Imperial College London
Portrait Picture

Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
//

Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
//

Location

 

353Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cole:2017:10.1172/jci.insight.91868,
author = {Cole, SL and Dunning, J and Kok, WL and Benam, KH and Benlahrech, A and Repapi, E and Martinez, FO and Drumright, L and Powell, TJ and Bennett, M and Elderfield, R and Thomas, C and MOSAIC, investigators and Dong, T and McCauley, J and Liew, FY and Taylor, S and Zambon, M and Barclay, W and Cerundolo, V and Openshaw, PJ and McMichael, AJ and Ho, LP},
doi = {10.1172/jci.insight.91868},
journal = {JCI Insight},
title = {M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.},
url = {http://dx.doi.org/10.1172/jci.insight.91868},
volume = {2},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one specific influenza A strain. This analysis was compared with similarly hospitalized influenza patients with known risk factors (total of n = 60 patients recruited). We found a sustained increase in a specific subset of proinflammatory monocytes, with high TNF-α expression and an M1-like phenotype (independent of viral titers), in these previously healthy patients with severe disease. The relationship between M1-like monocytes and immunopathology was strengthened using murine models of influenza, in which severe infection generated using different models (including the high-pathogenicity H5N1 strain) was also accompanied by high levels of circulating M1-like monocytes. Additionally, a raised M1/M2 macrophage ratio in the lungs was observed. These studies identify a specific subtype of monocytes as a modifiable immunological determinant of disease severity in this subgroup of severely ill, previously healthy patients, offering potential novel therapeutic avenues.
AU  - Cole,SL
AU  - Dunning,J
AU  - Kok,WL
AU  - Benam,KH
AU  - Benlahrech,A
AU  - Repapi,E
AU  - Martinez,FO
AU  - Drumright,L
AU  - Powell,TJ
AU  - Bennett,M
AU  - Elderfield,R
AU  - Thomas,C
AU  - MOSAIC,investigators
AU  - Dong,T
AU  - McCauley,J
AU  - Liew,FY
AU  - Taylor,S
AU  - Zambon,M
AU  - Barclay,W
AU  - Cerundolo,V
AU  - Openshaw,PJ
AU  - McMichael,AJ
AU  - Ho,LP
DO  - 10.1172/jci.insight.91868
PY  - 2017///
SN  - 2379-3708
TI  - M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.
T2  - JCI Insight
UR  - http://dx.doi.org/10.1172/jci.insight.91868
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28405622
UR  - http://hdl.handle.net/10044/1/48142
VL  - 2
ER  -
Download