Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Openshaw:2020:infdis/jiz059,
author = {Openshaw, P},
doi = {infdis/jiz059},
journal = {Journal of Infectious Diseases},
pages = {S577--S583},
title = {Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 015: a systemic review and meta-analysis},
url = {http://dx.doi.org/10.1093/infdis/jiz059},
volume = {222},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory syncytial virus associated acute respiratory infection (RSV-ARI)constitutes a substantial disease burden in older adults≥65 years. We aimed to identify all studies worldwide investigating the disease burden ofRSV-ARIin this population. We estimated thecommunityincidence, hospitalisationrate and in-hospital case fatality ratio (hCFR) of  RSV-ARI in  older  adults  stratified  by industrialized anddeveloping regions,  with  data  from a systematic review ofstudies published between January 1996 and April 2018, and from 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015, to calculate the global and regional burdenin older adults with RSV-ARIin community and in hospital duringthat year. We  estimated  thenumber  ofin-hospital RSV-ARIdeaths  by  combining hCFR with  hospital admission estimates from hospital-based studies. In  2015, there  were  about 1.5million(95%  CI  0.3-6.9) episodes  of RSV-ARIin  older  adults in41industrialised countries (data missing in developing countries), and of these 214,000 (~14.5%; 95% CI 100,000-459,000) were admitted to hospitals. The global number of hospital admissionsforRSV-ARI in  older adults was  estimated at 336,000 (UR  186,000-614,000).We  further  estimated  about  14,000 (UR  5,000-50,000) in-hospital  deaths  related  to  RSV-ARIglobally.The  hospital  admission rate and hCFR were higher for those ≥65 years than those aged 50-64 years. The disease burden of RSV-ARIamong older adults is substantialwith limited data from developing countries; appropriate prevention and management strategiesare needed to reduce this burden.
AU  - Openshaw,P
DO  - infdis/jiz059
EP  - 583
PY  - 2020///
SN  - 0022-1899
SP  - 577
TI  - Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 015: a systemic review and meta-analysis
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiz059
UR  - http://hdl.handle.net/10044/1/67274
VL  - 222
ER  -
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