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@article{Jeong:2018:10.1016/j.envint.2018.06.025,
author = {Jeong, A and Fiorito, G and Keski-Rahkonen, P and Imboden, M and Kiss, A and Robinot, N and Gmuender, H and Vlaanderen, J and Vermeulen, R and Kyrtopoulos, S and Herceg, Z and Ghantous, A and Lovison, G and Galassi, C and Ranzi, A and Krogh, V and Grioni, S and Agnoli, C and Sacerdote, C and Mostafavi, N and Naccarati, A and Scalbert, A and Vineis, P and Probst-Hensch, N and EXPOsOMICS, Consortium},
doi = {10.1016/j.envint.2018.06.025},
journal = {Environment International},
pages = {334--345},
title = {Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases},
url = {http://dx.doi.org/10.1016/j.envint.2018.06.025},
volume = {119},
year = {2018}
}

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TY  - JOUR
AB  - BACKGROUND: Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of common altered molecular pathways. OBJECTIVES: The goal was to find intermediate metabolites or metabolic pathways that could be associated with both air pollutants and health outcomes ("meeting-in-the-middle"), thus shedding light on mechanisms and reinforcing causality. METHODS: We applied a statistical approach named 'meet-in-the-middle' to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases (CCVD). We compared the results to identify both common and disease-specific altered metabolic pathways. RESULTS: A novel finding was a strong association of AOA with ultrafine particles (UFP; odds ratio 1.80 [1.26, 2.55] per increase by 5000particles/cm3). Further, we have identified several metabolic pathways that potentially mediate the effect of air pollution on health outcomes. Among those, perturbation of Linoleate metabolism pathway was associated with air pollution exposure, AOA and CCVD. CONCLUSIONS: Our results suggest common pathway perturbations may occur as a consequence of chronic exposure to air pollution leading to increased risk for both AOA and CCVD.
AU  - Jeong,A
AU  - Fiorito,G
AU  - Keski-Rahkonen,P
AU  - Imboden,M
AU  - Kiss,A
AU  - Robinot,N
AU  - Gmuender,H
AU  - Vlaanderen,J
AU  - Vermeulen,R
AU  - Kyrtopoulos,S
AU  - Herceg,Z
AU  - Ghantous,A
AU  - Lovison,G
AU  - Galassi,C
AU  - Ranzi,A
AU  - Krogh,V
AU  - Grioni,S
AU  - Agnoli,C
AU  - Sacerdote,C
AU  - Mostafavi,N
AU  - Naccarati,A
AU  - Scalbert,A
AU  - Vineis,P
AU  - Probst-Hensch,N
AU  - EXPOsOMICS,Consortium
DO  - 10.1016/j.envint.2018.06.025
EP  - 345
PY  - 2018///
SN  - 0160-4120
SP  - 334
TI  - Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2018.06.025
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29990954
UR  - http://hdl.handle.net/10044/1/61686
VL  - 119
ER  -

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