Imperial College London

Dr Peter Hellyer

Faculty of MedicineDepartment of Brain Sciences

Honorary Lecturer



+44 (0)20 7594 9568peter.hellyer




4.35Royal School of MinesSouth Kensington Campus






BibTex format

author = {Chiou, SY and Hellyer, PJ and Sharp, DJ and Newbould, RD and Patel, MC and Strutton, PH},
doi = {10.1007/s00234-017-1869-0},
pages = {893--903},
title = {Relationships between the integrity and function of lumbar nerve roots as assessed by diffusion tensor imaging and neurophysiology},
url = {},
volume = {59},
year = {2017}

RIS format (EndNote, RefMan)

AB - PurposeDiffusion tensor imaging (DTI) has shown promise in the measurement of peripheral nerve integrity, although the optimal way to apply the technique for the study of lumbar spinal nerves is unclear. The aims of this study are to use an improved DTI acquisition to investigate lumbar nerve root integrity and correlate this with functional measures using neurophysiology.MethodsTwenty healthy volunteers underwent 3 T DTI of the L5/S1 area. Regions of interest were applied to L5 and S1 nerve roots, and DTI metrics (fractional anisotropy, mean, axial and radial diffusivity) were derived. Neurophysiological measures were obtained from muscles innervated by L5/S1 nerves; these included the slope of motor-evoked potential input-output curves, F-wave latency, maximal motor response, and central and peripheral motor conduction times.ResultsDTI metrics were similar between the left and right sides and between vertebral levels. Conversely, significant differences in DTI measures were seen along the course of the nerves. Regression analyses revealed that DTI metrics of the L5 nerve correlated with neurophysiological measures from the muscle innervated by it.ConclusionThe current findings suggest that DTI has the potential to be used for assessing lumbar spinal nerve integrity and that parameters derived from DTI provide quantitative information which reflects their function.
AU - Chiou,SY
AU - Hellyer,PJ
AU - Sharp,DJ
AU - Newbould,RD
AU - Patel,MC
AU - Strutton,PH
DO - 10.1007/s00234-017-1869-0
EP - 903
PY - 2017///
SN - 0028-3940
SP - 893
TI - Relationships between the integrity and function of lumbar nerve roots as assessed by diffusion tensor imaging and neurophysiology
UR -
UR -
UR -
VL - 59
ER -