Publications
1358 results found
Baussano I, Ronco G, Segnan N, et al., 2010, HPV-16 infection and cervical cancer: Modeling the influence of duration of infection and precancerous lesions, EPIDEMICS, Vol: 2, Pages: 21-28, ISSN: 1755-4365
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- Citations: 22
Hosnijeh FS, Krop EJM, Portengen L, et al., 2010, Stability and reproducibility of simultaneously detected plasma and serum cytokine levels in asymptomatic subjects, BIOMARKERS, Vol: 15, Pages: 140-148, ISSN: 1354-750X
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- Citations: 38
Hoeft B, Linseisen J, Beckmann L, et al., 2010, Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk, CARCINOGENESIS, Vol: 31, Pages: 466-472, ISSN: 0143-3334
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- Citations: 53
Ricceri F, Guarrera S, Sacerdote C, et al., 2010, <i>ERCC1</i> haplotypes modify bladder cancer risk: A case-control study, DNA REPAIR, Vol: 9, Pages: 191-200, ISSN: 1568-7864
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- Citations: 28
Wolpin BM, Kraft P, Gross M, et al., 2010, Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium, CANCER RESEARCH, Vol: 70, Pages: 1015-1023, ISSN: 0008-5472
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- Citations: 160
Rundle A, Richie J, Steindorf K, et al., 2010, Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC, BIOMARKERS, Vol: 15, Pages: 20-30, ISSN: 1354-750X
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- Citations: 12
Jenab M, Bueno-de-Mesquita HB, Ferrari P, et al., 2010, Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study, British Medical Journal, Vol: 340, ISSN: 1468-5833
Objective To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations.Design Nested case-control study.Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries.Participants 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controlsMain outcome measures Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders.Results 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); ≥100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were n
Vineis P, 2010, The Research Program in Epigenetics: The Birth of a New Paradigm, Epigenetics and Human Health: Linking Hereditary, Environmental and Nutritional Aspects, Pages: 1-6, ISBN: 9783527324279
This introductory chapter sketches a short history of the concept of epigenetics, from Waddington to today. The chapter outlines the promises associated with the development of epigenetic research, particularly in the field of cancer, and the stillunmet challenges, with several examples. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Vineis P, Baccarelli A, 2010, Gene-environment interactions, genome-wide studies, epigenetics: the new challenges, EPIDEMIOLOGIA & PREVENZIONE, Vol: 34, Pages: 68-71, ISSN: 1120-9763
Eussen SJPM, Vollset SE, Hustad S, et al., 2010, Vitamins B2 and B6 and Genetic Polymorphisms Related to One-Carbon Metabolism as Risk Factors for Gastric Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 19, Pages: 28-38, ISSN: 1055-9965
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- Citations: 31
Michaud DS, Gallo V, Schlehofer B, et al., 2010, Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study, Vol: 19, Pages: 2562-2569, ISSN: 1538-7755
BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46). CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation. IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.
Weisskopf MG, Gallo V, O'Reilly EJ, et al., 2010, Smoking may be considered an established risk factor for sporadic ALS, Vol: 74, Pages: 1927-1928, ISSN: 1526-632X
Vrieling A, Bueno-de-Mesquita HB, Boshuizen HC, et al., 2010, Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition, Vol: 126, Pages: 2394-2403, ISSN: 1097-0215
Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% CI = 1.36-2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% CI = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% CI = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% CI = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.
Dossus L, Allen N, Kaaks R, et al., 2010, Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition, Vol: 127, Pages: 442-451, ISSN: 1097-0215
Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis.
Hermann S, Rohrmann S, Linseisen J, et al., 2010, Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition, Vol: 136, Pages: 71-77, ISSN: 1432-1335
INTRODUCTION: Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. MATERIALS AND METHODS: Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. RESULTS: Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. CONCLUSION: We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded.
Gallo V, Neasham D, Airoldi L, et al., 2010, Second-hand smoke, cotinine levels, and risk of circulatory mortality in a large cohort study of never-smokers, Vol: 21, Pages: 207-214, ISSN: 1531-5487
BACKGROUND: Exposure to second-hand smoke has been shown to be associated with increased cardiovascular mortality in several, but not all, epidemiologic studies. Our aim was to investigate the risk of circulatory death associated with exposure to second-hand smoke in never-smokers in a very large prospective study, the European Prospective Investigation into Cancer and Nutrition. A secondary aim was to use cotinine levels for cross-validating self-reported second-hand smoke exposure. METHODS: Cox proportional hazard models were used to investigate the risk of death due to circulatory causes associated with second-hand smoke exposure in 135,233 never-smokers. Exposure to second-hand smoke was assessed through a questionnaire at enrollment and then validated against plasma cotinine measurements in a subsample. RESULTS: Study participants who reported second-hand smoke exposure at home had higher cotinine levels (median plasma cotinine concentration in exposed = 0.82 microg/L; in those unexposed 0.02 microg/L). Second-hand smoke exposure at home was associated with an increased risk of dying from cardiovascular diseases (hazard ratio [HR] = 1.38 [95% confidence interval = 1.01-1.90]), all circulatory diseases (1.28 [0.98-1.69]), and coronary heart disease (1.31 [0.83-2.08]) after adjustment for age, sex, education, physical activity, and body mass index. Dose-response relationships were observed between exposure to second-hand smoke at home and risk of circulatory death (HR per each additional hour/d = 1.25 [1.04-1.50]). Having a partner who smokes more than 30 cigarettes per day considerably increased the risk of a circulatory death (2.94 [1.11-7.78]). Second-hand smoke exposure at home was not associated with total mortality (1.03 [0.93-1.13]). DISCUSSION: Exposure to second-hand smoke at home (as confirmed by plasma cotinine levels) increases the risk of cardiovascular mortality.
Michaud DS, Gallo V, Schlehofer B, et al., 2010, Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study, Vol: 92, Pages: 1145-1150, ISSN: 1938-3207
BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. RESULTS: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming >/=100 mL coffee and tea per day compared with those consuming <100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. CONCLUSIONS: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.
Price AJ, Allen NE, Appleby PN, et al., 2010, Plasma phytanic acid concentration and risk of prostate cancer: results from the European Prospective Investigation into Cancer and Nutrition, Vol: 91, Pages: 1769-1776, ISSN: 1938-3207
BACKGROUND: Phytanic acid, a fatty acid predominantly obtained from foods high in ruminant fat, may have a biological role in the up-regulation of the protein alpha-methylacyl-coenzyme A racemase, which is overexpressed in prostate cancer tissue. OBJECTIVE: This study aimed to examine the association between plasma concentrations of phytanic acid and subsequent risk of prostate cancer. DESIGN: Within the European Prospective Investigation into Cancer and Nutrition cohort, 566 incident prostate cancer cases from Germany, Greece, Italy, the Netherlands, Spain, and the United Kingdom were individually matched to 566 controls by study center, age at recruitment, and time of day and duration of fasting at blood collection. Phytanic acid concentrations were measured by using a gas chromatography-mass spectrometry assay. RESULTS: In controls, plasma phytanic acid concentration was strongly correlated with dairy fat intake (r = 0.49, P < 0.0001), varied significantly by country (P for heterogeneity < 0.0001), and decreased with age (P for trend = 0.02) and duration of fasting at blood collection (P for trend = 0.002). There was no significant association of phytanic acid with prostate cancer risk overall (odds ratio for a doubling in concentration: 1.05; 95% CI: 0.91, 1.21; P for trend = 0.53) or by stage or grade of disease. However, in men who had fasted (>3 h) at blood collection, the odds ratio for prostate cancer was 1.27 (95% CI: 1.01, 1.60; P for trend = 0.04). CONCLUSION: Plasma phytanic acid concentration is significantly associated with intake of dairy fat but not with overall risk of prostate cancer in this European population.
Menvielle G, Boshuizen H, Kunst AE, et al., 2010, Occupational exposures contribute to educational inequalities in lung cancer incidence among men: Evidence from the EPIC prospective cohort study, Vol: 126, Pages: 1928-1935, ISSN: 1097-0215
The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses were based on a subsample of the European Prospective Investigation into Cancer and Nutrition (EPIC study), a prospective cohort. The analyses included 703 incident lung cancer cases among men in Denmark, the United Kingdom, Germany, Italy, Spain and Greece. The socioeconomic position was measured using the highest level of education. The estimates of relative indices of inequality (RII) were computed with Cox regression models. We first adjusted for smoking (with detailed information on duration and quantity) and dietary factors (fruits and vegetables consumption) and then for occupational exposures. The exposure to three carcinogens [asbestos, heavy metals and polycyclic aromatic hydrocarbons (PAH)] was analyzed. The occupational exposures explained 14% of the socioeconomic inequalities remaining after adjustment for smoking and fruits and vegetables consumption. The inequalities remained nevertheless statistically significant. The RII decreased from 1.87 (95% CI: 1.36-2.56) to 1.75 (1.27-2.41). The decrease was more pronounced when adjusting for asbestos than for heavy metals or PAH. Analyses by birth cohort suggested an effect of occupational exposures among older men, while due to small number of endpoints, no conclusion could be drawn about the role of occupational exposures in educational inequalities among younger men. Our study revealed that the impact of occupational exposures on socioeconomic inequalities in cancer incidence, rarely studied until now, exists while of modest magnitude.
De Marco L, Gillio-Tos A, Fiano V, et al., 2009, Occult HCV Infection: An Unexpected Finding in a Population Unselected for Hepatic Disease, PLOS ONE, Vol: 4, ISSN: 1932-6203
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- Citations: 62
Buechner FL, Bueno-de-Mesquita HB, Ros MM, et al., 2009, Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 125, Pages: 2643-2651, ISSN: 0020-7136
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- Citations: 33
Blair A, Saracci R, Vineis P, et al., 2009, Epidemiology, Public Health, and the Rhetoric of False Positives, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 117, Pages: 1809-1813, ISSN: 0091-6765
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- Citations: 48
Vineis P, Khan AE, Vlaanderen J, et al., 2009, The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability, ENVIRONMENTAL HEALTH, Vol: 8
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- Citations: 46
Vineis P, 2009, Expectations from the application of -omics to longitudinal studies: examples, MUTAGENESIS, Vol: 24, Pages: 535-535, ISSN: 0267-8357
Travier N, Agudo A, May AM, et al., 2009, Smoking and body fatness measurements: A cross-sectional analysis in the EPIC-PANACEA study, PREVENTIVE MEDICINE, Vol: 49, Pages: 365-373, ISSN: 0091-7435
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- Citations: 22
Travis RC, Schumacher F, Hirschhorn JN, et al., 2009, <i>CYP19A1</i> Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 18, Pages: 2734-2744, ISSN: 1055-9965
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- Citations: 29
Lambert J-C, Heath S, Even G, et al., 2009, Genome-wide association study identifies variants at <i>CLU</i> and <i>CR1</i> associated with Alzheimer's disease, NATURE GENETICS, Vol: 41, Pages: 1094-U68, ISSN: 1061-4036
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- Citations: 1856
Gallo V, Vineis P, Riboli E, et al., 2009, The large- scale European prospective investigation into cancer and nutrition (EPIC) unravels risk factors for ALS, 13th Congress of the European-Federation-of-Neurological-Societies, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 218-218, ISSN: 1351-5101
Wu X, Ye Y, Kiemeney LA, et al., 2009, Genetic variation in the prostate stem cell antigen gene <i>PSCA</i> confers susceptibility to urinary bladder cancer (vol 41, pg 991, 2009), NATURE GENETICS, Vol: 41, Pages: 1156-1156, ISSN: 1061-4036
Mirabelli MC, Zock J-P, D'Errico A, et al., 2009, Occupational Exposure to High Molecular Weight Allergens and Lymphoma Risk Among Italian Adults, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 18, Pages: 2650-2654, ISSN: 1055-9965
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- Citations: 10
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