1073-449X
Hussell T, Georgiou A, Sparer TE, et al., 1998, Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection, JOURNAL OF IMMUNOLOGY, Vol: 161, Pages: 6215-6222, ISSN: 0022-1767
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- Citations: 87
O'Donnell DR, Openshaw PJM, 1998, Anaphylactic sensitization to aeroantigen during respiratory virus infection, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 28, Pages: 1501-1508, ISSN: 0954-7894
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- Citations: 56
Hussell T, Openshaw PJM, 1998, Intracellular IFN-γ expression in natural killer cells precedes lung CD8<SUP>+</SUP> T cell recruitment during respiratory syncytial virus infection, JOURNAL OF GENERAL VIROLOGY, Vol: 79, Pages: 2593-2601, ISSN: 0022-1317
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- Citations: 135
O'Donnell DR, McGarvey MJ, Tully JM, et al., 1998, Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection, JOURNAL OF PEDIATRICS, Vol: 133, Pages: 272-274, ISSN: 0022-3476
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- Citations: 45
Openshaw PJ, Lemanske RF, 1998, Respiratory viruses and asthma: can the effects be prevented?, Eur Respir J Suppl, Vol: 27, Pages: 35s-39s, ISSN: 0904-1850
Although viral respiratory tract infections (RTIs) frequently cause exacerbations of asthma, the relationship between RTIs and the initiation and maintenance of asthma in childhood is unclear. This is in part because of the difficulty of defining asthma in young children. Current evidence supports two hypotheses: 1) that predisposed children are susceptible to both severe RTIs and asthma; and 2) that severe viral infections may have long-lasting influences on the subsequent development of asthma, and perhaps even atopy. These two proposals are not mutually exclusive. This review summarizes our current state of knowledge of the pathogenic interactions between viruses and asthma (in both human and animal models). Possible interventions that might modify the effects of viral disease in asthmatics are discussed.
Spender LC, Hussell T, Openshaw PJM, 1998, Abundant IFN-γ production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease, JOURNAL OF GENERAL VIROLOGY, Vol: 79, Pages: 1751-1758, ISSN: 0022-1317
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- Citations: 39
Openshaw PJ, Lemanske RF, 1998, Respiratory viruses and asthma: can the effects be prevented?, Workshop on Early Intervention in Childhood Asthma, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, Pages: 35S-39S, ISSN: 0903-1936
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- Citations: 7
Sparer TE, Matthews S, Hussell T, et al., 1998, Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 187, Pages: 1921-1926, ISSN: 0022-1007
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- Citations: 116
Openshaw PJ, Hussell T, 1998, The effect of IL-12 treatment on vaccine-enhanced illness during infection with respiratory syncytial virus, MODULATION OF THE IMMUNE RESPONSE TO VACCINE ANTIGENS, Vol: 92, Pages: 179-185, ISSN: 0301-5149
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- Citations: 9
Hillery E, Hussell T, Cheng S, et al., 1997, Effects of influenza virus on gene transfer in vivo, Thorax, Vol: 52, ISSN: 0040-6376
The level of gene expression following DNA transfer is currently suboptimal. Key barriers contributing to this inefficiency include the apical plasma membrane, and entrappment of the plasmid DNA in the endosomal pathway. Gene transfer need not only occur via the apical membrane of the epithelium, the basolateral surface representing an alternative route. However, tight junctions present beteen the cells of the epithelium are likely to impede access to this membrane. It is well recognised that infection with the influenza virus leads to epithelial inflammation (and hence increased permeability) as well as endosomal lysis. We have therefore assessed whether either of these processes may increase gene transfer efficiency. Plasmid DNA encoding the gene for chloramphenicol acetyl transferase (CAT), driven by a CMV promoter, was complexed to cationic liposomes containing lipid #67, and administered to the lungs of eight-week old female BalbC mice by nasal application. As it has previously been shown that maximum epithelial inflammation without epithelial shedding occurs 4 days after infection with this virus, mice in cohort 1 were given 50 μl of 10-4 HA of inflenza virus (strain x31 HA4096) on day 0 followed by a single dose of 80 μg of complexed plasmid on day 4. Mice in cohort 2 were given 50 μl of 10-4 HA of influenza virus, followed immediately by 80 μg of complexed plasmid. Mice in the positive control group (cohort 3) received 80 μg of complexed plasmid alone. All animals were sacrificed 24 hours following administration of the plasmid DNA, and the lung homogenates assayed for CAT activity. The highest levels of CAT expression were seen in cohort 3 (10.5 × 10-6 ± 2.9 CAT U/μg protein. In cohort 2, where the influenza virus and the plasmid DNA had been instilled together, expression levels were 4.3 × 10-6 ± 1.0 CAT U/μg protein. In cohort 1 expression levels were 0.06 × 10-6 ± 0.06 CAT U/μg protein. We co
Hussell T, Baldwin CJ, O'Garra A, et al., 1997, CD8<SUP>+</SUP> T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 27, Pages: 3341-3349, ISSN: 0014-2980
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- Citations: 195
Hussell T, Khan U, Openshaw P, 1997, IL-12 treatment attenuates T helper cell type 2 and B cell responses but does not improve vaccine-enhanced lung illness, JOURNAL OF IMMUNOLOGY, Vol: 159, Pages: 328-334, ISSN: 0022-1767
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- Citations: 57
Openshaw P, Khan U, Hussell T, 1997, IL-12 induces Th1 responses but does not prevent vaccine-enhanced illness during viral challenge., JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 99, Pages: 1496-1496, ISSN: 0091-6749
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