Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lin:2021:10.1038/s41467-021-25265-4,
author = {Lin, G-L and Drysdale, SB and Snape, MD and O'Connor, D and Brown, A and Maclntyre-Cockett, G and Mellado-Gomez, E and de, Cesare M and Bonsall, D and Ansari, MA and Oner, D and Aerssens, J and Butler, C and Bont, L and Openshaw, P and Martinon-Torres, F and Nair, H and Bowden, R and Golubchik, T and Pollard, AJ},
doi = {10.1038/s41467-021-25265-4},
journal = {Nature Communications},
pages = {1--11},
title = {Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus},
url = {http://dx.doi.org/10.1038/s41467-021-25265-4},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017–2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.
AU  - Lin,G-L
AU  - Drysdale,SB
AU  - Snape,MD
AU  - O'Connor,D
AU  - Brown,A
AU  - Maclntyre-Cockett,G
AU  - Mellado-Gomez,E
AU  - de,Cesare M
AU  - Bonsall,D
AU  - Ansari,MA
AU  - Oner,D
AU  - Aerssens,J
AU  - Butler,C
AU  - Bont,L
AU  - Openshaw,P
AU  - Martinon-Torres,F
AU  - Nair,H
AU  - Bowden,R
AU  - Golubchik,T
AU  - Pollard,AJ
DO  - 10.1038/s41467-021-25265-4
EP  - 11
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-25265-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000691126200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-021-25265-4
UR  - http://hdl.handle.net/10044/1/92026
VL  - 12
ER  -
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