Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Heath:2017:10.1016/S1473-3099(17)30232-3,
author = {Heath, PT and Culley, FJ and Jones, CE and Kampmann, B and Le, Doare K and Nunes, MC and Sadarangani, M and Chaudhry, Z and Baker, CJ and Openshaw, PJM},
doi = {10.1016/S1473-3099(17)30232-3},
journal = {Lancet Infectious Diseases},
pages = {e223--e234},
title = {Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis},
url = {http://dx.doi.org/10.1016/S1473-3099(17)30232-3},
volume = {17},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Group B streptococcus and respiratory syncytial virus are leading causes of infant morbidity and mortality worldwide. No licensed vaccines are available for either disease, but vaccines for both are under development. Severe respiratory syncytial virus disease can be prevented by passively administered antibody. The presence of maternal IgG antibody specific to respiratory syncytial virus is associated with reduced prevalence and severity of respiratory syncytial virus disease in the first few weeks of life, whereas maternal serotype-specific anticapsular antibody is associated with protection against both early-onset and late-onset group B streptococcus disease. Therefore, vaccination in pregnancy might protect infants against both diseases. This report describes what is known about immune protection against group B streptococcus and respiratory syncytial virus, identifies knowledge gaps regarding the immunobiology of both diseases, and aims to prioritise research directions in maternal immunisation.
AU  - Heath,PT
AU  - Culley,FJ
AU  - Jones,CE
AU  - Kampmann,B
AU  - Le,Doare K
AU  - Nunes,MC
AU  - Sadarangani,M
AU  - Chaudhry,Z
AU  - Baker,CJ
AU  - Openshaw,PJM
DO  - 10.1016/S1473-3099(17)30232-3
EP  - 234
PY  - 2017///
SN  - 1473-3099
SP  - 223
TI  - Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(17)30232-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403825500003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49897
VL  - 17
ER  -
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