Imperial College London
Alternate

Dr Robert Boyle

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Munblit:2016:10.3390/nu8110695,
author = {Munblit, D and Treneva, M and Peroni, DG and Colicino, S and Chow, LY and Dissanayeke, S and Abrol, P and Sheth, S and Pampura, A and Boner, AL and Geddes, DT and Boyle, RJ and Warner, JO},
doi = {10.3390/nu8110695},
journal = {Nutrients},
title = {Colostrum and mature human milk of women from London, Moscow and Verona: determinants of immune composition},
url = {http://dx.doi.org/10.3390/nu8110695},
volume = {8},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cytokines and growth factors in colostrum and mature milk may play an important role in infant immune maturation, and may vary significantly between populations. We aimed to examine associations between environmental and maternal factors, and human milk (HM) cytokine and growth factor levels. We recruited 398 pregnant/lactating women in United Kingdom, Russia and Italy. Participants underwent skin prick testing, questionnaire interview, colostrum and mature milk sampling. HM cytokine and growth factor levels were quantified by electro-chemiluminescence. We found significant geographical variation in growth factor levels, but no evidence of variation between sites in cytokine detectability. There was an inverse correlation between time of milk sampling and growth factor levels in colostrum for HGF and TGFβ1; and 3 but not TGFβ2, and levels were significantly higher in colostrum than mature milk for all growth factors. The kinetics of decline were different for each growth factor. Cytokines were present at much lower levels than growth factors, and the decline over time was less consistent. HM growth factors and cytokine levels vary between populations for unknown reasons. Levels of HM mediators decline at different rates postpartum, and these findings suggest specific biological roles for HM growth factors and cytokines in early postnatal development.
AU  - Munblit,D
AU  - Treneva,M
AU  - Peroni,DG
AU  - Colicino,S
AU  - Chow,LY
AU  - Dissanayeke,S
AU  - Abrol,P
AU  - Sheth,S
AU  - Pampura,A
AU  - Boner,AL
AU  - Geddes,DT
AU  - Boyle,RJ
AU  - Warner,JO
DO  - 10.3390/nu8110695
PY  - 2016///
SN  - 2072-6643
TI  - Colostrum and mature human milk of women from London, Moscow and Verona: determinants of immune composition
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu8110695
UR  - http://www.mdpi.com/2072-6643/8/11/695/htm
UR  - http://hdl.handle.net/10044/1/42199
VL  - 8
ER  -
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