Publications

BibTex format

@article{Peng:2020:10.1038/s41590-020-0782-6,
author = {Peng, Y and Mentzer, AJ and Liu, G and Yao, X and Yin, Z and Dong, D and Dejnirattisai, W and Rostron, T and Supasa, P and Liu, C and López-Camacho, C and Slon-Campos, J and Zhao, Y and Stuart, DI and Paesen, GC and Grimes, JM and Antson, AA and Bayfield, OW and Hawkins, DEDP and Ker, D and Wang, B and Turtle, L and Subramaniam, K and Thomson, P and Zhang, P and Dold, C and Ratcliff, J and Simmonds, P and de, Silva T and Sopp, P and Wellington, D and Rajapaksa, U and Chen, Y and Salio, M and Napolitani, G and Paes, W and Borrow, P and Kessler, BM and Fry, JW and Schwabe, NF and Semple, MG and Baillie, JK and Moore, SC and Openshaw, PJM and Ansari, MA and Dunachie, S and Barnes, E and Frater, J and Kerr, G and Goulder, P and Lockett, T and Levin, R and Zhang, Y and Jing, R and Ho, L and Barnes, E and Dong, D and Dong, T and Dunachie, S and Frater, J and Goulder, P and Kerr, G and Klenerman, P and Liu, G and McMichael, A and Napolitani, G and Ogg, G and Peng, Y and Salio, M and Yao, X an},
doi = {10.1038/s41590-020-0782-6},
journal = {Nature Immunology},
title = {Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19},
url = {http://dx.doi.org/10.1038/s41590-020-0782-6},
year = {2020}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide–MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
AU  - Peng,Y
AU  - Mentzer,AJ
AU  - Liu,G
AU  - Yao,X
AU  - Yin,Z
AU  - Dong,D
AU  - Dejnirattisai,W
AU  - Rostron,T
AU  - Supasa,P
AU  - Liu,C
AU  - López-Camacho,C
AU  - Slon-Campos,J
AU  - Zhao,Y
AU  - Stuart,DI
AU  - Paesen,GC
AU  - Grimes,JM
AU  - Antson,AA
AU  - Bayfield,OW
AU  - Hawkins,DEDP
AU  - Ker,D
AU  - Wang,B
AU  - Turtle,L
AU  - Subramaniam,K
AU  - Thomson,P
AU  - Zhang,P
AU  - Dold,C
AU  - Ratcliff,J
AU  - Simmonds,P
AU  - de,Silva T
AU  - Sopp,P
AU  - Wellington,D
AU  - Rajapaksa,U
AU  - Chen,Y
AU  - Salio,M
AU  - Napolitani,G
AU  - Paes,W
AU  - Borrow,P
AU  - Kessler,BM
AU  - Fry,JW
AU  - Schwabe,NF
AU  - Semple,MG
AU  - Baillie,JK
AU  - Moore,SC
AU  - Openshaw,PJM
AU  - Ansari,MA
AU  - Dunachie,S
AU  - Barnes,E
AU  - Frater,J
AU  - Kerr,G
AU  - Goulder,P
AU  - Lockett,T
AU  - Levin,R
AU  - Zhang,Y
AU  - Jing,R
AU  - Ho,L
AU  - Barnes,E
AU  - Dong,D
AU  - Dong,T
AU  - Dunachie,S
AU  - Frater,J
AU  - Goulder,P
AU  - Kerr,G
AU  - Klenerman,P
AU  - Liu,G
AU  - McMichael,A
AU  - Napolitani,G
AU  - Ogg,G
AU  - Peng,Y
AU  - Salio,M
AU  - Yao,X
AU  - Yin,Z
AU  - Kenneth,Baillie J
AU  - Klenerman,P
AU  - Mentzer,AJ
AU  - Moore,SC
AU  - Openshaw,PJM
AU  - Semple,MG
AU  - Stuart,DI
AU  - Turtle,L
AU  - Cornall,RJ
AU  - Conlon,CP
AU  - Klenerman,P
AU  - Screaton,GR
AU  - Mongkolsapaya,J
AU  - McMichael,A
AU  - Knight,JC
AU  - Ogg,G
AU  - Dong,T
AU  - Oxford,Immunology Network Covid-19 Response T cell Consortium
AU  - ISARIC4C,Investigators
DO  - 10.1038/s41590-020-0782-6
PY  - 2020///
SN  - 1529-2916
TI  - Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
T2  - Nature Immunology
UR  - http://dx.doi.org/10.1038/s41590-020-0782-6
UR  - https://doi.org/10.1038/s41590-020-0782-6
ER  -

Download

Peter Openshaw - Professor of Experimental Medicine

Contact

Assistant

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)