Imperial College London

Dr Peter Hellyer

Faculty of MedicineDepartment of Brain Sciences

Honorary Lecturer



+44 (0)20 7594 9568peter.hellyer




4.35Royal School of MinesSouth Kensington Campus






BibTex format

author = {Hellyer, PJ and Barry, EF and Pellizzon, A and Veronese, M and Rizzo, G and Tonietto, M and Schütze, M and Brammer, M and Aurélio, Romano-Silva M and Bertoldo, A and Turkheimer, FE},
doi = {10.1016/j.neuroimage.2017.04.062},
journal = {Neuroimage},
pages = {209--216},
title = {Protein synthesis is associated with high-speed dynamics and broad-band stability of functional hubs in the brain.},
url = {},
volume = {155},
year = {2017}

RIS format (EndNote, RefMan)

AB - L-[1-(11)C]leucine PET can be used to measure in vivo protein synthesis in the brain. However, the relationship between regional protein synthesis and on-going neural dynamics is unclear. We use a graph theoretical approach to examine the relationship between cerebral protein synthesis (rCPS) and both static and dynamical measures of functional connectivity (measured using resting state functional MRI, R-fMRI). Our graph theoretical analysis demonstrates a significant positive relationship between protein turnover and static measures of functional connectivity. We compared these results to simple measures of metabolism in the cortex using [(18)F]FDG PET). Whilst some relationships between [(18)F]FDG binding and graph theoretical measures was present, there remained a significant relationship between protein turnover and graph theoretical measures, which were more robustly explained by L-[1-(11)C]Leucine than [(18)F]FDG PET. This relationship was stronger in dynamics at a faster temporal resolution relative to dynamics measured over a longer epoch. Using a Dynamic connectivity approach, we also demonstrate that broad-band dynamic measures of Functional Connectivity (FC), are inversely correlated with protein turnover, suggesting greater stability of FC in highly interconnected hub regions is supported by protein synthesis. Overall, we demonstrate that cerebral protein synthesis has a strong relationship independent of tissue metabolism to neural dynamics at the macroscopic scale.
AU - Hellyer,PJ
AU - Barry,EF
AU - Pellizzon,A
AU - Veronese,M
AU - Rizzo,G
AU - Tonietto,M
AU - Schütze,M
AU - Brammer,M
AU - Aurélio,Romano-Silva M
AU - Bertoldo,A
AU - Turkheimer,FE
DO - 10.1016/j.neuroimage.2017.04.062
EP - 216
PY - 2017///
SP - 209
TI - Protein synthesis is associated with high-speed dynamics and broad-band stability of functional hubs in the brain.
T2 - Neuroimage
UR -
UR -
UR -
VL - 155
ER -