Publications
410 results found
Bondia J, Campos A, Diez JL, et al., 2015, BIHORMONAL ARTIFICIAL PANCREAS WITH COORDINATED INSULIN-GLUCAGON ACTION: A MULTIVARIABLE APPROACH TO GLYCEMIC CONTROL, Publisher: MARY ANN LIEBERT, INC, Pages: A19-A20, ISSN: 1520-9156
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- Citations: 1
Heaffey J, Koutsos E, Georgiou P, 2015, Wearable Device for Remote EMG and Muscle Fatigue Monitoring, 11th IEEE Annual Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 174-177, ISSN: 2163-4025
Moser N, Lande TS, Georgiou P, 2015, A Novel pH-to-Time ISFET Pixel Architecture with Offset Compensation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 481-484, ISSN: 0271-4302
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- Citations: 15
Spulber I, Chen Y-M, Papi E, et al., 2015, Live demonstration: Wearable electronics for a smart garment aiding rehabilitation, Pages: 1912-1912
Heaffey J, Koutsos E, Georgiou P, 2015, Live demonstration: Wearable device for remote EMG and muscle fatigue monitoring., Publisher: IEEE, Pages: 1-5
Heaffey J, Koutsos E, Georgiou P, 2015, Live Demonstration: Wearable Device for Remote EMG and Muscle Fatigue Monitoring, 11th IEEE Annual Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 173-173, ISSN: 2163-4025
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- Citations: 1
Hu Y, Georgiou P, 2014, 3-T ISFET front-end utilising parasitic device capacitance, ELECTRONICS LETTERS, Vol: 50, Pages: 1507-+, ISSN: 0013-5194
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- Citations: 8
Reddy M, Herrero P, El Sharkawy M, et al., 2014, Feasibility study of a bio-inspired artificial pancreas in adults with type 1 diabetes, Diabetes Technology and Therapeutics, Vol: 16, Pages: 550-557, ISSN: 1520-9156
Background: This study assesses proof of concept and safety of a novel bio-inspired artificial pancreas (BiAP) system in adults with type 1 diabetes during fasting, overnight, and postprandial conditions. In contrast to existing glucose controllers in artificial pancreas systems, the BiAP uses a control algorithm based on a mathematical model of β-cell physiology. The algorithm is implemented on a miniature silicon microchip within a portable hand-held device that interfaces the components of the artificial pancreas.Materials and Methods: In this nonrandomized open-label study each subject attended for a 6-h fasting study followed by a 13-h overnight and post-breakfast study on a separate occasion. During both study sessions the BiAP system was used, and microboluses of insulin were recommended every 5 min by the control algorithm according to subcutaneous sensor glucose levels. The primary outcome was percentage time spent in the glucose target range (3.9–10.0 mmol/L).Results: Twenty subjects (55% male; mean [SD] age, 44 [10] years; duration of diabetes, 22 [12] years; glycosylated hemoglobin, 7.4% [0.7%] [57 (7) mmol/mol]; body mass index, 25 [4] kg/m2) participated in the fasting study, and the median (interquartile range) percentage time in target range was 98.0% (90.8–100.0%). Seventeen of these subjects then participated in the overnight/postprandial study, where 70.7% (63.9–77.4%) of time was spent in the target range and, reassuringly, 0.0% (0.0–2.3%) of time was spent in hypoglycemia (<3.9 mmol/L).Conclusions: The BiAP achieves safe glycemic control during fasting, overnight, and postprandial conditions.
Reddy M, Agha-Jaffar R, Herrero P, et al., 2014, The impact of glycaemic variability on quality of life in adults with type1 diabetes, Publisher: SPRINGER, Pages: S429-S429, ISSN: 0012-186X
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- Citations: 7
Hu Y, Georgiou P, 2014, A robust ISFET pH-measuring front-end for chemical reaction monitoring, IEEE Transactions on Biomedical Circuits and Systems, Vol: 8, Pages: 177-185, ISSN: 1932-4545
This paper presents a robust, low-power and compact ion-sensitive field-effect transistor (ISFET) sensing front-end for pH reaction monitoring using unmodified CMOS. Robustness is achieved by overcoming problems of DC offset due to trapped charge and transcoductance reduction due to capacitive division, which commonly exist with implementation of ISFETs in CMOS. Through direct feedback to the floating gate and a low-leakage switching scheme, all the unwanted factors are eliminated while the output is capable of tracking a pH reaction which occurs at the sensing surface. This is confirmed through measured results of multiple devices of different sensing areas, achieving a mean amplification of 1.28 over all fabricated devices and pH sensitivity of 42.1 mV/pH. The front-end is also capable of compensating for accumulated drift using the designed switching scheme by resetting the floating gate voltage. The circuit has been implemented in a commercially-available 0.35 μm CMOS technology achieving a combined chemical and electrical output RMS noise of 3.1 mV at a power consumption of 848.1 nW which is capable of detecting pH changes as small as 0.06 pH.
Pagkalos I, Herrero P, Toumazou C, et al., 2014, Bio-Inspired Glucose Control in Diabetes Based on an Analogue Implementation of a β-Cell Model, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 8, Pages: 186-195, ISSN: 1932-4545
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- Citations: 13
Toumazou C, Thay TSLK, Georgiou P, 2014, A new era of semiconductor genetics using ion-sensitive field-effect transistors: the gene-sensitive integrated cell, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 372, ISSN: 1364-503X
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- Citations: 18
Herrero P, Liu C, Georgiou P, et al., 2014, HYPOGLYCEMIA PREDICTION BASED ON EXTENDED KALMAN FILTER USING A PHYSIOLOGICAL MODEL OF GLUCOSE REGULATION, Publisher: MARY ANN LIEBERT, INC, Pages: A82-A83, ISSN: 1520-9156
Reddy M, Oliver N, Herrero P, et al., 2014, THE IMPACT OF INSULIN INFUSION RATE VARIABILITY ON GLYCAEMIC VARIABILITY IN ADULTS WITH TYPE 1 DIABETES, Publisher: MARY ANN LIEBERT, INC, Pages: A59-A59, ISSN: 1520-9156
Reddy M, Oliver N, Herrero P, et al., 2014, GLYCAEMIC VARIABILITY AND QUALITY OF LIFE IN SUBJECTS WITH TYPE 1 DIABETES MELLITUS - IS THERE A CORRELATION?, Publisher: MARY ANN LIEBERT, INC, Pages: A59-A59, ISSN: 1520-9156
Pesl P, Herrero P, Reddy M, et al., 2014, Live Demonstration: An Advanced Bolus Calculator for Diabetes Management - A Clinical and Patient Platform, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 175-175, ISSN: 2163-4025
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- Citations: 2
Herrero P, El Sharkawy M, Pesl P, et al., 2014, Live Demonstration: A Handheld Bio-inspired Artificial Pancreas for Treatment of Diabetes, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 172-172, ISSN: 2163-4025
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- Citations: 3
Koutsos E, Georgiou P, 2014, An Analogue Instantaneous Median Frequency Tracker for EMG Fatigue Monitoring, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1388-1391, ISSN: 0271-4302
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- Citations: 9
Hu Y, Li J, Georgiou P, 2014, A SAR based calibration scheme for ISFET sensing arrays, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 666-669, ISSN: 0271-4302
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- Citations: 1
Spulber I, Papi E, Chen Y-M, et al., 2014, Development of a wireless multi-functional body sensing platform for smart garment integration, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 157-160, ISSN: 2163-4025
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- Citations: 3
El Sharkawy M, Georgiou P, 2014, A study of pancreatic β-cell coupling for improved glucose sensing, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 556-559, ISSN: 2163-4025
Reverter F, Prodromakis T, Liu Y, et al., 2014, Design Considerations for a CMOS Lab-on-Chip Microheater Array to Facilitate the in vitro Thermal Stimulation of Neurons, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 630-633
Bergmann JHM, Anastasova-Ivanova S, Spulber I, et al., 2013, An Attachable Clothing Sensor System for Measuring Knee Joint Angles, IEEE SENSORS JOURNAL, Vol: 13, Pages: 4090-4097, ISSN: 1530-437X
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- Citations: 47
Reddy M, Herrero P, Oliver N, et al., 2013, Clinical Evaluation of the Imperial College Bio-inspired Artificial Pancreas Overnight and After Breakfast in Adults with Type 1 Diabetes, European Association for the Study of Diabetes
Reverter F, Liu Y, Georgiou P, et al., 2013, Design Considerations for a CMOS Lab-on-Chip Microheater Array to Facilitate the in vitro Thermal Stimulation of Neurons, Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Publisher: IEEE
This paper identifies and addresses key designconsiderations and trade-offs in the implementation of a high resolution microheater array for CMOS Lab-on-Chip (LOC) applications. Specifically, this is investigated in the context of facilitating the in vitro thermal stimulation of single neurons. The paper analyses the electro-thermal response (by means of COMSOL simulations) and reliability issues (such as melting and electromigration) of different microheater designs. The analysis shows that a small-area heater is more efficient in terms of power, but it has more reliability problems essentially due to electromigration effects. For the proposed heater designs, the expected lifetime is a few days (in continuous operation) in the worst scenario, which is still generally acceptable for LOC applications.
Herrero P, Georgiou P, Oliver N, et al., 2013, A composite model of glucagon-glucose dynamics for in silico testing of bihormonal glucose controllers., J Diabetes Sci Technol, Vol: 7, Pages: 941-951
BACKGROUND: The utility of simulation environments in the development of an artificial pancreas for type 1 diabetes mellitus (T1DM) management is well established. The availability of a simulator that incorporates glucagon as a counterregulatory hormone to insulin would allow more efficient design of bihormonal glucose controllers. Existing models of the glucose regulatory system that incorporates glucagon action are difficult to identify without using tracer data. In this article, we present a novel model of glucagon-glucose dynamics that can be easily identified with standard clinical research data. METHODS: The minimal model of plasma glucose and insulin kinetics was extended to account for the action of glucagon on net endogenous glucose production by incorporating a new compartment. An existing subcutaneous insulin absorption model was used to account for subcutaneous insulin delivery. The same model of insulin pharmacokinetics was employed to model the pharmacokinetics of subcutaneous glucagon absorption. Finally, we incorporated an existing gastrointestinal absorption model to account for meal intake. Data from a closed-loop artificial pancreas study using a bihormonal controller on T1DM subjects were employed to identify the composite model. To test the validity of the proposed model, a bihormonal controller was designed using the identified model. RESULTS: Model parameters were identified with good precision, and an excellent fitting of the model with the experimental data was achieved. The proposed model allowed the design of a bihormonal controller and demonstrated its ability to improve glycemic control over a single-hormone controller. CONCLUSIONS: A novel composite model, which can be easily identified with standard clinical data, is able to account for the effect of exogenous insulin and glucagon infusion on glucose dynamics. This model represents another step toward the development of a bihormonal artificial pancreas.
Toumazou C, Shepherd LM, Reed S, et al., 2013, Simultaneous DNA amplification and detection using a pH-sensing semiconductor system, Nature Methods, Vol: 10, ISSN: 1548-7105
We developed an integrated chip for real-time amplification and detection of nucleic acid using pH-sensing complementary metal-oxide semiconductor (CMOS) technology. Here we show an amplification-coupled detection method for directly measuring released hydrogen ions during nucleotide incorporation rather than relying on indirect measurements such as fluorescent dyes. This is a label-free, non-optical, real-time method for detecting and quantifying target sequences by monitoring pH signatures of native amplification chemistries. The chip has ion-sensitive field effect transistor (ISFET) sensors, temperature sensors, resistive heating, signal processing and control circuitry all integrated to create a full system-on-chip platform. We evaluated the platform using two amplification strategies: PCR and isothermal amplification. Using this platform, we genotyped and discriminated unique single-nucleotide polymorphism (SNP) variants of the cytochrome P450 family from crude human saliva. We anticipate this semiconductor technology will enable the creation of devices for cost-effective, portable and scalable real-time nucleic acid analysis.
Georgiou P, Carrara S, 2013, Guest Editorial-ISCAS 2012 Special Issue, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 7, Pages: 105-106, ISSN: 1932-4545
Herrero P, Georgiou P, Oliver N, et al., 2013, In-Silico Comparison of a Bio-Inspired Glucose Controller vs. a PID controller with Insulin Feedback, Advanced Technologies & Treatments for Diabetes, 2013
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