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@article{Riboli:2016:10.1002/ijc.30528,
author = {Riboli, E and Vineis and Peeters},
doi = {10.1002/ijc.30528},
journal = {International Journal of Cancer},
pages = {1111--1118},
title = {Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition},
url = {http://dx.doi.org/10.1002/ijc.30528},
volume = {140},
year = {2016}
}

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TY  - JOUR
AB  - Insulin-like growth factor-I (IGF-I) has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not  been  examined  prospectively.  IGF-I  concentration  was  measured  in  pre-diagnostic  plasma  samples  from  a  nested  case-control  study  of  1072  cases  of  lymphoid  malignancies  and  1072  individually  matched  controls  from  the  European  Prospective  Investigation  into  Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall  lymphoma  risk  (multivariable-adjusted  OR  for  highest  versus  lowest  third  =  0.77  [95% CI=0.57-1.03], Ptrend = 0.06). There was no statistical evidence of heterogeneity in this association  with  IGF-I  by  sex,  age  at  blood  collection,  time  between  blood  collection  and  diagnosis,  age  at  diagnosis,  or  body  mass  index  (Pheterogeneity  for  all  ≥  0.05).  There  were  no  associations   between   IGF-I   concentration   and   risk   for   specific   BCL   subtypes,   T-cell   lymphoma  or  Hodgkin  lymphoma,  although  number  of  cases  were  small.  In  this  European  population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides  the  first  prospective  evidence  on  circulating  IGF-I  concentrations  and  risk  of  lymphoma.   Further   prospective   data   are   required   to   examine   associations   of   IGF-I   concentrations with lymphoma subtypes.
AU  - Riboli,E
AU  - Vineis
AU  - Peeters
DO  - 10.1002/ijc.30528
EP  - 1118
PY  - 2016///
SN  - 1097-0215
SP  - 1111
TI  - Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.30528
UR  - http://hdl.handle.net/10044/1/42287
VL  - 140
ER  -

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