Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jacobsen:2021:10.1038/s41467-021-25220-3,
author = {Jacobsen, H and Walendy-Gnirss, K and Tekin-Bubenheim, N and Kouassi, NM and Ben-Batalla, I and Berenbrok, N and Wolff, M and dos, Reis VP and Zickler, M and Scholl, L and Gries, A and Jania, H and Kloetgen, A and Duesedau, A and Pilnitz-Stolze, G and Jeridi, A and Yildirim, AO and Fuchs, H and Gailus-Durner, V and Stoeger, C and de, Angelis MH and Manuylova, T and Klingel, K and Culley, FJ and Behrends, J and Loges, S and Schneider, B and Krauss-Etschmann, S and Openshaw, P and Gabriel, G},
doi = {10.1038/s41467-021-25220-3},
journal = {Nature Communications},
title = {Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life},
url = {http://dx.doi.org/10.1038/s41467-021-25220-3},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.
AU  - Jacobsen,H
AU  - Walendy-Gnirss,K
AU  - Tekin-Bubenheim,N
AU  - Kouassi,NM
AU  - Ben-Batalla,I
AU  - Berenbrok,N
AU  - Wolff,M
AU  - dos,Reis VP
AU  - Zickler,M
AU  - Scholl,L
AU  - Gries,A
AU  - Jania,H
AU  - Kloetgen,A
AU  - Duesedau,A
AU  - Pilnitz-Stolze,G
AU  - Jeridi,A
AU  - Yildirim,AO
AU  - Fuchs,H
AU  - Gailus-Durner,V
AU  - Stoeger,C
AU  - de,Angelis MH
AU  - Manuylova,T
AU  - Klingel,K
AU  - Culley,FJ
AU  - Behrends,J
AU  - Loges,S
AU  - Schneider,B
AU  - Krauss-Etschmann,S
AU  - Openshaw,P
AU  - Gabriel,G
DO  - 10.1038/s41467-021-25220-3
PY  - 2021///
SN  - 2041-1723
TI  - Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-25220-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000686641700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-021-25220-3
UR  - http://hdl.handle.net/10044/1/95839
VL  - 12
ER  -
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