Imperial College London
Alternate

ProfessorPaoloVineis

Faculty of Medicine, School of Public Health

Chair in Environmental Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
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Location

 

511Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chadeau:2017:10.1016/j.envint.2017.11.017,
author = {Chadeau, M and van, Veldhoven and Keski-Rahkonen, P and Barupal, DK and Villanueva, CM and Font-Ribera, L and Scalbert, A and Bodinier, B and Grimalt, JO and Zwiener, C and Vlaanderen, J and Portengen, L and Vermeulen, RCH and Vineis, P and Kogevinas, M},
doi = {10.1016/j.envint.2017.11.017},
journal = {Environment International},
pages = {60--70},
title = {Effects of exposure to water Disinfection By-Products in a swimming pool: A metabolome-wide association study},
url = {http://dx.doi.org/10.1016/j.envint.2017.11.017},
volume = {111},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundExposure to disinfection by-products (DBPs) in drinking water and chlorinated swimming pools are associated with adverse health outcomes, but biological mechanisms remain poorly understood.ObjectivesEvaluate short-term changes in metabolic profiles in response to DBP exposure while swimming in a chlorinated pool.Materials and methodsThe PISCINA-II study (EXPOsOMICS project) includes 60 volunteers swimming 40 min in an indoor pool. Levels of most common DBPs were measured in water and in exhaled breath before and after swimming. Blood samples, collected before and 2 h after swimming, were used for metabolic profiling by liquid-chromatography coupled to high-resolution mass-spectrometry. Metabolome-wide association between DBP exposures and each metabolic feature was evaluated using multivariate normal (MVN) models. Sensitivity analyses and compound annotation were conducted.ResultsExposure levels of all DBPs in exhaled breath were higher after the experiment. A total of 6,471 metabolic features were detected and 293 features were associated with at least one DBP in exhaled breath following Bonferroni correction. A total of 333 metabolic features were associated to at least one DBP measured in water or urine. Uptake of DBPs and physical activity were strongly correlated and mutual adjustment reduced the number of statistically significant associations. From the 293 features, 20 could be identified corresponding to 13 metabolites including compounds in the tryptophan metabolism pathway.ConclusionOur study identified numerous molecular changes following a swim in a chlorinated pool. While we could not explicitly evaluate which experiment-related factors induced these associations, molecular characterization highlighted metabolic features associated with exposure changes during swimming.
AU  - Chadeau,M
AU  - van,Veldhoven
AU  - Keski-Rahkonen,P
AU  - Barupal,DK
AU  - Villanueva,CM
AU  - Font-Ribera,L
AU  - Scalbert,A
AU  - Bodinier,B
AU  - Grimalt,JO
AU  - Zwiener,C
AU  - Vlaanderen,J
AU  - Portengen,L
AU  - Vermeulen,RCH
AU  - Vineis,P
AU  - Kogevinas,M
DO  - 10.1016/j.envint.2017.11.017
EP  - 70
PY  - 2017///
SN  - 0160-4120
SP  - 60
TI  - Effects of exposure to water Disinfection By-Products in a swimming pool: A metabolome-wide association study
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2017.11.017
UR  - http://hdl.handle.net/10044/1/53966
VL  - 111
ER  -
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