Imperial College London

ProfessorPetraHajkova

Faculty of MedicineInstitute of Clinical Sciences

Professor of Developmental Epigenetics
 
 
 
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Contact

 

+44 (0)20 3313 8264petra.hajkova Website

 
 
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Location

 

4006CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Summary

Epigenetic reprogramming encompasses changes in nuclear architecture and epigenetic modifications, eventually leading to a shift in gene expression profile. At the molecular level, such a process is connected with the erasure of epigenetic marks including DNA methylation and histone modifications. Our laboratory uses in vivo models to elucidate molecular mechanisms underlying naturally occurring reprogramming events. The knowledge gained allows us to design in vitro experimental systems and to use biochemical approaches to investigate further molecular details.

We study the reprogramming events both in the developing mouse germ line and in the mouse zygote. The former involves both genome-wide DNA demethylation and chromatin remodelling, whereas reprogramming the zygote involves genome-wide DNA demethylation affecting only the paternal genome a few hours after fertilisation.

As epigenetic reprogramming plays a pivotal role in the dedifferentiation and the reversal of cell fate decisions, investigation of molecular pathways underlying such processes provides direct mechanistic links to regeneration and cancer.

Publications

Journals

Cvetesic N, Borkowska M, Hatanaka Y, et al., 2020, Global regulatory transitions at core promoters demarcate the mammalian germline cycle

Zhu Q, Sang F, Withey S, et al., 2020, Specification and epigenetic resetting of the pig germline exhibit conservation with the human lineage

Yu C, Cvetesic N, Gupta K, et al., 2020, TBPL2/TFIIA complex overhauls oocyte transcriptome during oocyte growth

Catania S, Dumesic PA, Pimentel H, et al., 2020, Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de Novo methyltransferase, Cell, ISSN:0092-8674

Gillberg L, Orskov AD, Nasif A, et al., 2019, Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes, Clinical Epigenetics, Vol:11, ISSN:1868-7083, Pages:1-11

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