Publications
375 results found
Tang A, Tattersall Z, Ruiz-Garcia M, et al., 2015, Assessment of cardiac changes during peanut allergic reactions, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 1891-1891, ISSN: 0954-7894
Tattersall Z, Tang A, Ruiz-Garcia M, et al., 2015, Assessment of the relationship between skin prick test reactivity, and severity and threshold of peanut allergic reaction in human volunteers, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 1891-1891, ISSN: 0954-7894
Umasunthar T, Leonardi-Bee J, Turner PJ, et al., 2015, Incidence of food anaphylaxis in people with food allergy: a systematic review and meta-analysis., Clinical & Experimental Allergy, Vol: 45, Pages: 1621-1636, ISSN: 1365-2222
BACKGROUND: Food allergy is a common cause of anaphylaxis, but the incidence of anaphylaxis in food allergic people is unknown. METHODS: We undertook a systematic review and meta-analysis, using the inverse variance method. Two authors selected studies by consensus, independently extracted data and assessed study quality using the Newcastle-Ottawa assessment scale. We searched Medline, Embase, PsychInfo, CINAHL, Web of Science, LILACS and AMED between January 1946 and September 2012, and recent conference abstracts. We included registries, databases or cohort studies which described the number of food anaphylaxis cases in a defined population and time period, and applied an assumed population prevalence of food allergy. RESULTS: We included data from 34 studies. There was high heterogeneity between study results, possibly due to variation in study populations, anaphylaxis definition and data collection methods. In food allergic people, medically-coded food anaphylaxis had an incidence rate of 0.14 per 100 person years (95% CI 0.05, 0.35; range 0.01, 1.28). In sensitivity analysis using different estimated food allergy prevalence, the incidence varied from 0.11 to 0.21 per 100 person years. At age 0-19 the incidence rate for anaphylaxis in food allergic people was 0.20 (95%CI 0.09, 0.43; range 0.01, 2.55; sensitivity analysis 0.08, 0.39). At age 0-4 an incidence rate of up to 7.00 per 100 person years has been reported. In food allergic people, hospital admission due to food anaphylaxis had an incidence rate of 0.09 (95% CI 0.01, 0.67; range 0.02, 0.81) per 1000 person years; 0.20 (95% CI 0.10, 0.43; range 0.04, 2.25) at age 0-19 and 0.50 (0.26, 0.93; range 0.08, 2.82) at age 0-4. CONCLUSION: In food allergic people, the incidence of food allergic reactions which are coded as anaphylaxis by healthcare systems is low at all ages, but appears to be highest in young children. This article is protected by copyright. All rights reserved.
Munblit D, Sheth S, Abrol P, et al., 2015, Exposures influencing total IgA level in colostrum, Journal of Developmental Origins of Health and Disease, Vol: 7, Pages: 61-67, ISSN: 2040-1744
Immunoglobulin A (IgA) is a predominant immunoglobulin present in human breast milk and is known to play an important role in infant gutimmunity maturation. Breast milk composition varies between populations, but the environmental and maternal factors responsible for thesevariations are still unclear. We examined the relationship between different exposures and levels of IgA in colostrum. The objective of this studywas to examine whether exposures analysed influence levels of IgA in colostrum. The present study used 294 colostrum samples from the MecMilkInternational cohort, collected from women residing in London, Moscow and Verona. Samples were analysed in automated Abbott ArchitectAnalyser. We found an inverse correlation between time postpartum and colostrum total IgA level (r = −0.49, P< 0.001). Adjusting for maternalparity, smoking, fresh fruit and fish consumption and allergen sensitization, multiple regression model showed that IgA levels were influenced bycolostrum collection time (P<0.0001) and country of collection (P< 0.01). Mode of delivery influence did not appear to be significant inunivariate comparisons, once adjusted for the above maternal characteristics it showed a significant influence on total IgA (P = 0.01).We conclude that the concentration of IgA in colostrum drops rapidly after birth and future studies should always consider this factor in analysis.IgA concentration varied significantly between countries, with the highest level detected in Moscow and lowest in Verona. Mode of delivery effectshould be confirmed on larger cohorts. Further work is needed to determine ways to correct for IgA decline over time in colostrum, and to find thecause of variations in IgA levels between the countries.
Munblit D, Treneva M, Peroni D, et al., 2015, Colostrum immune composition and immunological outcomes using principal component analysis (PCA), Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 111-111, ISSN: 0105-4538
Garcia RM, Wilson E, Clark A, et al., 2015, Cardiovascular haemodynamic changes during acute peanut allergic reactions in adults, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 32-33, ISSN: 0105-4538
Ruiz Garcia M, Hayward C, Sim M, et al., 2015, Electrocardiographic changes during acute peanut allergic reactions in adults, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 492-492, ISSN: 0105-4538
Dua S, Ruiz-Garcia M, Bond S, et al., 2015, Thresholds reactivity and clinical evaluation (TRACE) study: investigation of the effect of extrinsic factors on peanut allergic reactions, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 183-184, ISSN: 0105-4538
Turner PJ, Ruiz-Garcia M, Parkin R, et al., 2015, Basophil activation during - but not prior to - IgE-mediated allergic reactions to peanut correlates with symptom severity, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 48-48, ISSN: 0105-4538
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- Citations: 1
Ludman SW, Boyle RJ, 2015, Stinging insect allergy: current perspectives on venom immunotherapy, Journal of Asthma and Allergy, Vol: 8, Pages: 75-86, ISSN: 1178-6965
Systemic allergic reactions to insect stings affect up to 5% of the population during their lifetime, and up to 32% of beekeepers. Such reactions can be fatal, albeit very rarely, and fear of a further systemic reaction (SR) can lead to significant anxiety and quality of life impairment. A recent Cochrane systematic review confirmed that venom immunotherapy (VIT) is an effective treatment for people who have had a systemic allergic reaction to an insect sting. VIT reduces risk of a further SR (relative risk 0.10, 95% confidence interval 0.03-0.28), but VIT also reduces risk of a future large local reaction, and significantly improves disease-specific quality of life. However, health economic analysis showed that VIT is generally not cost effective for preventing future SRs; most people are stung infrequently, most SRs resolve without long-term consequences, and a fatal outcome is extremely rare. VIT only becomes cost effective if one is stung frequently (eg, beekeepers) or if quality of life improvement is considered. Thus, for most people with insect sting allergy, anxiety and quality of life impairment should be the overriding consideration when making treatment decisions, highlighting the importance of a patient-centered approach. Areas which need to be explored in future research include efforts to improve the safety and convenience of VIT such as the use of sublingual immunotherapy; quality of life effects of venom allergy in children and adolescents as well as their parents; and the optimal duration of treatment.
Umasunthar T, Procktor A, Hodes M, et al., 2015, Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial, ALLERGY, Vol: 70, Pages: 855-863, ISSN: 0105-4538
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- Citations: 45
Campbell DE, Boyle RJ, Thornton CA, et al., 2015, Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 45, Pages: 844-858, ISSN: 0954-7894
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- Citations: 49
Turner PJ, Gowland MH, Sharma V, et al., 2015, Increase in anaphylaxis-related hospitalizations but no increase in fatalities: An analysis of United Kingdom national anaphylaxis data, 1992-2012, Journal of Allergy and Clinical Immunology, Vol: 135, Pages: 956-963.e1, ISSN: 0091-6749
BackgroundThe incidence of anaphylaxis might be increasing. Data for fatal anaphylaxis are limited because of the rarity of this outcome.ObjectiveWe sought to document trends in anaphylaxis admissions and fatalities by age, sex, and cause in England and Wales over a 20-year period.MethodsWe extracted data from national databases that record hospital admissions and fatalities caused by anaphylaxis in England and Wales (1992-2012) and crosschecked fatalities against a prospective fatal anaphylaxis registry. We examined time trends and age distribution for fatal anaphylaxis caused by food, drugs, and insect stings.ResultsHospital admissions from all-cause anaphylaxis increased by 615% over the time period studied, but annual fatality rates remained stable at 0.047 cases (95% CI, 0.042-0.052 cases) per 100,000 population. Admission and fatality rates for drug- and insect sting–induced anaphylaxis were highest in the group aged 60 years and older. In contrast, admissions because of food-triggered anaphylaxis were most common in young people, with a marked peak in the incidence of fatal food reactions during the second and third decades of life. These findings are not explained by age-related differences in rates of hospitalization.ConclusionsHospitalizations for anaphylaxis increased between 1992 and 2012, but the incidence of fatal anaphylaxis did not. This might be due to increasing awareness of the diagnosis, shifting patterns of behavior in patients and health care providers, or both. The age distribution of fatal anaphylaxis varies significantly according to the nature of the eliciting agent, which suggests a specific vulnerability to severe outcomes from food-induced allergic reactions in the second and third decades.
Munblit D, Boyle RJ, Warner JO, 2015, Factors affecting breast milk composition and potential consequences for development of the allergic phenotype, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 45, Pages: 583-601, ISSN: 0954-7894
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- Citations: 44
Feketea G, Munblit D, Boyle RJ, 2015, Investigation of the relationship between maternal serum and breast milk levels of HGF (Hepatocyte Growth Factor), Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 509-509, ISSN: 0954-7894
Gore RB, Boyle RJ, Gore C, et al., 2015, Effect of a novel temperature-controlled laminar airflow device on personal breathing zone aeroallergen exposure, INDOOR AIR, Vol: 25, Pages: 36-44, ISSN: 0905-6947
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- Citations: 16
Turner PJ, McMahon O, Switzer A, et al., 2015, Marked Increase in Basophil Activation during Non-Anaphylactic Allergic Reactions to Peanut in Man, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB33-AB33, ISSN: 0091-6749
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- Citations: 3
Boyle RJ, Procktor A, Hodes M, et al., 2015, Epinephrine Autoinjector Use One Year after Training: A Randomised Controlled Comparison of Two Different Devices, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB209-AB209, ISSN: 0091-6749
Chivinge J, Ierodiakonou D, Leonardi-Bee J, et al., 2015, Probiotic supplementation for the prevention of eczema and allergic sensitisation: a systematic review, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 534-534, ISSN: 0954-7894
Nankervis H, Pynn EV, Boyle RJ, et al., 2015, House dust mite reduction and avoidance measures for treating eczema, Cochrane Database of Systematic Reviews, ISSN: 1469-493X
Blankestijn MA, Boyle RJ, Gore R, et al., 2014, Developments in the field of allergy in 2013 through the eyes of Clinical and Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 44, Pages: 1436-1457, ISSN: 0954-7894
Ismail IH, Boyle RJ, Mah L-J, et al., 2014, Reduced neonatal regulatory T cell response to microbial stimuli associates with subsequent eczema in high-risk infants, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 25, Pages: 674-684, ISSN: 0905-6157
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- Citations: 16
Robinson Z, Ierodiakonou D, Leonardi-Bee J, et al., 2014, Maternal intake of omega-3 fatty acids and risk of allergic diseases in the child: a systematic review and meta-analysis, British Society of Allergy and Clinical Immunology (BSACI) Annual Meeting
Jarrold K, Ierodiakonou D, Leonardi-Bee J, et al., 2014, Maternal and infant vitamin D exposure and risk of allergic or autoimmune Disease: A Systematic Review and meta-analysis, British Society of Allergy and Clinical Immunology (BSACI) Annual Meeting
Bakshi D, Hanna H, Gore R, et al., 2014, Analysis of changes in airborne pollutant levels in response to nocturnal temperature controlled laminar airflow treatment, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 454-454, ISSN: 0105-4538
Munblit D, Treneva M, Peroni D, et al., 2014, Difference in growth factor levels in colostrum and breast milk of mothers from Moscow, London and Verona, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 592-592, ISSN: 0105-4538
Boyle R, Warner JO, 2014, No relationship between biochemical measures of liver function and food sensitisation in infancy, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 381-381, ISSN: 0105-4538
Tang ML, Nauta A, Rijnierse A, et al., 2014, Hypo-antigenic and immune modulatory properties of a partially hydrolyzed cow's milk formula supplemented with prebiotic oligosaccharides, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 310-310, ISSN: 0105-4538
Nankervis H, Pynn EV, Boyle RJ, et al., 2014, House dust mite reduction and avoidance measures for treating eczema: a Cochrane review, 8th Georg Rajka Symposium on Atopic Dermatitis (ISAD), Publisher: WILEY-BLACKWELL, Pages: E50-E51, ISSN: 0007-0963
Chalmers JR, Thomas KS, Montgomery A, et al., 2014, A protocol for a randomized controlled trial to determine whether application of emollient from birth can prevent eczema in high-risk children (BEEP Trial), 8th Georg Rajka Symposium on Atopic Dermatitis (ISAD), Publisher: WILEY-BLACKWELL, Pages: E32-E32, ISSN: 0007-0963
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- Citations: 4
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