Imperial College London
Alternate

Dr Robert Boyle

Faculty of Medicine, National Heart & Lung Institute

Reader in Paediatric Allergy
 
 
 
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Contact

 

+44 (0)20 3312 7892r.boyle Website

 
 
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Location

 

Paediatric Research UnitQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Waidyatillake:2018:10.1111/cea.13140,
author = {Waidyatillake, NT and Dharmage, SC and Allen, K and Bowatte, G and Boyle, R and Burgess, J and Koplin, J and Garcia-Larsen, V and Lowe, AJ and Lodge, C},
doi = {10.1111/cea.13140},
journal = {Clinical and Experimental Allergy},
pages = {1000--1015},
title = {Association between the age of solid food introduction and eczema; a systematic review and a meta-analysis},
url = {http://dx.doi.org/10.1111/cea.13140},
volume = {48},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Eczema is a common childhood ailment responsible for a considerable disease burden. Both timing of introduction to solid food and allergenic food are believed to be related to childhood eczema. Despite the growing body of evidence, the relationship between timing of any solid food introduction (allergenic and/or non-allergenic) and development of eczema has not previously been systematically reviewed. METHODS: PubMed and EMBASE databases were searched using food and eczema terms. Two authors selected papers according to the inclusion criteria and extracted information on study characteristics and measures of association. Meta-analyses were performed after grouping studies according to the age and type of exposure. RESULTS: A total of 17 papers met the inclusion criteria, reporting results from 16 study populations. Of these, 11 were cohort studies, two case controls, one cross sectional study and, 2 randomised controlled trials. Limited meta-analyses were performed due to heterogeneity between studies. Timing of solid food introduction was not associated with eczema. One randomized controlled trial provided weak evidence of an association between early allergenic (around 4 months) food introduction and reduced risk of eczema. CONCLUSIONS: The available evidence is currently insufficient to determine whether the timing of introduction of any solid food influences the risk of eczema. This article is protected by copyright. All rights reserved.
AU  - Waidyatillake,NT
AU  - Dharmage,SC
AU  - Allen,K
AU  - Bowatte,G
AU  - Boyle,R
AU  - Burgess,J
AU  - Koplin,J
AU  - Garcia-Larsen,V
AU  - Lowe,AJ
AU  - Lodge,C
DO  - 10.1111/cea.13140
EP  - 1015
PY  - 2018///
SN  - 0954-7894
SP  - 1000
TI  - Association between the age of solid food introduction and eczema; a systematic review and a meta-analysis
T2  - Clinical and Experimental Allergy
UR  - http://dx.doi.org/10.1111/cea.13140
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29570230
UR  - http://hdl.handle.net/10044/1/58218
VL  - 48
ER  -
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