Publications

BibTex format

@article{Mostafavi:2017:10.1097/EDE.0000000000000628,
author = {Mostafavi, N and Vlaanderen, J and Portengen, L and Chadeau-Hyam, M and Modig, L and Palli, D and Bergdahl, IA and Brunekreef, B and Vineis, P and Hebels, DGAJ and Kleinjans, JCS and Krogh, V and Hoek, G and Georgiadis, P and Kyrtopoulos, S and Vermeulena, R},
doi = {10.1097/EDE.0000000000000628},
journal = {Epidemiology},
pages = {320--328},
title = {Associations between genome-wide gene expression and ambient nitrogen oxides},
url = {http://dx.doi.org/10.1097/EDE.0000000000000628},
volume = {28},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: We hypothesize that biological perturbations due to exposure to ambient air pollution are reflected in gene expression levels in peripheral blood mononuclear cells. Methods: We assessed the association between exposure to ambient air pollution and genome-wide gene expression levels in peripheral blood mononuclear cells collected from 550 healthy subjects participating in cohorts from Italy and Sweden. Annual air pollution estimates of nitrogen oxides (NOx) at time of blood collection (1990-2006) were available from the ESCAPE study. In addition to univariate analysis and two variable selection methods to investigate the association between expression and exposure to NOx, we applied gene set enrichment analysis to assess overlap between our most perturbed genes and gene sets hypothesized to be related to air pollution and cigarette smoking. Finally, we assessed associations between NOx and CpG island methylation at the identified genes. Results: Annual average NOx exposure in the Italian and Swedish cohorts was 94.2 and 6.7 μg/m3, respectively. Long-Term exposure to NOx was associated with seven probes in the Italian cohort and one probe in the Swedish (and combined) cohorts. For genes AHCYL2 and MTMR2, changes were also seen in the methylo me. Genes hypothesized to be downregulated due to cigarette smoking were enriched among the most strongly downregulated genes from our study. Conclusion: This study provides evidence of subtle changes in gene expression related to exposure to long-Term NOx. On a global level, the observed changes in the transcriptome may indicate similarities between air pollution and tobacco induced changes in the transcriptome.
AU  - Mostafavi,N
AU  - Vlaanderen,J
AU  - Portengen,L
AU  - Chadeau-Hyam,M
AU  - Modig,L
AU  - Palli,D
AU  - Bergdahl,IA
AU  - Brunekreef,B
AU  - Vineis,P
AU  - Hebels,DGAJ
AU  - Kleinjans,JCS
AU  - Krogh,V
AU  - Hoek,G
AU  - Georgiadis,P
AU  - Kyrtopoulos,S
AU  - Vermeulena,R
DO  - 10.1097/EDE.0000000000000628
EP  - 328
PY  - 2017///
SN  - 1044-3983
SP  - 320
TI  - Associations between genome-wide gene expression and ambient nitrogen oxides
T2  - Epidemiology
UR  - http://dx.doi.org/10.1097/EDE.0000000000000628
UR  - http://hdl.handle.net/10044/1/48783
VL  - 28
ER  -

Download

ProfessorPaoloVineis

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)