Imperial College London
Alternate

ProfessorPaoloVineis

Faculty of Medicine, School of Public Health

Chair in Environmental Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
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Location

 

511Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Law:2017:10.1038/ncomms14175,
author = {Law, PJ and Berndt, SI and Speedy, HE and Camp, NJ and Sava, GP and Skibola, CF and Holroyd, A and Joseph, V and Sunter, NJ and Nieters, A and Bea, S and Monnereau, A and Martin-Garcia, D and Goldin, LR and Clot, G and Teras, LR and Quintela, I and Birmann, BM and Jayne, S and Cozen, W and Majid, A and Smedby, KE and Dearden, C and Brooks-Wilson, AR and Hall, AG and Purdue, MP and Mainou-Fowler, T and Vajdic, CM and Jackson, GH and Cocco, P and Marr, H and Zhang, Y and Zheng, T and Giles, GG and Lawrence, C and Call, TG and Liebow, M and Melbye, M and Glimelius, B and Mansouri, L and Glenn, M and Curtin, K and Diver, WR and Link, BK and Conde, L and Bracci, PM and Holly, EA and Jackson, RD and Tinker, LF and Benavente, Y and Boffetta, P and Brennan, P and Maynadie, M and McKay, J and Albanes, D and Weinstein, S and Wang, Z and Caporaso, NE and Morton, LM and Severson, RK and Riboli, E and Vineis, P and Vermeulen, RCH and Southey, MC and Milne, RL and Clavel, J and Topka, S and Spinelli},
doi = {10.1038/ncomms14175},
journal = {Nature Communications},
title = {Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia},
url = {http://dx.doi.org/10.1038/ncomms14175},
volume = {8},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Several chronic lymphocytic leukemia (CLL) susceptibility loci have been reported, however much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1000 Genomes and UK10K data, totaling 6,200 cases and 17,598 controls after replication. We identify nine  risk loci at 1p36.11 (rs34676223, P = 5.04x10-13), 1q42.13 (rs41271473, P = 1.06x10-10), 4q24 (rs71597109, P = 1.37x10-10), 4q35.1 (rs57214277, P = 3.69x10-8), 6p21.31 (rs3800461, P = 1.97x10-8), 11q23.2 (rs61904987, P = 2.64x10-11), 18q21.1 (rs1036935, P = 3.27x10-8), 19p13.3 (rs7254272, P = 4.67x10-8) and 22q13.33 (rs140522, P = 2.70x10-9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for key determinants of B-cell development and immune response.
AU  - Law,PJ
AU  - Berndt,SI
AU  - Speedy,HE
AU  - Camp,NJ
AU  - Sava,GP
AU  - Skibola,CF
AU  - Holroyd,A
AU  - Joseph,V
AU  - Sunter,NJ
AU  - Nieters,A
AU  - Bea,S
AU  - Monnereau,A
AU  - Martin-Garcia,D
AU  - Goldin,LR
AU  - Clot,G
AU  - Teras,LR
AU  - Quintela,I
AU  - Birmann,BM
AU  - Jayne,S
AU  - Cozen,W
AU  - Majid,A
AU  - Smedby,KE
AU  - Dearden,C
AU  - Brooks-Wilson,AR
AU  - Hall,AG
AU  - Purdue,MP
AU  - Mainou-Fowler,T
AU  - Vajdic,CM
AU  - Jackson,GH
AU  - Cocco,P
AU  - Marr,H
AU  - Zhang,Y
AU  - Zheng,T
AU  - Giles,GG
AU  - Lawrence,C
AU  - Call,TG
AU  - Liebow,M
AU  - Melbye,M
AU  - Glimelius,B
AU  - Mansouri,L
AU  - Glenn,M
AU  - Curtin,K
AU  - Diver,WR
AU  - Link,BK
AU  - Conde,L
AU  - Bracci,PM
AU  - Holly,EA
AU  - Jackson,RD
AU  - Tinker,LF
AU  - Benavente,Y
AU  - Boffetta,P
AU  - Brennan,P
AU  - Maynadie,M
AU  - McKay,J
AU  - Albanes,D
AU  - Weinstein,S
AU  - Wang,Z
AU  - Caporaso,NE
AU  - Morton,LM
AU  - Severson,RK
AU  - Riboli,E
AU  - Vineis,P
AU  - Vermeulen,RCH
AU  - Southey,MC
AU  - Milne,RL
AU  - Clavel,J
AU  - Topka,S
AU  - Spinelli,JJ
AU  - Kraft,P
AU  - Grazia,Ennas M
AU  - Summerfield,G
AU  - Ferri,GM
AU  - Harris,RJ
AU  - Miligi,L
AU  - Pettitt,AR
AU  - North,KE
AU  - Allsup,DJ
AU  - Fraumeni,JF
AU  - Bailey,JR
AU  - Offit,K
AU  - Pratt,G
AU  - Hjalgrim,H
AU  - Pepper,C
AU  - Chanock,SJ
AU  - Fegan,C
AU  - Rosenquist,R
AU  - de,Sanjose S
AU  - Carracedo,A
AU  - Dyer,MJS
AU  - Catovsky,D
AU  - Campo,E
AU  - Cerhan,JR
AU  - Allan,JM
AU  - Rothman,N
AU  - Houlston,R
AU  - Slager,S
DO  - 10.1038/ncomms14175
PY  - 2017///
SN  - 2041-1723
TI  - Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms14175
UR  - http://hdl.handle.net/10044/1/43261
VL  - 8
ER  -
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