Imperial College London
Alternate

Dr Robert Boyle

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ierodiakonou:2016:10.1001/jama.2016.12623,
author = {Ierodiakonou, D and Garcia, Larsen V and Logan, A and Groome, A and Cunha, S and Chivinge, J and Robinson, Z and Geoghegan, N and Jarrold, K and Reeves, T and Tagiyeva-Milne, N and Nurmatov, U and Trivella, M and Leonardi-Bee, J and Boyle, RJ},
doi = {10.1001/jama.2016.12623},
journal = {Journal of the American Medical Association},
pages = {1181--1192},
title = {Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease A Systematic Review and Meta-analysis},
url = {http://dx.doi.org/10.1001/jama.2016.12623},
volume = {316},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - mportance  Timing of introduction of allergenic foods to the infant diet may influence the risk of allergic or autoimmune disease, but the evidence for this has not been comprehensively synthesized.Objective  To systematically review and meta-analyze evidence that timing of allergenic food introduction during infancy influences risk of allergic or autoimmune disease.Data Sources  MEDLINE, EMBASE, Web of Science, CENTRAL, and LILACS databases were searched between January 1946 and March 2016.Study Selection  Intervention trials and observational studies that evaluated timing of allergenic food introduction during the first year of life and reported allergic or autoimmune disease or allergic sensitization were included.Data Extraction and Synthesis  Data were extracted in duplicate and synthesized for meta-analysis using generic inverse variance or Mantel-Haenszel methods with a random-effects model. GRADE was used to assess the certainty of evidence.Main Outcomes and Measures  Wheeze, eczema, allergic rhinitis, food allergy, allergic sensitization, type 1 diabetes mellitus, celiac disease, inflammatory bowel disease, autoimmune thyroid disease, and juvenile rheumatoid arthritis.Results  Of 16289 original titles screened, data were extracted from 204 titles reporting 146 studies. There was moderate-certainty evidence from 5 trials (1915 participants) that early egg introduction at 4 to 6 months was associated with reduced egg allergy (risk ratio [RR], 0.56; 95% CI, 0.36-0.87; I2 = 36%; P = .009). Absolute risk reduction for a population with 5.4% incidence of egg allergy was 24 cases (95% CI, 7-35 cases) per 1000 population. There was moderate-certainty evidence from 2 trials (1550 participants) that early peanut introduction at 4 to 11 months was associated with reduced peanut allergy (RR, 0.29; 95% CI, 0.11-0.74; I2 = 66%; P = .009). Absolute risk reduction for a population with 2.5% incidence of peanut allerg
AU  - Ierodiakonou,D
AU  - Garcia,Larsen V
AU  - Logan,A
AU  - Groome,A
AU  - Cunha,S
AU  - Chivinge,J
AU  - Robinson,Z
AU  - Geoghegan,N
AU  - Jarrold,K
AU  - Reeves,T
AU  - Tagiyeva-Milne,N
AU  - Nurmatov,U
AU  - Trivella,M
AU  - Leonardi-Bee,J
AU  - Boyle,RJ
DO  - 10.1001/jama.2016.12623
EP  - 1192
PY  - 2016///
SN  - 0002-9955
SP  - 1181
TI  - Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease A Systematic Review and Meta-analysis
T2  - Journal of the American Medical Association
UR  - http://dx.doi.org/10.1001/jama.2016.12623
UR  - http://hdl.handle.net/10044/1/40479
VL  - 316
ER  -
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