Imperial College London
Alternate

ProfessorPeterCollins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8112peter.collins

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Krauskopf:2018:10.1016/j.envint.2018.01.014,
author = {Krauskopf, J and Caiment, F and van, Veldhoven K and Chadeau-Hyam, M and Sinharay, R and Chung, KF and Cullinan, P and Collins, P and de, Kok TM and Kelly, F and Vermeulen, R and Vineis, P and Kleinjans, JC},
doi = {10.1016/j.envint.2018.01.014},
journal = {Environment International},
pages = {26--34},
title = {The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution},
url = {http://dx.doi.org/10.1016/j.envint.2018.01.014},
volume = {113},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Traffic-related air pollution is a complex mixture of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide (NO2). PM exposure contributes to the pathogenesis of many diseases including several types of cancer, as well as pulmonary, cardiovascular and neurodegenerative diseases. Also exposure to NO2 has been related to increased cardiovascular mortality. In search of an early diagnostic biomarker for improved air pollution-associated health risk assessment, recent human studies have shown that certain circulating miRNAs are altered upon exposure to traffic-related air pollutants. Here, we present for the first time a global analysis of the circulating miRNA genome in an experimental cross-over study of a human population exposed to traffic-related air pollution. By utilizing next-generation sequencing technology and detailed real-time exposure measurements we identified 54 circulating miRNAs to be dose- and pollutant species-dependently associated with PM10, PM2.5, black carbon, ultrafine particles and NO2 already after 2h of exposure. Bioinformatics analysis suggests that these circulating miRNAs actually reflect the adverse consequences of traffic pollution-induced toxicity in target tissues including the lung, heart, kidney and brain. This study shows the strong potential of circulating miRNAs as novel biomarkers for environmental health risk assessment.
AU  - Krauskopf,J
AU  - Caiment,F
AU  - van,Veldhoven K
AU  - Chadeau-Hyam,M
AU  - Sinharay,R
AU  - Chung,KF
AU  - Cullinan,P
AU  - Collins,P
AU  - de,Kok TM
AU  - Kelly,F
AU  - Vermeulen,R
AU  - Vineis,P
AU  - Kleinjans,JC
DO  - 10.1016/j.envint.2018.01.014
EP  - 34
PY  - 2018///
SN  - 0160-4120
SP  - 26
TI  - The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2018.01.014
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29421404
UR  - https://www.sciencedirect.com/science/article/pii/S0160412017319827?via%3Dihub
UR  - http://hdl.handle.net/10044/1/56902
VL  - 113
ER  -
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