Imperial College London
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Peter Openshaw - Professor of Experimental Medicine

Faculty of Medicine, National Heart & Lung Institute

Proconsul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tripp:2017:10.1128/JVI.01302-17,
author = {Tripp, RA and Power, UF and Openshaw, PJM and Kauvar, LM},
doi = {10.1128/JVI.01302-17},
journal = {Journal of Virology},
title = {Respiratory Syncytial Virus (RSV): Targeting the G Protein Provides a New Approach for an Old Problem.},
url = {http://dx.doi.org/10.1128/JVI.01302-17},
volume = {92},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) annually affecting >2 million children in the US <5 years old. In the elderly (>65 years old), RSV results in ∼175,000 hospitalizations annually in the US with worldwide incidence ∼34 million. There is no approved RSV vaccine and treatments are limited. Recently, a Phase 3 trial in the elderly using a recombinant RSV F protein vaccine failed to meet its efficacy objectives, namely prevention of moderate-to-severe RSV-associated LRTI and reduced incidence of acute respiratory disease. Moreover, a recent Phase 3 trial evaluating suptavumab (REGN2222), an antibody to RSV F protein, did not meet its primary endpoint of preventing medically attended RSV infections in pre-term infants. Despite these setbacks, numerous efforts targeting the RSV F protein with vaccines, antibodies, and small molecules continue based on the commercial success of a monoclonal antibody (mAb) against the RSV F protein (palivizumab). As the understanding of RSV biology has improved, the other major coat protein, the RSV G protein, has re-emerged as an alternative target reflecting progress in understanding its roles in infecting bronchial epithelial cells and in altering the host immune response. In mouse models, a high-affinity, strain-independent human mAb to the RSV G protein has shown potent direct antiviral activity combined with the alleviation of virus-induced immune system effects that contribute to disease pathology. This mAb, being prepared for clinical trials, provides a qualitatively new approach to managing RSV for populations not eligible for prophylaxis with palivizumab.
AU  - Tripp,RA
AU  - Power,UF
AU  - Openshaw,PJM
AU  - Kauvar,LM
DO  - 10.1128/JVI.01302-17
PY  - 2017///
SN  - 1098-5514
TI  - Respiratory Syncytial Virus (RSV): Targeting the G Protein Provides a New Approach for an Old Problem.
T2  - Journal of Virology
UR  - http://dx.doi.org/10.1128/JVI.01302-17
UR  - http://hdl.handle.net/10044/1/56406
VL  - 92
ER  -
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