Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{McGinley:2022:infdis/jiab370,
author = {McGinley, J and Thwaites, R and Brebner, W and Greenan-Barrett, L and Aerssens, J and Öner, D and Bont, L and Wildenbeest, J and Martinón-Torres, F and Nair, H and Pollard, AJ and Openshaw, P and Drysdale, S and REspiratory, Syncytial virus Consortium in EUrope RESCEU Investigators},
doi = {infdis/jiab370},
journal = {Journal of Infectious Diseases},
pages = {S117--S129},
title = {A systematic review and meta-analysis of animal studies investigating the relationship between serum antibody, T lymphocytes, and respiratory syncytial virus disease},
url = {http://dx.doi.org/10.1093/infdis/jiab370},
volume = {226},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Respiratory syncytial virus (RSV) infections occur in human populations around the globe, causing disease of variable severity, disproportionately affecting infants and older adults (>65 years of age). Immune responses can be protective but also contribute to disease. Experimental studies in animals enable detailed investigation of immune responses, provide insights into clinical questions, and accelerate the development of passive and active vaccination. We aimed to review the role of antibody and T-cell responses in relation to RSV disease severity in animals. METHODS: Systematic review and meta-analysis of animal studies examining the association between T-cell responses/phenotype or antibody titers and severity of RSV disease. The PubMed, Zoological Record, and Embase databases were screened from January 1980 to May 2018 to identify animal studies of RSV infection that assessed serum antibody titer or T lymphocytes with disease severity as an outcome. Sixty-three studies were included in the final review. RESULTS: RSV-specific antibody appears to protect from disease in mice, but such an effect was less evident in bovine RSV. Strong T-cell, Th1, Th2, Th17, CD4/CD8 responses, and weak Treg responses accompany severe disease in mice. CONCLUSIONS: Murine studies suggest that measures of T-lymphocyte activity (particularly CD4 and CD8 T cells) may be predictive biomarkers of severity. Further inquiry is merited to validate these results and assess relevance as biomarkers for human disease.
AU  - McGinley,J
AU  - Thwaites,R
AU  - Brebner,W
AU  - Greenan-Barrett,L
AU  - Aerssens,J
AU  - Öner,D
AU  - Bont,L
AU  - Wildenbeest,J
AU  - Martinón-Torres,F
AU  - Nair,H
AU  - Pollard,AJ
AU  - Openshaw,P
AU  - Drysdale,S
AU  - REspiratory,Syncytial virus Consortium in EUrope RESCEU Investigators
DO  - infdis/jiab370
EP  - 129
PY  - 2022///
SN  - 0022-1899
SP  - 117
TI  - A systematic review and meta-analysis of animal studies investigating the relationship between serum antibody, T lymphocytes, and respiratory syncytial virus disease
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiab370
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34522970
UR  - https://academic.oup.com/jid/article/226/Supplement_1/S117/6370415
UR  - http://hdl.handle.net/10044/1/92022
VL  - 226
ER  -
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