Imperial College London

ProfessorPaoloVineis

Faculty of MedicineSchool of Public Health

Chair in Environmental Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
//

Location

 

511Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Publication Type
Year
to

801 results found

Ambatipudi S, Horvath S, Perrier F, Cuenin C, Hernandez-Vargas H, Le Calvez-Kelm F, Durand G, Byrnes G, Ferrari P, Bouaoun L, Sklias A, Chajes V, Overvad K, Seven G, Baglietto L, Clavel-Chapelon F, Kaaks R, Barrdahl M, Boeing H, Trichopoulou A, Lagiou P, Naska A, Masala G, Agnoli C, Polidoro S, Tumino R, Panico S, Dolle M, Peeters PHM, Onland-Moret NC, Sandanger TM, Nost TH, Weiderpass E, Quiros JR, Agudo A, Rodriguez-Barranco M, Castano JMH, Barricarte A, Fernandez AM, Travis RC, Vineis P, Muller DC, Riboli E, Gunter M, Romieu I, Herceg Zet al., 2017, DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility, EUROPEAN JOURNAL OF CANCER, Vol: 75, Pages: 299-307, ISSN: 0959-8049

JOURNAL ARTICLE

Baglietto L, Ponzi E, Haycock P, Hodge A, Assumma MB, Jung C-H, Chung J, Fasanelli F, Guida F, Campanella G, Chadeau-Hyam M, Grankvist K, Johansson M, Ala U, Provero P, Wong EM, Joo J, English DR, Kazmi N, Lund E, Faltus C, Kaaks R, Risch A, Barrdahl M, Sandanger TM, Southey MC, Giles GG, Johansson M, Vineis P, Polidoro S, Relton CL, Severi Get al., 2017, DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 50-61, ISSN: 0020-7136

JOURNAL ARTICLE

Barrera-Gomez J, Agier L, Portengen L, Chadeau-Hyam M, Giorgis-Allemand L, Siroux V, Robinson O, Vlaanderen J, Gonzalez JR, Nieuwenhuijsen M, Vineis P, Vrijheid M, Vermeulen R, Slama R, Basagana Xet al., 2017, A systematic comparison of statistical methods to detect interactions in exposome-health associations, ENVIRONMENTAL HEALTH, Vol: 16, ISSN: 1476-069X

JOURNAL ARTICLE

Boccardi M, Gallo V, Yasui Y, Vineis P, Padovani A, Mosimann U, Giannakopoulos P, Gold G, Dubois B, Jack CR, Winblad B, Frisoni GB, Albanese Eet al., 2017, The biomarker-based diagnosis of Alzheimer's disease. 2-lessons from oncology, NEUROBIOLOGY OF AGING, Vol: 52, Pages: 141-152, ISSN: 0197-4580

JOURNAL ARTICLE

Carayol M, Leitzmann MF, Ferrari P, Zamora-Ros R, Achaintre D, Stepien M, Schmidt JA, Travis RC, Overvad K, Tjonneland A, Hansen L, Kaaks R, Kuehn T, Boein H, Bachlechner U, Trichoroulou A, Bamia C, Palli D, Agnoli C, Tumino R, Vineis P, Panico S, Quiros JR, Sanchez-Cantalejo E, Huerta JM, Ardanaz E, Arriola L, Agudo A, Nilsson J, Melander E, Bueno-de-Mesquita B, Peeters PH, Wareham N, Khaw K-T, Jenab M, Key TJ, Scalbert A, Rinaldi Set al., 2017, Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort, JOURNAL OF PROTEOME RESEARCH, Vol: 16, Pages: 3137-3146, ISSN: 1535-3893

JOURNAL ARTICLE

Chatziioannou A, Georgiadis P, Hebels DG, Liampa I, Valavanis I, Bergdahl IA, Johansson A, Palli D, Chadeau-Hyam M, Siskos AP, Keun H, Botsivali M, de Kok TMCM, Perez AE, Kleinjans JCS, Vineis P, Kyrtopoulos SAet al., 2017, Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Duell EJ, Lujan-Barroso L, Sala N, McElyea SD, Overvad K, Tjonneland A, Olsen A, Weiderpass E, Busund L-T, Moi L, Muller D, Vineis P, Aune D, Matullo G, Naccarati A, Panico S, Tagliabue G, Tumino R, Palli D, Kaaks R, Katzke VA, Boeing H, Bueno-de-Mesquita HBA, Peeters PH, Trichopoulou A, Lagiou P, Kotanidou A, Travis RC, Wareham N, Khaw K-T, Quiros JR, Rodriguez-Barranco M, Dorronsoro M, Chirlaque M-D, Ardanaz E, Severi G, Boutron-Ruault M-C, Rebours V, Brennan P, Gunter M, Scelo G, Cote G, Sherman S, Korc Met al., 2017, Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study, INTERNATIONAL JOURNAL OF CANCER, Vol: 141, Pages: 905-915, ISSN: 0020-7136

JOURNAL ARTICLE

Ek WE, Tobi EW, Ahsan M, Lampa E, Ponzi E, Kyrtopoulos SA, Georgiadis P, Lumey LH, Heijmans BT, Botsivali M, Bergdahl IA, Karlsson T, Rask-Andersen M, Palli D, Ingelsson E, Hedman AK, Nilsson LM, Vineis P, Lind L, Flanagan JM, Johansson Aet al., 2017, Tea and coffee consumption in relation to DNA methylation in four European cohorts, HUMAN MOLECULAR GENETICS, Vol: 26, Pages: 3221-3231, ISSN: 0964-6906

JOURNAL ARTICLE

Fehringer G, Brenner DR, Zhang Z-F, Lee Y-CA, Matsuo K, Ito H, Lan Q, Vineis P, Johansson M, Overvad K, Riboli E, Trichopoulou A, Sacerdote C, Stucker I, Boffetta P, Brennan P, Christiani DC, Hong Y-C, Landi MT, Morgenstern H, Schwartz AG, Wenzlaff AS, Rennert G, McLaughlin JR, Harris CC, Olivo-Marston S, Orlow I, Park BJ, Zauderer M, Barros Dios JM, Ruano Ravina A, Siemiatycki J, Koushik A, Lazarus P, Fernandez-Somoano A, Tardon A, Le Marchand L, Brenner H, Saum K-U, Duell EJ, Andrew AS, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Holcatova I, Pesatori AC, Consonni D, Olsson A, Straif K, Hung RJet al., 2017, Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1976-1984, ISSN: 0020-7136

JOURNAL ARTICLE

Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, Demonet J-F, Garibotto V, Giannakopoulos P, Gietl A, Hansson O, Herholz K, Jack CR, Nobili F, Nordberg A, Snyder HM, Ten Kate M, Varrone A, Albanese E, Becker S, Bossuyt P, Carrillo MC, Cerami C, Dubois B, Gallo V, Giacobini E, Gold G, Hurst S, Loenneborg A, Lovblad K-O, Mattsson N, Molinuevo J-L, Monsch AU, Mosimann U, Padovani A, Picco A, Porteri C, Ratib O, Saint-Aubert L, Scerri C, Scheltens P, Schott JM, Sonni I, Teipel S, Vineis P, Visser PJ, Yasui Y, Winblad Bet al., 2017, Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers, LANCET NEUROLOGY, Vol: 16, Pages: 661-676, ISSN: 1474-4422

JOURNAL ARTICLE

Georgiadis P, Liampa I, Hebels DG, Krauskopf J, Chatziioannou A, Valavanis I, de Kok TMCM, Kleinjans JCS, Bergdahl IA, Melin B, Spaeth F, Palli D, Vermeulen RCH, Vlaanderen J, Chadeau-Hyam M, Vineis P, Kyrtopoulos SAet al., 2017, Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis, BMC GENOMICS, Vol: 18, ISSN: 1471-2164

JOURNAL ARTICLE

Gunter MJ, Murphy N, Cross AJ, Dossus L, Dartois L, Fagherazzi G, Kaaks R, Kuehn T, Boeing H, Aleksandrova K, Tjonneland A, Olsen A, Overvad K, Larsen SC, Redondo Cornejo ML, Agudo A, Sanchez Perez MJ, Altzibar JM, Navarro C, Ardanaz E, Khaw K-T, Butterworth A, Bradbury KE, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Grioni S, Vineis P, Panico S, Tumino R, Bueno-de-Mesquita B, Siersema P, Leenders M, Beulens JWJ, Uiterwaal CU, Wallstrom P, Nilsson LM, Landberg R, Weiderpass E, Skeie G, Braaten T, Brennan P, Licaj I, Muller DC, Sinha R, Wareham N, Riboli Eet al., 2017, Coffee Drinking and Mortality in 10 European Countries A Multinational Cohort Study, ANNALS OF INTERNAL MEDICINE, Vol: 167, Pages: 236-+, ISSN: 0003-4819

JOURNAL ARTICLE

Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa J-P, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas Het al., 2017, Roadmap for investigating epigenome deregulation and environmental origins of cancer., Int J Cancer

The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ("fingerprints") that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.

JOURNAL ARTICLE

Jay R, Brennan P, Brenner, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo Get al., 2017, Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559., Urol Oncol, Vol: 35

Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.

JOURNAL ARTICLE

Kelly RS, Kiviranta H, Bergdahl IA, Palli D, Johansson A-S, Botsivali M, Vineis P, Vermeulen R, Kyrtopoulos SA, Chadeau-Hyam Met al., 2017, Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study, ENVIRONMENTAL HEALTH, Vol: 16, ISSN: 1476-069X

JOURNAL ARTICLE

Kelly-Irving M, Delpierre C, Vineis P, 2017, Beyond bad luck: induced mutations and hallmarks of cancer, LANCET ONCOLOGY, Vol: 18, Pages: 999-1000, ISSN: 1470-2045

JOURNAL ARTICLE

Law PJ, Berndt SI, Speedy HE, Camp NJ, Sava GP, Skibola CF, Holroyd A, Joseph V, Sunter NJ, Nieters A, Bea S, Monnereau A, Martin-Garcia D, Goldin LR, Clot G, Teras LR, Quintela I, Birmann BM, Jayne S, Cozen W, Majid A, Smedby KE, Lan Q, Dearden C, Brooks-Wilson AR, Hall AG, Purdue MP, Mainou-Fowler T, Vajdic CM, Jackson GH, Cocco P, Marr H, Zhang Y, Zheng T, Giles GG, Lawrence C, Call TG, Liebow M, Melbye M, Glimelius B, Mansouri L, Glenn M, Curtin K, Diver WR, Link BK, Conde L, Bracci PM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Boffetta P, Brennan P, Maynadie M, McKay J, Albanes D, Weinstein S, Wang Z, Caporaso NE, Morton LM, Severson RK, Riboli E, Vineis P, Vermeulen RCH, Southey MC, Milne RL, Clavel J, Topka S, Spinelli JJ, Kraft P, Ennas MG, Summerfield G, Ferri GM, Harris RJ, Miligi L, Pettitt AR, North KE, Allsup DJ, Fraumeni JF, Bailey JR, Offit K, Pratt G, Hjalgrim H, Pepper C, Chanock SJ, Fegan C, Rosenquist R, de Sanjose S, Carracedo A, Dyer MJS, Catovsky D, Campo E, Cerhan JR, Allan JM, Rothman N, Houlston R, Slager SLet al., 2017, Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

McCrory C, O'Leary N, Fraga S, Ribeiro AI, Barros H, Kartiosuo N, Raitakari O, Kivimaki M, Vineis P, Layte Ret al., 2017, Socioeconomic differences in children's growth trajectories from infancy to early adulthood: evidence from four European countries, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 71, Pages: 981-989, ISSN: 0143-005X

JOURNAL ARTICLE

Mostafavi N, Vlaanderen J, Portengen L, Chadeau-Hyam M, Modig L, Palli D, Bergdahl IA, Brunekreef B, Vineis P, Hebels DGAJ, Kleinjans JCS, Krogh V, Hoek G, Georgiadis P, Kyrtopoulos S, Vermeulena Ret al., 2017, Associations between genome-wide gene expression and ambient nitrogen oxides, Epidemiology, Vol: 28, Pages: 320-328, ISSN: 1044-3983

Copyright © 2017 Wolters Kluwer Health, Inc. Background: We hypothesize that biological perturbations due to exposure to ambient air pollution are reflected in gene expression levels in peripheral blood mononuclear cells. Methods: We assessed the association between exposure to ambient air pollution and genome-wide gene expression levels in peripheral blood mononuclear cells collected from 550 healthy subjects participating in cohorts from Italy and Sweden. Annual air pollution estimates of nitrogen oxides (NOx) at time of blood collection (1990-2006) were available from the ESCAPE study. In addition to univariate analysis and two variable selection methods to investigate the association between expression and exposure to NOx, we applied gene set enrichment analysis to assess overlap between our most perturbed genes and gene sets hypothesized to be related to air pollution and cigarette smoking. Finally, we assessed associations between NOx and CpG island methylation at the identified genes. Results: Annual average NOx exposure in the Italian and Swedish cohorts was 94.2 and 6.7 μg/m3, respectively. Long-Term exposure to NOx was associated with seven probes in the Italian cohort and one probe in the Swedish (and combined) cohorts. For genes AHCYL2 and MTMR2, changes were also seen in the methylome . Genes hypothesized to be downregulated due to cigarette smoking were enriched among the most strongly downregulated genes from our study. Conclusion: This study provides evidence of subtle changes in gene expression related to exposure to long-Term NOx. On a global level, the observed changes in the transcriptome may indicate similarities between air pollution and tobacco induced changes in the transcriptome

JOURNAL ARTICLE

Mostafavi N, Vlaanderen J, Portengen L, Chadeau-Hyam M, Modig L, Palli D, Bergdahl IA, Brunekreef B, Vineis P, Hebels DGAJ, Kleinjans JCS, Krogh V, Hoek G, Georgiadis P, Kyrtopoulos SA, Vermeulen Ret al., 2017, Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides, EPIDEMIOLOGY, Vol: 28, Pages: 320-328, ISSN: 1044-3983

JOURNAL ARTICLE

Obon-Santacana M, Lujan-Barroso L, Freisling H, Cadeau C, Fagherazzi G, Boutron-Ruault M-C, Kaaks R, Fortner RT, Boeing H, Quiros JR, Molina-Montes E, Chamosa S, Castano JMH, Ardanaz E, Khaw K-T, Wareham N, Key T, Trichopoulou A, Lagiou P, Naska A, Palli D, Grioni S, Tumino R, Vineis P, De Magistris MS, Bueno-de-Mesquita HB, Peeters PH, Wennberg M, Bergdahl IA, Vesper H, Riboli E, Duell EJet al., 2017, Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort, EUROPEAN JOURNAL OF NUTRITION, Vol: 56, Pages: 1157-1168, ISSN: 1436-6207

JOURNAL ARTICLE

Pardini B, Viberti C, Naccarati A, Allione A, Oderda M, Critelli R, Preto M, Zijno A, Cucchiarale G, Gontero P, Vineis P, Sacerdote C, Matullo Get al., 2017, Increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of bladder cancer, BRITISH JOURNAL OF CANCER, Vol: 116, Pages: 202-210, ISSN: 0007-0920

JOURNAL ARTICLE

Pedersen M, Andersen ZJ, Stafoggia M, Weinmayre G, Galassi C, Sorensen M, Eriksen KT, Tjonneland A, Loft S, Jaensch A, Nagel G, Concin H, Tsai M-Y, Grioni S, Marcon A, Krogh V, Riccerin F, Sacerdote C, Ranzi A, Sokhi R, Vermeulen R, de Hoogh K, Wang M, Beelen R, Vineis P, Brunekreef B, Hoek G, Raaschou-Nielsen Oet al., 2017, Ambient air pollution and primary liver cancer incidence in four European cohorts within the ESCAPE project, ENVIRONMENTAL RESEARCH, Vol: 154, Pages: 226-233, ISSN: 0013-9351

JOURNAL ARTICLE

Perez-Cornago A, Appleby PN, Tipper S, Key TJ, Allen NE, Nieters A, Vermeulen R, Roulland S, Casabonne D, Kaaks R, Fortner RT, Boeing H, Trichopoulou A, La Vecchia C, Klinaki E, Hansen L, Tjonneland A, Bonnet F, Fagherazzi G, Boutron-Ruault M-C, Pala V, Masala G, Sacerdote C, Peeters PH, Bueno-de-Mesquita HBA, Weiderpass E, Dorronsoro M, Quiros JR, Barricarte A, Gavrila D, Agudo A, Borgquist S, Rosendahl AH, Melin B, Wareham N, Khaw K-T, Gunter M, Riboli E, Vineis P, Travis RCet al., 2017, Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1111-1118, ISSN: 0020-7136

JOURNAL ARTICLE

Plusquin M, Guida F, Polidoro S, Vermeulen R, Raaschou-Nielsen O, Campanella G, Hoek G, Kyrtopoulos SA, Georgiadis P, Naccarati A, Sacerdote C, Krogh V, Bas Bueno-de-Mesquita H, Monique Verschuren WM, Sayols-Baixeras S, Panni T, Peters A, Hebels DGAJ, Kleinjans J, Vineis P, Chadeau-Hyam Met al., 2017, DNA methylation and exposure to ambient air pollution in two prospective cohorts., Environ Int, Vol: 108, Pages: 127-136

Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further investigated. The aim of this study is to investigate the effects of long-term exposure to air pollutants on (a) average DNA methylation at functional regions and, (b) individual differentially methylated CpG sites. An assumption is that omic measurements, including the methylome, are more sensitive to low doses than hard health outcomes. This study included blood-derived DNA methylation (Illumina-HM450 methylation) for 454 Italian and 159 Dutch participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). Long-term air pollution exposure levels, including NO2, NOx, PM2.5, PMcoarse, PM10, PM2.5 absorbance (soot) were estimated using models developed within the ESCAPE project, and back-extrapolated to the time of sampling when possible. We meta-analysed the associations between the air pollutants and global DNA methylation, methylation in functional regions and epigenome-wide methylation. CpG sites found differentially methylated with air pollution were further investigated for functional interpretation in an independent population (EnviroGenoMarkers project), where (N=613) participants had both methylation and gene expression data available. Exposure to NO2 was associated with a significant global somatic hypomethylation (p-value=0.014). Hypomethylation of CpG island's shores and shelves and gene bodies was significantly associated with higher exposures to NO2 and NOx. Meta-analysing the epigenome-wide findings of the 2 cohorts did not show genome-wide significant associations at single CpG site level. However, several significant CpG were found if the analyses were separated by countries. By regressing gene expression levels against methylation levels of the exposure-related CpG sites, we identified several significant CpG-tr

JOURNAL ARTICLE

Raaschou-Nielsen O, Pedersen M, Stafoggia M, Weinmayr G, Andersen ZJ, Galassi C, Sommar J, Forsberg B, Olsson D, Oftedal B, Krog NH, Aasvang GM, Pyko A, Pershagen G, Korek M, De Faire U, Pedersen NL, OEstenson C-G, Fratiglioni L, Sorensen M, Eriksen KT, Tjonneland A, Peeters PH, Bueno-de-Mesquita HBA, Plusquin M, Key TJ, Jaensch A, Nagel G, Foeger B, Wang M, Tsai M-Y, Grioni S, Marcon A, Krogh V, Ricceri F, Sacerdote C, Migliore E, Tamayo I, Amiano P, Dorronsoro M, Sokhi R, Kooter I, de Hoogh K, Beelen R, Eeftens M, Vermeulen R, Vineis P, Brunekreef B, Hoek Get al., 2017, Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1528-1537, ISSN: 0020-7136

JOURNAL ARTICLE

Romieu I, Ferrari P, Chajes V, de Batlle J, Biessy C, Scoccianti C, Dossus L, Boutron MC, Bastide N, Overvad K, Olsen A, Tjonneland A, Kaaks R, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Sieri S, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita HBA, Gils CH, Peeters PH, Lund E, Skeie G, Weiderpass E, Quiros JR, Chirlaque M-D, Ardanaz E, Sanchez M-J, Duell EJ, Etxezarreta PA, Borgquist S, Hallmans G, Johansson I, Nilsson LM, Khaw K-T, Wareham N, Key TJ, Travis RC, Murphy N, Wark PA, Riboli Eet al., 2017, Fiber intake modulates the association of alcohol intake with breast cancer, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 316-321, ISSN: 0020-7136

JOURNAL ARTICLE

Scheelbeek P, Chowdhury MAH, Haines A, Alam D, Hoque MA, Butler AP, Khan AE, Mojumder SK, Blangiardo MAG, Elliott P, Vineis Pet al., 2017, Drinking Water Salinity and Raised Blood Pressure: Evidence from a Cohort Study in Coastal Bangladesh., Environ Health Perspect, Vol: 125

BACKGROUND: Millions of coastal inhabitants in Southeast Asia have been experiencing increasing sodium concentrations in their drinking-water sources, likely partially due to climate change. High (dietary) sodium intake has convincingly been proven to increase risk of hypertension; it remains unknown, however, whether consumption of sodium in drinking water could have similar effects on health. OBJECTIVES: We present the results of a cohort study in which we assessed the effects of drinking-water sodium (DWS) on blood pressure (BP) in coastal populations in Bangladesh. METHODS: DWS, BP, and information on personal, lifestyle, and environmental factors were collected from 581 participants. We used generalized linear latent and mixed methods to model the effects of DWS on BP and assessed the associations between changes in DWS and BP when participants experienced changing sodium levels in water, switched from "conventional" ponds or tube wells to alternatives [managed aquifer recharge (MAR) and rainwater harvesting] that aimed to reduce sodium levels, or experienced a combination of these changes. RESULTS: DWS concentrations were highly associated with BP after adjustments for confounding factors. Furthermore, for each 100 mg/L reduction in sodium in drinking water, systolic/diastolic BP was lower on average by 0.95/0.57 mmHg, and odds of hypertension were lower by 14%. However, MAR did not consistently lower sodium levels. CONCLUSIONS: DWS is an important source of daily sodium intake in salinity-affected areas and is a risk factor for hypertension. Considering the likely increasing trend in coastal salinity, prompt action is required. Because MAR showed variable effects, alternative technologies for providing reliable, safe, low-sodium fresh water should be developed alongside improvements in MAR and evaluated in "real-life" salinity-affected settings. https://doi.org/10.1289/EHP659.

JOURNAL ARTICLE

Stringhini S, Carmeli C, Jokela M, Avendano M, Muennig P, Guida F, Ricceri F, d'Errico A, Barros H, Bochud M, Chadeau-Hyam M, Clavel-Chapelon F, Costa G, Delpierre C, Fraga S, Goldberg M, Giles GG, Krogh V, Kelly-Irving M, Layte R, Lasserre AM, Marmot MG, Preisig M, Shipley MJ, Vollenweider P, Zins M, Kawachi I, Steptoe A, Mackenbach JP, Vineis P, Kivimaki Met al., 2017, Socioeconomic status and the 25 x 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1.7 million men and women, LANCET, Vol: 389, Pages: 1229-1237, ISSN: 0140-6736

JOURNAL ARTICLE

Vineis P, 2017, A defense of the Precautionary Principle, EPIDEMIOLOGIA & PREVENZIONE, Vol: 41, Pages: 6-8, ISSN: 1120-9763

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00345466&limit=30&person=true