Imperial College London

Dr Peter Hellyer

Faculty of MedicineDepartment of Medicine

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 9568peter.hellyer

 
 
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Location

 

4.35Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nicola:2018:10.1063/1.5026489,
author = {Nicola, W and Hellyer, PJ and Campbell, SA and Clopath, C},
doi = {10.1063/1.5026489},
journal = {Chaos},
title = {Chaos in homeostatically regulated neural systems},
url = {http://dx.doi.org/10.1063/1.5026489},
volume = {28},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Low-dimensional yet rich dynamics often emerge in the brain. Examples include oscillations and chaotic dynamics during sleep, epilepsy, and voluntary movement. However, a general mechanism for the emergence of low dimensional dynamics remains elusive. Here, we consider Wilson-Cowan networks and demonstrate through numerical and analytical work that homeostatic regulation of the network firing rates can paradoxically lead to a rich dynamical repertoire. The dynamics include mixed-mode oscillations, mixed-mode chaos, and chaotic synchronization when the homeostatic plasticity operates on a moderately slower time scale than the firing rates. This is true for a single recurrently coupled node, pairs of reciprocally coupled nodes without self-coupling, and networks coupled through experimentally determined weights derived from functional magnetic resonance imaging data. In all cases, the stability of the homeostatic set point is analytically determined or approximated. The dynamics at the network level are directly determined by the behavior of a single node system through synchronization in both oscillatory and non-oscillatory states. Our results demonstrate that rich dynamics can be preserved under homeostatic regulation or even be caused by homeostatic regulation.When recordings from the brain are analyzed, rich dynamics such as oscillations or low-dimensional chaos are often present. However, a general mechanism for how these dynamics emerge remains unresolved. Here, we explore the potential that these dynamics are caused by an interaction between synaptic homeostasis, and the connectivity between distinct populations of neurons. Using both analytical and numerical approaches, we analyze how data derived connection weights interact with inhibitory synaptic homeostasis to create rich dynamics such chaos and oscillations operating on multiple time scales. We demonstrate that these rich dynamical states are present in simple systems such as single population of neurons
AU - Nicola,W
AU - Hellyer,PJ
AU - Campbell,SA
AU - Clopath,C
DO - 10.1063/1.5026489
PY - 2018///
SN - 1054-1500
TI - Chaos in homeostatically regulated neural systems
T2 - Chaos
UR - http://dx.doi.org/10.1063/1.5026489
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000443760700010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/64550
VL - 28
ER -