Imperial College London

Dr Peter Hellyer

Faculty of MedicineDepartment of Brain Sciences

Honorary Lecturer



+44 (0)20 7594 9568peter.hellyer




4.35Royal School of MinesSouth Kensington Campus






BibTex format

author = {De, Simoni S and Jenkins, PO and Bourke, N and Fleminger, JJ and Hellyer, PJ and Jolly, AE and Patel, MC and Cole, J and Leech, R and Sharp, DJ},
doi = {brain/awx309},
journal = {Brain},
pages = {148--164},
title = {Altered caudate connectivity is associated with executive dysfunction after traumatic brain injury},
url = {},
volume = {141},
year = {2017}

RIS format (EndNote, RefMan)

AB - Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour and personality. Frontal lobe injuries are associated with executive dysfunction, but it is unclear how these injuries relate to corticostriatal interactions that are known to play an important role in behavioural control. We hypothesized that executive dysfunction after traumatic brain injury would be associated with abnormal corticostriatal interactions, a question that has not previously been investigated. We used structural and functional MRI measures of connectivity to investigate this. Corticostriatal functional connectivity in healthy individuals was initially defined using a data-driven approach. A constrained independent component analysis approach was applied in 100 healthy adult dataset from the Human Connectome Project. Diffusion tractography was also performed to generate white matter tracts. The output of this analysis was used to compare corticostriatal functional connectivity and structural integrity between groups of 42 patients with traumatic brain injury and 21 age-matched controls. Subdivisions of the caudate and putamen had distinct patterns of functional connectivity. Traumatic brain injury patients showed disruption to functional connectivity between the caudate and a distributed set of cortical regions, including the anterior cingulate cortex. Cognitive impairments in the patients were mainly seen in processing speed and executive function, as well as increased levels of apathy and fatigue. Abnormalities of caudate functional connectivity correlated with these cognitive impairments, with reductions in right caudate connectivity associated with increased executive dysfunction, information processing speed and memory impairment. Structural connectivity, measured using diffusion tensor imaging between the caudate and anterior cingulate cortex was impaired and this also correlated with measures of ex
AU - De,Simoni S
AU - Jenkins,PO
AU - Bourke,N
AU - Fleminger,JJ
AU - Hellyer,PJ
AU - Jolly,AE
AU - Patel,MC
AU - Cole,J
AU - Leech,R
AU - Sharp,DJ
DO - brain/awx309
EP - 164
PY - 2017///
SN - 1460-2156
SP - 148
TI - Altered caudate connectivity is associated with executive dysfunction after traumatic brain injury
T2 - Brain
UR -
UR -
VL - 141
ER -