Imperial College London
Alternate

Dr Robert Boyle

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Garcia-Larsen:2018:10.1371/journal.pmed.1002507,
author = {Garcia-Larsen, V and Ierodiakonou, D and Jarrold, K and Cunha, S and Chivinge, J and Robinson, Z and Geoghegan, N and Ruparelia, A and Devani, P and Trivella, M and Leonardi-Bee, J and Boyle, RJ},
doi = {10.1371/journal.pmed.1002507},
journal = {PLoS Medicine},
title = {Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.1371/journal.pmed.1002507},
volume = {15},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:There is uncertainty about the influence of diet during pregnancy and infancy on a child’s immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease.Methods and findings:Two authors selected studies, extracted data, and assessed risk of bias. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess certainty of findings. We searched Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Web of Science, Central Register of Controlled Trials (CENTRAL), and Literatura Latino Americana em Ciências da Saúde (LILACS) between January 1946 and July 2013 for observational studies and until December 2017 for intervention studies that evaluated the relationship between diet during pregnancy, lactation, or the first year of life and future risk of allergic or autoimmune disease. We identified 260 original studies (964,143 participants) of milk feeding, including 1 intervention trial of breastfeeding promotion, and 173 original studies (542,672 participants) of other maternal or infant dietary exposures, including 80 trials of maternal (n = 26), infant (n = 32), or combined (n = 22) interventions. Risk of bias was high in 125 (48%) milk feeding studies and 44 (25%) studies of other dietary exposures. Evidence from 19 intervention trials suggests that oral supplementation with nonpathogenic micro-organisms (probiotics) during late pregnancy and lactation may reduce risk of eczema (Risk Ratio [RR] 0.78; 95% CI 0.68–0.90; I2 = 61%; Absolute Risk Reduction 44 cases per 1,000; 95% CI 20–64), and 6 trials suggest that fish oil supplementation during pregnancy and lactation may reduce risk of allergic sensitisation to egg (RR 0.69, 95% CI 0.53–0.90; I2 = 15%; Absolute Risk Reduction 31 cases per 1,000; 95% CI 10–47). GRADE certainty of these findings was moderate. We found weaker
AU  - Garcia-Larsen,V
AU  - Ierodiakonou,D
AU  - Jarrold,K
AU  - Cunha,S
AU  - Chivinge,J
AU  - Robinson,Z
AU  - Geoghegan,N
AU  - Ruparelia,A
AU  - Devani,P
AU  - Trivella,M
AU  - Leonardi-Bee,J
AU  - Boyle,RJ
DO  - 10.1371/journal.pmed.1002507
PY  - 2018///
SN  - 1549-1277
TI  - Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis
T2  - PLoS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1002507
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426459700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/58216
VL  - 15
ER  -
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