Imperial College London

Dr Peter Hellyer

Faculty of MedicineDepartment of Brain Sciences

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 9568peter.hellyer

 
 
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Location

 

4.35Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{arora:2017:10.3389/fmats.2017.00041,
author = {arora, H and nila, A and Vitharana, K and sherwood, JM and nguyen, T-TN and Karunaratne, A and Mohammed, IK and bodey, A and hellyer, PJ and overby, DR and schroter, RC and hollis, D},
doi = {10.3389/fmats.2017.00041},
journal = {Frontiers in Materials},
title = {Microstructural consequences of blast lung injury characterised with digital volume correlation},
url = {http://dx.doi.org/10.3389/fmats.2017.00041},
volume = {4},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - This study focuses on microstructural changes that occur within the mammalian lung when subject to blast and how these changes influence strain distributions within the tissue. Shock tube experiments were performed to generate the blast injured specimens (cadaveric Sprague-Dawley rats). Blast overpressures of 100 and 180 kPa were studied. Synchrotron tomography imaging was used to capture volumetric image data of lungs. Specimens were ventilated using a custom-built system to study multiple inflation pressures during each tomography scan. These data enabled the first digital volume correlation (DVC) measurements in lung tissue to be performed. Quantitative analysis was performed to describe the damaged architecture of the lung. No clear changes in the microstructure of the tissue morphology were observed due to controlled low- to moderate-level blast exposure. However, significant focal sites of injury were observed using DVC, which allowed the detection of bias and concentration in the patterns of strain level. Morphological analysis corroborated the findings, illustrating that the focal damage caused by a blast can give rise to diffuse influence across the tissue. It is important to characterize the non-instantly fatal doses of blast, given the transient nature of blast lung in the clinical setting. This research has highlighted the need for better understanding of focal injury and its zone of influence (alveolar interdependency and neighboring tissue burden as a result of focal injury). DVC techniques show great promise as a tool to advance this endeavor, providing a new perspective on lung mechanics after blast.
AU - arora,H
AU - nila,A
AU - Vitharana,K
AU - sherwood,JM
AU - nguyen,T-TN
AU - Karunaratne,A
AU - Mohammed,IK
AU - bodey,A
AU - hellyer,PJ
AU - overby,DR
AU - schroter,RC
AU - hollis,D
DO - 10.3389/fmats.2017.00041
PY - 2017///
SN - 2296-8016
TI - Microstructural consequences of blast lung injury characterised with digital volume correlation
T2 - Frontiers in Materials
UR - http://dx.doi.org/10.3389/fmats.2017.00041
UR - http://hdl.handle.net/10044/1/54355
VL - 4
ER -