Imperial College London
Alternate

Dr Robert Boyle

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Munblit:2015:10.1017/S2040174415001476,
author = {Munblit, D and Sheth, S and Abrol, P and Treneva, M and Peroni, DG and Chow, L-Y and Boner, AL and Pampura, A and Warner, JO and Boyle, RJ},
doi = {10.1017/S2040174415001476},
journal = {Journal of Developmental Origins of Health and Disease},
pages = {61--67},
title = {Exposures influencing total IgA level in colostrum},
url = {http://dx.doi.org/10.1017/S2040174415001476},
volume = {7},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immunoglobulin A (IgA) is a predominant immunoglobulin present in human breast milk and is known to play an important role in infant gutimmunity maturation. Breast milk composition varies between populations, but the environmental and maternal factors responsible for thesevariations are still unclear. We examined the relationship between different exposures and levels of IgA in colostrum. The objective of this studywas to examine whether exposures analysed influence levels of IgA in colostrum. The present study used 294 colostrum samples from the MecMilkInternational cohort, collected from women residing in London, Moscow and Verona. Samples were analysed in automated Abbott ArchitectAnalyser. We found an inverse correlation between time postpartum and colostrum total IgA level (r = −0.49, P< 0.001). Adjusting for maternalparity, smoking, fresh fruit and fish consumption and allergen sensitization, multiple regression model showed that IgA levels were influenced bycolostrum collection time (P<0.0001) and country of collection (P< 0.01). Mode of delivery influence did not appear to be significant inunivariate comparisons, once adjusted for the above maternal characteristics it showed a significant influence on total IgA (P = 0.01).We conclude that the concentration of IgA in colostrum drops rapidly after birth and future studies should always consider this factor in analysis.IgA concentration varied significantly between countries, with the highest level detected in Moscow and lowest in Verona. Mode of delivery effectshould be confirmed on larger cohorts. Further work is needed to determine ways to correct for IgA decline over time in colostrum, and to find thecause of variations in IgA levels between the countries.
AU  - Munblit,D
AU  - Sheth,S
AU  - Abrol,P
AU  - Treneva,M
AU  - Peroni,DG
AU  - Chow,L-Y
AU  - Boner,AL
AU  - Pampura,A
AU  - Warner,JO
AU  - Boyle,RJ
DO  - 10.1017/S2040174415001476
EP  - 67
PY  - 2015///
SN  - 2040-1744
SP  - 61
TI  - Exposures influencing total IgA level in colostrum
T2  - Journal of Developmental Origins of Health and Disease
UR  - http://dx.doi.org/10.1017/S2040174415001476
VL  - 7
ER  -
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