Publications
263 results found
Collins P, Webb C, 1999, Estrogen hits the surface, NATURE MEDICINE, Vol: 5, Pages: 1130-1131, ISSN: 1078-8956
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- Citations: 127
Figtree GA, Lu YQ, Webb CM, et al., 1999, Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism, CIRCULATION, Vol: 100, Pages: 1095-1101, ISSN: 0009-7322
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- Citations: 120
Schulze-Neick I, Penny DJ, Rigby ML, et al., 1999, L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery, CIRCULATION, Vol: 100, Pages: 749-755, ISSN: 0009-7322
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- Citations: 55
Hayward CS, Webb CM, Collins P, 1999, Hormone replacement therapy and heart-rate variability, LANCET, Vol: 354, Pages: 256-256, ISSN: 0140-6736
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- Citations: 3
Murray S, Carson KG, Ewings PD, et al., 1999, Spinal cord stimulation significantly decreases the need for acute hospital admission for chest pain in patients with refractory angina pectoris., Heart, Vol: 82, Pages: 89-92, ISSN: 1355-6037
OBJECTIVE: To assess the impact of spinal cord stimulation (SCS) on the need for acute admissions for chest pain in patients with refractory angina pectoris. DESIGN: Retrospective analysis of case records. PATIENTS: 19 consecutive patients implanted for SCS between 1987 and 1997. All had three vessel coronary disease, and all were in New York Heart Association functional group III/IV. METHODS: Admission rates were calculated for three separate periods: (1) from initial presentation up until last revascularisation; (2) from last revascularisation until SCS implantation; (3) from SCS implantation until the study date. Post-revascularisation rates were then compared with post-SCS rates, without including admissions before revascularisation, as this would bias against revascularisation procedures. RESULTS: Annual admission rate after revascularisation was 0.97/patient/year, compared with 0.27 after SCS (p = 0.02). Mean time in hospital/patient/year after revascularisation was 8.3 days v 2.5 days after SCS (p = 0.04). No unexplained new ECG changes were observed during follow up and patients presented with unstable angina and acute myocardial infarction in the usual way. CONCLUSIONS: SCS is effective in preventing hospital admissions in patients with refractory angina, without masking serious ischaemic symptoms or leading to silent infarction.
Webb CM, Adamson DL, de Zeigler D, et al., 1999, Effect of acute testosterone on myocardial ischemia in men with coronary artery disease, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 83, Pages: 437-+, ISSN: 0002-9149
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- Citations: 185
Collins P, 1999, The effect of estrogen on the coronary vasculature, 1st International Symposium on Estrogens and the Cardiovascular Systems, Publisher: PARTHENON PUBLISHING GROUP LTD, Pages: 21-31
Barrett-Connor E, Wenger NK, Grady D, et al., 1998, Coronary heart disease in women: Randomized clinical trials, HERS and RUTH, MATURITAS, Vol: 31, Pages: 1-7, ISSN: 0378-5122
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- Citations: 42
Crookes CIO, White PA, Staples M, et al., 1998, Myocardial contractility is not constant during spontaneous atrial fibrillation in patients, CIRCULATION, Vol: 98, Pages: 1762-1768, ISSN: 0009-7322
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- Citations: 57
Schulze-Neick I, Penny DJ, Rigby ML, et al., 1998, L-arginine and substance p reverse the pulmonary endothelial dysfunction after congenital heart surgery, CIRCULATION, Vol: 98, Pages: 547-547, ISSN: 0009-7322
Adamopoulos S, Rosano GMC, Ponikowski P, et al., 1998, Impaired baroreflex sensitivity and sympathovagal balance in syndrome X, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 82, Pages: 862-868, ISSN: 0002-9149
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- Citations: 30
Titley G, Collins PD, 1998, Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines., BMJ, Vol: 317, ISSN: 0959-8138
Allan L, Lamacraft G, Price CM, et al., 1998, Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy (multiple letters) [6], British Medical Journal, Vol: 317, Pages: 752-753, ISSN: 0959-8146
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- Citations: 2
Barrett-Connor E, Wenger NK, Grady D, et al., 1998, Hormone and nonhormone therapy for the maintenance of postmenopausal health: The need for randomized controlled trials of estrogen and raloxifene, JOURNAL OF WOMENS HEALTH, Vol: 7, Pages: 839-847, ISSN: 1540-9996
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- Citations: 55
Webb CM, Rosano GMC, Collins P, 1998, Oestrogen improves exercise-induced myocardial ischaemia in women, LANCET, Vol: 351, Pages: 1556-1557, ISSN: 0140-6736
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- Citations: 43
Murray S, Carson K, Collins PD, et al., 1998, Spinal Cord Stimulatiom (SCS) significantly reduces hospital re-admissions in patients with intractable angina pectoris, Heart, Vol: 79, ISSN: 1355-6037
Aim: SCS offers patients with intractable disease failing on standard therapy a safe and effective treatment. However, the implants are expensive (approx. £6000). In this retrospective study we looked at hospital admission rates both pre- and post- implant. Methods: We compared admissions in 19 patients implanted with SCS devices between 1989 to March 1997. Only admissions diagnosed as unstable angina or acute MI were looked at, and the length of stay calculated for each. Mean monthly admission rates were calculated for each individual. All results were tested with 2-tail t-tests. Patients: 14 male, 5 female all with 3 vessel disease as assessed on angiography. 12 (63%) with previous MI and 6 (31.6%) diabetics. 13 (68%) had previous CABG; 2 had previous angioplasty and 4 were not suitable for any revascularisation due to disease pattern. Results: The number of mean admissions was lower after implant (4.95 v 0.95, p=0.01), as were mean monthly admission rates (0.11 v 0.03, p=0.02). Mean number of admissions during the period post-CABG up until SCS implant, versus post-SCS implant also showed a significant decrease (3.26 v 0.89, p=0.04). The mean duration of admission per patient was 24.7 days after CABG versus 9.9 days after SCS. Post-implant admissions were mainly with severe unstable angina, and in 2 patients the device battery was found to be at "end of life". 2 others presented with acute MI. Unstable angina and MI presented in the usual way, and were not masked by SCS. Conclusions: SCS reduces re-admission rates in patients with severe intractable angina, but does not prevent usual presentation of acute coronary syndromes. This is in keeping with previous studies which have shown SCS to have an anti-ischaemic effect, rather than simply suppressing pain. Length of stay is also reduced, which may counter the initial expensive of the implant. It is therefore a useful and effective treatment in this group of patients in whom few options exist.
Webb CM, McNeill JG, Collins P, 1998, Testosterone increases coronary blood flow in men with coronary artery disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 2A-2A, ISSN: 0735-1097
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- Citations: 5
Webb CM, Underwood R, Anagnostopoulos C, et al., 1998, The effect of angiotensin converting enzyme inhibition on myocardial function and blood pressure after coronary artery bypass surgery - a randomised study, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 13, Pages: 42-48, ISSN: 1010-7940
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- Citations: 13
Rosano GMC, Caixeta AM, Chierchia S, et al., 1997, Short-term anti-ischemic effect of 17 beta-estradiol in postmenopausal women with coronary artery disease, CIRCULATION, Vol: 96, Pages: 2837-2841, ISSN: 0009-7322
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- Citations: 35
Webb CM, Rosano GMC, Collins P, 1997, Chronic estrogen therapy improves exercise time to myocardial ischemia in postmenopausal women with coronary artery disease, CIRCULATION, Vol: 96, Pages: 1731-1731, ISSN: 0009-7322
Beale CM, Rosano GMC, Collins P, 1997, Chronic estrogen therapy improves exercise time to myocardial ischemia in postmenopausal women with coronary artery disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 29, Pages: 7475-7475, ISSN: 0735-1097
Beale CM, Rosano GMC, Sontag G, et al., 1997, Effect of testosterone on coronary blood flow velocity to acetylcholine in men with coronary artery disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 29, Pages: 7856-7856, ISSN: 0735-1097
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- Citations: 1
Collins P, 1997, Angina in women, 2nd International Symposium on Womens Health in Menopause - Risk Reduction Strategies, Publisher: KLUWER ACADEMIC PUBL, Pages: 105-110
Beale CM, Rosano GM, Collins P, 1997, Testosterone induces coronary artery dilation in men with coronary artery disease., FERTILITY AND STERILITY, Pages: O019-O019, ISSN: 0015-0282
Rosano GMC, Peters NS, Lefroy D, et al., 1996, 17-Beta-estradiol therapy lessens angina in postmenopausal women with syndrome X, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 28, Pages: 1500-1505, ISSN: 0735-1097
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- Citations: 105
Beale CM, Collins P, 1996, The menopause and the cardiovascular system, BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY, Vol: 10, Pages: 483-513, ISSN: 0950-3552
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- Citations: 9
Rosano GM, Kaski JC, Arie S, et al., 1996, Failure to demonstrate myocardial ischaemia in patients with angina and normal coronary arteries. Evaluation by continuous coronary sinus pH monitoring and lactate metabolism., Eur Heart J, Vol: 17, Pages: 1175-1180, ISSN: 0195-668X
BACKGROUND: Whether myocardial ischaemia is the mechanism underlying chest pain in patients with angina and normal coronary arteriograms is controversial. We sought to detect the presence of transient myocardial ischaemia using continuous monitoring of coronary sinus blood pH during atrial pacing. METHODS AND RESULTS: We studied 14 patients (eight women, six men, mean age 51 +/- 3 years) with typical exertional angina and normal coronary arteriograms and nine patients with coronary artery disease (two men, seven women, mean age 61 +/- 7 years). Of the 14 patients with normal coronary arteries, eight had a reduced coronary blood flow reserve (< 2.5-fold increase), 11 had an ischaemic-appearing response to exercise testing, six had reversible perfusion detects on exercise thallium scans and one had resting left bundle branch block. All patients underwent continuous pH monitoring of coronary sinus blood at rest and during incremental atrial pacing (up to 160 bpm). Coronary sinus oxygen saturation and myocardial lactate extraction ratio were also evaluated at rest and at peak pacing. Eleven patients with angina and normal coronary arteries and eight with coronary artery disease had angina during pacing. Both patients with angina and normal coronary arteries (n = 13) and patients with coronary artery disease (n = 9) showed a fall in coronary sinus pH (-0.02 +/- 0.02 vs -0.11 +/- 0.03 pH units, respectively, P < 0.01). Coronary sinus oxygen saturation expressed as a percentage dropped by 19 +/- 6% in patients with coronary artery disease and by 6 +/- 2% in patients with angina and normal coronary arteriograms (P < 0.05). Myocardial lactate extraction ratio decreased from 33 +/- 6% to -1.4 +/- 4% in patients with coronary artery disease and from 23 +/- 8% to 20 +/- 8% in those with angina and normal coronary arteriograms. Three patients with angina and normal coronary arteries had a drop in coronary sinus pH > 0.02 pH units (-0.043 +/- 0.006 pH units) and in co
Collins P, 1996, Women and cardiovascular disease: The cardioprotective effects of ovarian hormones - Proceedings of a Symposium held on 25 August 1995 in Amsterdam, The Netherlands - Foreword, EUROPEAN HEART JOURNAL, Vol: 17, Pages: 1-1, ISSN: 0195-668X
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- Citations: 1
Rosano GMC, Chierchia SL, Leonardo F, et al., 1996, Cardioprotective effects of ovarian hormones, Symposium on Women and Cardiovascular Disease - The Cardioprotective Effects of Ovarian Hormones, Publisher: W B SAUNDERS CO LTD, Pages: 15-19, ISSN: 0195-668X
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- Citations: 35
Collins P, Beale CM, Rosano GMC, 1996, Oestrogen as a calcium channel blocker, EUROPEAN HEART JOURNAL, Vol: 17, Pages: 27-31, ISSN: 0195-668X
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- Citations: 31
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