Imperial College London

Dr Robert Boyle

Faculty of MedicineDepartment of Medicine

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

222 results found

Biggs KV, Hurrell K, Matthews E, Khaleva E, Munblit D, Boyle RJet al., 2018, Formula Milk Supplementation on the Postnatal Ward: A Cross-Sectional Analytical Study, NUTRIENTS, Vol: 10, ISSN: 2072-6643

JOURNAL ARTICLE

Garcia-Larsen V, Ierodiakonou D, Jarrold K, Cunha S, Chivinge J, Robinson Z, Geoghegan N, Ruparelia A, Devani P, Trivella M, Leonardi-Bee J, Boyle RJet al., 2018, Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis, PLOS MEDICINE, Vol: 15, ISSN: 1549-1676

JOURNAL ARTICLE

Mavroudi A, Chrysochoou E-A, Boyle RJ, Trypsianis G, Xinias I, Cassimos D, Imvrios G, Katotomichelakis M, Karagiannidou A, Karantaglis N, Kourentas G, Warner JOet al., 2018, Validation of the Children's Sleep Habits Questionnaire in a sample of Greek children with allergic rhinitis., Allergol Immunopathol (Madr), Vol: 46, Pages: 389-393

BACKGROUND: Obstructive respiratory disorders, such as allergic rhinitis and asthma may impair sleep quality. The aim of this study is to validate the Children's Sleep Habits Questionnaire (CSHQ) for Greek children from 6 to 14 years of age. No validated tool has been developed so far to assess sleep disturbances in Greek school-aged children. METHODS: We examined the reliability and validity of the CSHQ in a sample of children with allergic rhinitis (AR) and a non-clinical population of parents of these children as a proxy measure of children's AR quality of life (QoL) as evaluated by the Pediatric Allergic Rhinitis Quality of Life (PedARQoL) questionnaire. RESULTS: The CSHQ questionnaire Child's Form (CF) had a moderate internal consistency with a Cronbach's alpha 0.671 and Guttman split-half coefficient of 0.563 when correlated with the PedARQoL (CF). There was also a moderate intraclass correlation of ICC=0.505 between the responses to both questionnaires in the two visits. The CSHQ Parent's Form (PF) had a very good internal consistency with a Cronbach's alpha of 0.928 and Guttman split-half coefficient of 0.798. There was a high intraclass correlation of 0.643 between the responses in the two visits. CONCLUSIONS: The Greek version of the CSHQ CF, but particularly the PF has proved to be a very reliable clinical instrument, which can be used in clinical trials for assessing sleep quality in school-aged children with sleep disturbances because of obstructive airway disorders, such as AR.

JOURNAL ARTICLE

Turner PJ, Campbell DE, Boyle RJ, Levin MEet al., 2018, Primary Prevention of Food Allergy: Translating Evidence from Clinical Trials to Population-Based Recommendations, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 6, Pages: 367-375, ISSN: 2213-2198

JOURNAL ARTICLE

Turner PJ, Garcia MR, Skypala IJ, Durham SR, Boyle RJ, Correia GDS, Pearce JTM, Holmes Eet al., 2018, CHANGES IN METABONOMIC PROFILE DURING PEANUT-INDUCED ANAPHYLAXIS AND CORRELATION WITH SYMPTOM, American-Academy-of-Allergy-Asthma-and-Immunology / World-Allergy-Organization Joint Congress, Publisher: MOSBY-ELSEVIER, Pages: AB85-AB85, ISSN: 0091-6749

CONFERENCE PAPER

Waidyatillake NT, Dharmage SC, Allen KJ, Bowatte G, Boyle RJ, Burgess JA, Koplin JJ, Garcia-Larsen V, Lowe AJ, Lodge CJet al., 2018, Association between the age of solid food introduction and eczema: A systematic review and a meta-analysis., Clin Exp Allergy

INTRODUCTION: Eczema is a common childhood ailment responsible for a considerable disease burden. Both timing of introduction to solid food and allergenic food are believed to be related to childhood eczema. Despite the growing body of evidence, the relationship between timing of any solid food introduction (allergenic and/or non-allergenic) and development of eczema has not previously been systematically reviewed. METHODS: PubMed and EMBASE databases were searched using food and eczema terms. Two authors selected papers according to the inclusion criteria and extracted information on study characteristics and measures of association. Meta-analyses were performed after grouping studies according to the age and type of exposure. RESULTS: A total of 17 papers met the inclusion criteria, reporting results from 16 study populations. Of these, 11 were cohort studies, 2 case-controls, 1 cross-sectional study and 2 randomized controlled trials. Limited meta-analyses were performed due to heterogeneity between studies. Timing of solid food introduction was not associated with eczema. One randomized controlled trial provided weak evidence of an association between early allergenic (around 4 months) food introduction and reduced risk of eczema. CONCLUSIONS: The available evidence is currently insufficient to determine whether the timing of introduction of any solid food influences the risk of eczema.

JOURNAL ARTICLE

Boyle RJ, Umasunthar T, Smith JG, Hanna H, Procktor A, Phillips K, Pinto C, Gore C, Cox HE, Warner JO, Vickers B, Hodes Met al., 2017, A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 1309-1317, ISSN: 0954-7894

JOURNAL ARTICLE

Cepeda AM, Thawer S, Boyle RJ, Villalba S, Jaller R, Tapias E, Segura AM, Villegas R, Garcia-Larsen Vet al., 2017, Diet and Respiratory Health in Children from 11 Latin American Countries: Evidence from ISAAC Phase III, LUNG, Vol: 195, Pages: 683-692, ISSN: 0341-2040

JOURNAL ARTICLE

Chalmers JR, Haines RH, Mitchell EJ, Thomas KS, Brown SJ, Ridd M, Lawton S, Simpson EL, Cork MJ, Sach TH, Bradshaw LE, Montgomery AA, Boyle RJ, Williams HCet al., 2017, Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial, TRIALS, Vol: 18, ISSN: 1745-6215

JOURNAL ARTICLE

Devani P, Ruparelia A, Garcia-Larsen V, Cunha S, Chivenge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Trivella M, Leonardi-Bee J, Boyle Ret al., 2017, Optimal mode of delivery for using probiotics or prebiotics to prevent eczema: a systematic review and meta-analysis, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY, Pages: 1700-1700, ISSN: 0954-7894

CONFERENCE PAPER

DunnGalvin A, Koman E, Raver E, Frome H, Adams M, Keena A, Hourihane JO, Gallagher PL, Flokstra-de Blok B, Dubois A, Pyrz K, Bindslev-Jensen C, Stensgaard A, Boyle R, Vickers B, Smith J, Thisanayagam U, Greenhawt Met al., 2017, An Examination of the Food Allergy Quality of Life Questionnaire Performance in a Countrywide American Sample of Children: Cross-Cultural Differences in Age and Impact in the United States and Europe, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 5, Pages: 363-+, ISSN: 2213-2198

JOURNAL ARTICLE

Ierodiakonou D, Garcia-Larsen V, Boyle RJ, 2017, Allergenic Food Introduction and Childhood Risk of Allergic or Autoimmune Disease Reply, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 317, Pages: 87-87, ISSN: 0098-7484

JOURNAL ARTICLE

Ierodiakonou D, Garcia-Larsen V, Boyle RJ, 2017, In reply, JAMA - Journal of the American Medical Association, Vol: 317, ISSN: 0098-7484

JOURNAL ARTICLE

Minshall E, Patel H, Francis N, Hansel TT, Warner JO, Boyle RJ, Fell J, Epstein Jet al., 2017, Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 28, Pages: 100-102, ISSN: 0905-6157

JOURNAL ARTICLE

Munblit D, Peroni DG, Boix-Amoros A, Hsu PS, Van't Land B, Gay MCL, Kolotilina A, Skevaki C, Boyle RJ, Collado MC, Garssen J, Geddes DT, Nanan R, Slupsky C, Wegienka G, Kozyrskyj AL, Warner JOet al., 2017, Human Milk and Allergic Diseases: An Unsolved Puzzle, NUTRIENTS, Vol: 9, ISSN: 2072-6643

JOURNAL ARTICLE

Munblit D, Treneva M, Peroni DG, Colicino S, Chow LY, Dissanayeke S, Pampura A, Boner AL, Geddes DT, Boyle RJ, Warner JOet al., 2017, Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis, NUTRIENTS, Vol: 9, ISSN: 2072-6643

JOURNAL ARTICLE

Roberts G, Boyle R, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JAet al., 2017, Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 1512-1525, ISSN: 0954-7894

JOURNAL ARTICLE

Ruparelia A, Devani P, Garcia-Larsen V, Ierodiakonou D, Cunha S, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Trivella M, Leonardi-Bee J, Boyle Ret al., 2017, Fatty acid supplementation during pregnancy, lactation or infancy and risk of allergic outcomes: A systematic review, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY, Pages: 1720-1720, ISSN: 0954-7894

CONFERENCE PAPER

Stiefel G, Anagnostou K, Boyle RJ, Brathwaite N, Ewan P, Fox AT, Huber P, Luyt D, Till SJ, Venter C, Clark ATet al., 2017, BSACI guideline for the diagnosis and management of peanut and tree nut allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 719-739, ISSN: 0954-7894

JOURNAL ARTICLE

Tang M, Rijnierse A, Nauta A, Boyle R, Hourihane J, Chiang W, Chua M, Smith P, Gold M, Ziegler J, Peake J, Quinn P, Rao R, Brown N, Garssen J, Warner Jet al., 2017, Influence of early feeding patterns on eczema development in high-risk infants, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY, Pages: 15-15, ISSN: 0105-4538

CONFERENCE PAPER

Turner PJ, Jerschow E, Umasunthar T, Lin R, Campbell DE, Boyle RJet al., 2017, Fatal Anaphylaxis: Mortality Rate and Risk Factors, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 5, Pages: 1169-1179, ISSN: 2213-2198

JOURNAL ARTICLE

Boyle RJ, Ierodiakonou D, Khan T, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Afxentiou T, Reeves T, Cunha S, Trivella M, Garcia-Larsen V, Leonardi-Bee Jet al., 2016, Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 1756-1833

JOURNAL ARTICLE

Boyle RJ, Tang ML-K, Chiang WC, Chua MC, Ismail I, Nauta A, Hourihane JO, Smith P, Gold M, Ziegler J, Peake J, Quinn P, Rao R, Brown N, Rijnierse A, Garssen J, Warner JOet al., 2016, Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial, ALLERGY, Vol: 71, Pages: 701-710, ISSN: 0105-4538

JOURNAL ARTICLE

Cepeda AM, Thawer A, Villalba SE, Jaller R, Tapias A, Segura AM, Boyle RJ, Garcia-Larsen Vet al., 2016, Dietary intake and allergies in Latin American children - evidence from ISAAC Phase III, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 99-99, ISSN: 0105-4538

CONFERENCE PAPER

Garcia Larsen V, Cepeda AM, Boyle RJ, Thawer S, Villalba SE, Joller R, Tapias A, Segura AM, Villegas Ret al., 2016, Dietary intake and allergies in Latin American children – Evidence from ISAAC Phase III, The European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress, Publisher: Wiley: 12 months, Pages: 98-98, ISSN: 1398-9995

CONFERENCE PAPER

Garcia RM, Belgrave D, Clark A, Skypala I, Durham S, Turner PJ, Boyle RJet al., 2016, Cardiac haemodynamic changes during acute IgE-mediated peanut allergic reactions in man, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 287-288, ISSN: 0105-4538

CONFERENCE PAPER

Garcia-Larsen V, Ierodiakonou D, Khan T, Afxentiou T, Leonardi-Bee J, Reeves T, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Andreou E, Cunha S, Trivella M, Boyle RJet al., 2016, Dietary exposures during pregnancy, lactation or infancy and risk of allergic diseases: a systematic review and meta-analysis, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 54-54, ISSN: 0105-4538

CONFERENCE PAPER

Hanna HJ, Emmanuel J, Naim S, Umasunthar T, Boyle RJet al., 2016, Community healthcare professionals overestimate the risk of fatal anaphylaxis for food allergic children, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 46, Pages: 1588-1595, ISSN: 0954-7894

JOURNAL ARTICLE

Ierodiakonou D, Garcia-Larsen V, Cunha S, Groome A, Logan A, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Trivella M, Leonardi-Bee J, Boyle Ret al., 2016, Timing of introduction of allergenic foods to the infant diet and risk of allergic and autoimmune diseases: a systematic review and meta-analysis, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 99-100, ISSN: 0105-4538

CONFERENCE PAPER

Ierodiakonou D, Garcia-Larsen V, Logan A, Groome A, Cunha S, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Tagiyeva-Milne N, Nurmatov U, Trivella M, Leonardi-Bee J, Boyle RJet al., 2016, Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease A Systematic Review and Meta-analysis, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 316, Pages: 1181-1192, ISSN: 0098-7484

JOURNAL ARTICLE

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