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@article{Porta:2021:ije/dyab115,
author = {Porta, M and Gasull, M and Pumarega, J and Kiviranta, H and Rantakokko, P and Raaschou-Nielsen, O and Bergdahl, IA and Sandanger, TM and Agudo, A and Rylander, C and Nøst, TH and Donat-Vargas, C and Aune, D and Heath, AK and Cirera, L and Goñi-Irigoyen, F and Alguacil, J and Giménez-Robert, À and Tjønneland, A and Sund, M and Overvad, K and Mancini, FR and Rebours, V and Boutron-Ruault, M-C and Kaaks, R and Schulze, MB and Trichopoulou, A and Palli, D and Grioni, S and Tumino, R and Naccarati, A and Panico, S and Vermeulen, R and Quirós, JR and Rodríguez-Barranco, M and Colorado-Yohar, SM and Chirlaque, M-D and Ardanaz, E and Wareham, N and Key, T and Johansson, M and Murphy, N and Ferrari, P and Huybrechts, I and Chajes, V and Gonzalez, CA and de-Mesquita, BB and Gunter, M and Weiderpass, E and Riboli, E and Duell, EJ and Katzke, V and Vineis, P},
doi = {ije/dyab115},
journal = {International Journal of Epidemiology},
pages = {1--12},
title = {Plasma concentrations of persistent organic pollutants and pancreatic cancer risk},
url = {http://dx.doi.org/10.1093/ije/dyab115},
volume = {00},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundFindings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.MethodsWe conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.ResultsSome associations were observed at higher concentrations of p, p’-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.ConclusionsIndividually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
AU  - Porta,M
AU  - Gasull,M
AU  - Pumarega,J
AU  - Kiviranta,H
AU  - Rantakokko,P
AU  - Raaschou-Nielsen,O
AU  - Bergdahl,IA
AU  - Sandanger,TM
AU  - Agudo,A
AU  - Rylander,C
AU  - Nøst,TH
AU  - Donat-Vargas,C
AU  - Aune,D
AU  - Heath,AK
AU  - Cirera,L
AU  - Goñi-Irigoyen,F
AU  - Alguacil,J
AU  - Giménez-Robert,À
AU  - Tjønneland,A
AU  - Sund,M
AU  - Overvad,K
AU  - Mancini,FR
AU  - Rebours,V
AU  - Boutron-Ruault,M-C
AU  - Kaaks,R
AU  - Schulze,MB
AU  - Trichopoulou,A
AU  - Palli,D
AU  - Grioni,S
AU  - Tumino,R
AU  - Naccarati,A
AU  - Panico,S
AU  - Vermeulen,R
AU  - Quirós,JR
AU  - Rodríguez-Barranco,M
AU  - Colorado-Yohar,SM
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Wareham,N
AU  - Key,T
AU  - Johansson,M
AU  - Murphy,N
AU  - Ferrari,P
AU  - Huybrechts,I
AU  - Chajes,V
AU  - Gonzalez,CA
AU  - de-Mesquita,BB
AU  - Gunter,M
AU  - Weiderpass,E
AU  - Riboli,E
AU  - Duell,EJ
AU  - Katzke,V
AU  - Vineis,P
DO  - ije/dyab115
EP  - 12
PY  - 2021///
SN  - 0300-5771
SP  - 1
TI  - Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
T2  - International Journal of Epidemiology
UR  - http://dx.doi.org/10.1093/ije/dyab115
UR  - https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyab115/6321178
UR  - http://hdl.handle.net/10044/1/90422
VL  - 00
ER  -

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