Imperial College London

Dr Paras Anand

Faculty of MedicineDepartment of Medicine

Non-Clinical Lecturer in Infection
 
 
 
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Contact

 

+44 (0)20 3313 2063paras.anand Website

 
 
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Location

 

8.N23Commonwealth BuildingHammersmith Campus

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Summary

 

Summary

My research focuses on determining the functions and activation mechanisms of cytoplasmic Nod-like receptors (NLRs). NLRs modulate several anti-microbial functions including the activation of NF-kB and inflammasomes, a multimeric complex consisting of an NLR member together with adaptor ASC and pro-Caspase-1. The NLRP3 inflammasome has been extensively studied largely due to its’ roles in infectious and inflammatory disorders. However, the activation mechanisms of NLRP3 inflammasome remain ambiguous. We are interested in understanding how cellular metabolic pathways impact inflammasome activity. Our recent studies demonstrated cellular cholesterol transport as a key homeostatic mechanism regulating the NLRP3 inflammasome thereby highlighting a new perspective on the metabolic control of inflammasome. We are now interested in further characterizing the cholesterol transport pathways to decipher how they impact inflammasome activation and cellular metabolism, and whether these pathways might affect immune responses to pathogenic and ‘sterile’ stimuli. Our studies would lead to the identification of targets that calibrate immune responses to maintain cellular homeostasis.

A PhD position is currently available in the group. Please find more details here.

Selected Publications

Journal Articles

Hamilton C, Anand PK, 2019, Right place, right time: localisation and assembly of the NLRP3 inflammasome, F1000research, Vol:8, Pages:676-676

de la Roche M, Hamilton C, Mortensen R, et al., 2018, Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation, Journal of Cell Biology, Vol:217, ISSN:0021-9525, Pages:3560-3576

Hamilton C, Tan L, Miethke T, et al., 2017, Immunity to uropathogens: the emerging roles of inflammasomes, Nature Reviews Urology, Vol:14, ISSN:1759-4812, Pages:284-+

Lupfer C, Anand PK, 2016, Integrating Inflammasome Signaling in Sexually Transmitted Infections, Trends in Immunology, Vol:37, ISSN:1471-4906, Pages:703-714

Lupfer CR, Anand PK, Liu Z, et al., 2014, Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection, PLOS Pathogens, Vol:10, ISSN:1553-7366

Gurung P, Anand PK, Malireddi RKS, et al., 2014, FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes, Journal of Immunology, Vol:192, ISSN:0022-1767, Pages:1835-1846

Lupfer C, Thomas PG, Anand PK, et al., 2013, Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection, Nature Immunology, Vol:14, ISSN:1529-2908, Pages:480-+

Anand PK, Malireddi RKS, Lukens JR, et al., 2012, NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens, Nature, Vol:488, ISSN:0028-0836, Pages:389-+

Anand PK, Tait SWG, Lamkanfi M, et al., 2011, TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation, Journal of Biological Chemistry, Vol:286, ISSN:0021-9258, Pages:42981-42991

Kuehnel MP, Rybin V, Anand PK, et al., 2009, Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen, Journal of Cell Science, Vol:122, ISSN:0021-9533, Pages:499-504

More Publications