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@article{Romieu:2016:10.1002/ijc.30415,
author = {Romieu, I and Ferrari, P and Chajès, V and de, Batlle J and Biessy, C and Scoccianti, C and Dossus, L and Boutron, MC and Bastide, N and Overvad, K and Olsen, A and Tjønneland, A and Kaaks, R and Boeing, H and Trichopoulou, A and Lagiou, P and Trichopoulos, D and Palli, D and Sieri, S and Tumino, R and Vineis, P and Panico, S and Bueno-de-Mesquita, HB and Gils, CH and Peeters, PH and Lund, E and Skeie, G and Weiderpass, E and Quirós, JR and Chirlaque, MD and Ardanaz, E and Sánchez, MJ and Duell, EJ and Amiano, Etxezarreta P and Borgquist, S and Hallmans, G and Johansson, I and Nilsson, LM and Khaw, KT and Wareham, N and Key, TJ and Travis, RC and Murphy, N and Wark, PA and Riboli, E},
doi = {10.1002/ijc.30415},
journal = {International Journal of Cancer},
pages = {316--321},
title = {Fiber intake modulates the association of alcohol intake with breast cancer},
url = {http://dx.doi.org/10.1002/ijc.30415},
volume = {140},
year = {2016}
}

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TY  - JOUR
AB  - Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and breast cancer using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive breast cancer according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p=0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC.
AU  - Romieu,I
AU  - Ferrari,P
AU  - Chajès,V
AU  - de,Batlle J
AU  - Biessy,C
AU  - Scoccianti,C
AU  - Dossus,L
AU  - Boutron,MC
AU  - Bastide,N
AU  - Overvad,K
AU  - Olsen,A
AU  - Tjønneland,A
AU  - Kaaks,R
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Trichopoulos,D
AU  - Palli,D
AU  - Sieri,S
AU  - Tumino,R
AU  - Vineis,P
AU  - Panico,S
AU  - Bueno-de-Mesquita,HB
AU  - Gils,CH
AU  - Peeters,PH
AU  - Lund,E
AU  - Skeie,G
AU  - Weiderpass,E
AU  - Quirós,JR
AU  - Chirlaque,MD
AU  - Ardanaz,E
AU  - Sánchez,MJ
AU  - Duell,EJ
AU  - Amiano,Etxezarreta P
AU  - Borgquist,S
AU  - Hallmans,G
AU  - Johansson,I
AU  - Nilsson,LM
AU  - Khaw,KT
AU  - Wareham,N
AU  - Key,TJ
AU  - Travis,RC
AU  - Murphy,N
AU  - Wark,PA
AU  - Riboli,E
DO  - 10.1002/ijc.30415
EP  - 321
PY  - 2016///
SN  - 1097-0215
SP  - 316
TI  - Fiber intake modulates the association of alcohol intake with breast cancer
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.30415
UR  - http://hdl.handle.net/10044/1/40269
VL  - 140
ER  -

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