Imperial College London

Dr Peter Hellyer

Faculty of MedicineDepartment of Brain Sciences

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 9568peter.hellyer

 
 
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Location

 

4.35Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shanahan:2015:10.1523/JNEUROSCI.4648-14.2015,
author = {Shanahan, MP and Hellyer, P and Sharp, DJ and Scott, G and Leech, R},
doi = {10.1523/JNEUROSCI.4648-14.2015},
journal = {Journal of Neuroscience},
pages = {9050--9063},
title = {Cognitive flexibility through metastable neural dynamics is disrupted by damage to the structural connectome},
url = {http://dx.doi.org/10.1523/JNEUROSCI.4648-14.2015},
volume = {35},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Current theory proposes that healthy neural dynamics operate in a metastable regime, where brain regions interact to simultaneously maximize integration and segregation. Metastability may confer important behavioral properties, such as cognitive flexibility. It is increasingly recognized that neural dynamics are constrained by the underlying structural connections between brain regions. An important challenge is, therefore, to relate structural connectivity, neural dynamics, and behavior. Traumatic brain injury (TBI) is a pre-eminent structural disconnection disorder whereby traumatic axonal injury damages large-scale connectivity, producing characteristic cognitive impairments, including slowed information processing speed and reduced cognitive flexibility, that may be a result of disrupted metastable dynamics. Therefore, TBI provides an experimental and theoretical model to examine how metastable dynamics relate to structural connectivity and cognition. Here, we use complementary empirical and computational approaches to investigate how metastability arises from the healthy structural connectome and relates to cognitive performance. We found reduced metastability in large-scale neural dynamics after TBI, measured with resting-state functional MRI. This reduction in metastability was associated with damage to the connectome, measured using diffusion MRI. Furthermore, decreased metastability was associated with reduced cognitive flexibility and information processing. A computational model, defined by empirically derived connectivity data, demonstrates how behaviorally relevant changes in neural dynamics result from structural disconnection. Our findings suggest how metastable dynamics are important for normal brain function and contingent on the structure of the human connectome.
AU - Shanahan,MP
AU - Hellyer,P
AU - Sharp,DJ
AU - Scott,G
AU - Leech,R
DO - 10.1523/JNEUROSCI.4648-14.2015
EP - 9063
PY - 2015///
SN - 0270-6474
SP - 9050
TI - Cognitive flexibility through metastable neural dynamics is disrupted by damage to the structural connectome
T2 - Journal of Neuroscience
UR - http://dx.doi.org/10.1523/JNEUROSCI.4648-14.2015
UR - http://hdl.handle.net/10044/1/24009
VL - 35
ER -