Imperial College London

Dr Robert Boyle

Faculty of MedicineDepartment of Medicine

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

162 results found

Boyle RJ, Umasunthar T, Smith JG, Hanna H, Procktor A, Phillips K, Pinto C, Gore C, Cox HE, Warner JO, Vickers B, Hodes Met al., 2017, A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial., Clin Exp Allergy, Vol: 47, Pages: 1309-1317

BACKGROUND: Mothers of children with food allergy have increased anxiety, which may be influenced by healthcare professionals' communication of risk. OBJECTIVE: To evaluate a brief psychological intervention for reducing anxiety in mothers of children with food allergy. METHODS: Two hundred mothers of children with food allergy were recruited from allergy clinics. A computer-generated randomization list was used to allocate participants to a single-session cognitive behavioural therapy intervention including a risk communication module, or standard care. Anxiety and risk perception were assessed at 6 weeks and 1 year. Primary outcome was state anxiety at 6 weeks. Secondary outcomes included state anxiety at 1 year, risk perception at 6 weeks and 1 year, and salivary cortisol response to a simulated anaphylaxis scenario at 1 year. RESULTS: We found no significant difference in the primary outcome state anxiety at 6 weeks, with mean 31.9 (SD 10.2) intervention, 34.0 (10.2) control; mean difference 2.1 (95% CI -0.9, 5.0; P=.17). There was significantly reduced state anxiety at 6 weeks in the intervention group, in the subgroup of participants with moderate/high anxiety at enrolment (103/200, 52%), with mean 33.0 (SD 9.3) intervention, 37.8 (SD 10.0) control; mean difference 4.8 (95% CI 0.9, 8.7; P=.016; Cohen's d effect size 0.50). The psychological intervention also reduced risk perception and salivary cortisol response (P=.032; effect size 0.36). CONCLUSION: We found evidence that a brief psychological intervention which incorporates accurate risk information may impact on anxiety, risk perception and physiological stress response in mothers of children with food allergy.

JOURNAL ARTICLE

Cepeda AM, Thawer S, Boyle RJ, Villalba S, Jaller R, Tapias E, Segura AM, Villegas R, Garcia-Larsen V, and the ISAAC Phase III Latin America Groupet al., 2017, Diet and Respiratory Health in Children from 11 Latin American Countries: Evidence from ISAAC Phase III., Lung

BACKGROUND AND AIM: The burden of childhood asthma and its risk factors is an important but neglected public health challenge in Latin America. We investigated the association between allergic symptoms and dietary intake in children from this region. METHODS: As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase III, questionnaire collected dietary intake was investigated in relation to risk of parental/child reported current wheeze (primary outcome) and rhino-conjunctivitis and eczema. Per-country adjusted logistic regressions were performed, and combined effect sizes were calculated with meta-analyses. RESULTS: 143,967 children from 11 countries had complete data. In children aged 6-7 years, current wheeze was negatively associated with higher fruit intake (adjusted odds ratio [aOR] 0.65; 95% CI 0.74, 0.97). Current rhino-conjunctivitis and eczema were statistically negatively associated with fruit intake (aOR 0.72; 95% CI 0.64, 0.82; and OR 0.64, 95% CI 0.56, 0.74, respectively). Vegetable intake was negatively associated with risk of symptoms in younger children, but these associations were attenuated in the 13-14 years old group. Fastfood/burger intake was positively associated with all three outcomes in the older children. CONCLUSION: A higher intake of fruits and vegetables was associated with a lower prevalence of allergic symptoms in Latin American children. Conversely, intake of fastfood was positively associated with a higher prevalence of wheeze in adolescents. Improved dietary habits in children might help reduce the epidemic of allergic symptoms in Latin America. Food interventions in asthmatic children are needed to evaluate the possible public health impact of a better diet on respiratory health.

JOURNAL ARTICLE

Chalmers JR, Haines RH, Mitchell EJ, Thomas KS, Brown SJ, Ridd M, Lawton S, Simpson EL, Cork MJ, Sach TH, Bradshaw LE, Montgomery AA, Boyle RJ, Williams HCet al., 2017, Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial, TRIALS, Vol: 18, ISSN: 1745-6215

JOURNAL ARTICLE

DunnGalvin A, Koman E, Raver E, Frome H, Adams M, Keena A, Hourihane JO, Gallagher PL, Flokstra-de Blok B, Dubois A, Pyrz K, Bindslev-Jensen C, Stensgaard A, Boyle R, Vickers B, Smith J, Thisanayagam U, Greenhawt Met al., 2017, An Examination of the Food Allergy Quality of Life Questionnaire Performance in a Countrywide American Sample of Children: Cross-Cultural Differences in Age and Impact in the United States and Europe, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 5, Pages: 363-+, ISSN: 2213-2198

JOURNAL ARTICLE

Ierodiakonou D, Garcia-Larsen V, Boyle RJ, 2017, Allergenic Food Introduction and Childhood Risk of Allergic or Autoimmune Disease Reply, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 317, Pages: 87-87, ISSN: 0098-7484

JOURNAL ARTICLE

Minshall E, Patel H, Francis N, Hansel TT, Warner JO, Boyle RJ, Fell J, Epstein Jet al., 2017, Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 28, Pages: 100-102, ISSN: 0905-6157

JOURNAL ARTICLE

Munblit D, Treneva M, Peroni DG, Colicino S, Chow LY, Dissanayeke S, Pampura A, Boner AL, Geddes DT, Boyle RJ, Warner JOet al., 2017, Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis, NUTRIENTS, Vol: 9, ISSN: 2072-6643

JOURNAL ARTICLE

Stiefel G, Anagnostou K, Boyle RJ, Brathwaite N, Ewan P, Fox AT, Huber P, Luyt D, Till SJ, Venter C, Clark ATet al., 2017, BSACI guideline for the diagnosis and management of peanut and tree nut allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 719-739, ISSN: 0954-7894

JOURNAL ARTICLE

Turner PJ, Jerschow E, Umasunthar T, Lin R, Campbell DE, Boyle RJet al., 2017, Fatal Anaphylaxis: Mortality Rate and Risk Factors, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 5, Pages: 1169-1179, ISSN: 2213-2198

JOURNAL ARTICLE

Boyle RJ, Ierodiakonou D, Khan T, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Afxentiou T, Reeves T, Cunha S, Trivella M, Garcia-Larsen V, Leonardi-Bee Jet al., 2016, Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 1756-1833

JOURNAL ARTICLE

Boyle RJ, Tang ML-K, Chiang WC, Chua MC, Ismail I, Nauta A, Hourihane JO, Smith P, Gold M, Ziegler J, Peake J, Quinn P, Rao R, Brown N, Rijnierse A, Garssen J, Warner JOet al., 2016, Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial, ALLERGY, Vol: 71, Pages: 701-710, ISSN: 0105-4538

JOURNAL ARTICLE

Cepeda AM, Thawer A, Villalba SE, Jaller R, Tapias A, Segura AM, Boyle RJ, Garcia-Larsen Vet al., 2016, Dietary intake and allergies in Latin American children - evidence from ISAAC Phase III, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 99-99, ISSN: 0105-4538

CONFERENCE PAPER

Garcia Larsen V, Cepeda AM, Boyle RJ, Thawer S, Villalba SE, Joller R, Tapias A, Segura AM, Villegas Ret al., 2016, Dietary intake and allergies in Latin American children – Evidence from ISAAC Phase III, The European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress, Publisher: Wiley: 12 months, Pages: 98-98, ISSN: 1398-9995

CONFERENCE PAPER

Garcia RM, Belgrave D, Clark A, Skypala I, Durham S, Turner PJ, Boyle RJet al., 2016, Cardiac haemodynamic changes during acute IgE-mediated peanut allergic reactions in man, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 287-288, ISSN: 0105-4538

CONFERENCE PAPER

Garcia-Larsen V, Ierodiakonou D, Khan T, Afxentiou T, Leonardi-Bee J, Reeves T, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Andreou E, Cunha S, Trivella M, Boyle RJet al., 2016, Dietary exposures during pregnancy, lactation or infancy and risk of allergic diseases: a systematic review and meta-analysis, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 54-54, ISSN: 0105-4538

CONFERENCE PAPER

Hanna HJ, Emmanuel J, Naim S, Umasunthar T, Boyle RJet al., 2016, Community healthcare professionals overestimate the risk of fatal anaphylaxis for food allergic children, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 46, Pages: 1588-1595, ISSN: 0954-7894

JOURNAL ARTICLE

Ierodiakonou D, Garcia-Larsen V, Cunha S, Groome A, Logan A, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Trivella M, Leonardi-Bee J, Boyle Ret al., 2016, Timing of introduction of allergenic foods to the infant diet and risk of allergic and autoimmune diseases: a systematic review and meta-analysis, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 99-100, ISSN: 0105-4538

CONFERENCE PAPER

Ierodiakonou D, Garcia-Larsen V, Logan A, Groome A, Cunha S, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Tagiyeva-Milne N, Nurmatov U, Trivella M, Leonardi-Bee J, Boyle RJet al., 2016, Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease A Systematic Review and Meta-analysis, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 316, Pages: 1181-1192, ISSN: 0098-7484

JOURNAL ARTICLE

Ismail IH, Boyle RJ, Licciardi PV, Oppedisano F, Lahtinen S, Robins-Browne RM, Tang MLKet al., 2016, Early gut colonization by Bifidobacterium breve and B. catenulatum differentially modulates eczema risk in children at high risk of developing allergic disease, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 27, Pages: 838-846, ISSN: 0905-6157

JOURNAL ARTICLE

Mavroudi A, Chrysochoou E-A, Boyle RJ, Papastergiopoulos A, Karantaglis N, Karagiannidou A, Xinias L, Farmaki E, Hatziagorou E, Kirvassilis F, Kourentas G, Tsanakas J, Warner JOet al., 2016, Validation study of the pediatric allergic rhinitis quality of life questionnarie, ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, Vol: 34, Pages: 159-165, ISSN: 0125-877X

JOURNAL ARTICLE

Mohseni YR, Turner PJ, Boyle RJ, Clark A, Robb AO, Durham SR, Shamji MHet al., 2016, Intracellular Expression of Fluorochrome Labelled-Diamine Oxidase in Basophils: A Novel Diagnostic Tool for Peanut Allergy, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB137-AB137, ISSN: 0091-6749

CONFERENCE PAPER

Munblit D, Sheth S, Abrol P, Treneva M, Peroni DG, Chow L-Y, Boner AL, Pampura A, Warner JO, Boyle RJet al., 2016, Exposures influencing total IgA level in colostrum, JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, Vol: 7, Pages: 61-67, ISSN: 2040-1744

JOURNAL ARTICLE

Munblit D, Treneva M, Peroni DG, Colicino S, Chow L, Dissanayeke S, Abrol P, Sheth S, Pampura A, Boner AL, Geddes DT, Boyle RJ, Warner JOet al., 2016, Colostrum and Mature Human Milk of Women from London, Moscow, and Verona: Determinants of Immune Composition, NUTRIENTS, Vol: 8, ISSN: 2072-6643

JOURNAL ARTICLE

Ntavli E, Turner PJ, Boyle RJ, Clark A, Robb AO, Durham SR, Shamji MHet al., 2016, Group 2 Innate Lymphoid Cells: New Players in Peanut Allergy, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB74-AB74, ISSN: 0091-6749

CONFERENCE PAPER

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JAet al., 2016, Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 46, Pages: 1248-1257, ISSN: 0954-7894

JOURNAL ARTICLE

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JAet al., 2016, Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 46, Pages: 1389-1397, ISSN: 0954-7894

JOURNAL ARTICLE

Ruiz-Garcia M, Hayward C, Tang A, Clark A, Skypala IJ, Durham SR, Lyon AR, Boyle RJ, Turner PJet al., 2016, Effects of Intramuscular Epinephrine on Cardiovascular Parameters during IgE-Mediated Allergic Reactions to Peanut, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB50-AB50, ISSN: 0091-6749

CONFERENCE PAPER

Smith TDH, Watt H, Gunn L, Car J, Boyle RJet al., 2016, Recommending Oral Probiotics to Reduce Winter Antibiotic Prescriptions in People With Asthma: A Pragmatic Randomized Controlled Trial, ANNALS OF FAMILY MEDICINE, Vol: 14, Pages: 422-430, ISSN: 1544-1709

JOURNAL ARTICLE

Tam H, Calderon MA, Manikam L, Nankervis H, Garcia Nunez I, Williams HC, Durham S, Boyle RJet al., 2016, Specific allergen immunotherapy for the treatment of atopic eczema, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

JOURNAL ARTICLE

Tam HH, Calderon MA, Manikam L, Nankervis H, Nunez IG, Williams HC, Durham SR, Boyle RJet al., 2016, Specific allergen immunotherapy for the treatment of atopic eczema: a Cochrane systematic review, ALLERGY, Vol: 71, Pages: 1345-1356, ISSN: 0105-4538

JOURNAL ARTICLE

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