Prof. Rosemary Boyton is Head of Lung Immunology, Adult Infectious Disease, Department of Infectious Disease, Faculty of Medicine. Prof. Boyton works on the molecular immunology of infectious, allergic and autoimmune inflammation through patient based studies and TCR, HLA class II, lung targeted, inducible (Cre/Lox) and reporter transgenic models. Prof. Boyton studies the interplay between pathogen, host microbiota and innate and adaptive immune mechanisms in the regulation of inflammation.
Current research areas include: adaptive immunity in Zika virus and Chikungunya virus infection; adaptive immunity in infection with Burkholderia pseudomallei, B cepacia and B. multivorans, Pseudomonas aeruginosa and Aspergillus fumigatus; functional correlates of gut and lung microbiota and immune phenotype; lung autoimmunity; stem cells in chronic lung infection; regulation of NK cell responses by activating and inhibitory killer cell immunoglobulin-like (KIR) receptors and understanding how pathogen and self-peptide can modulate NK cell function through altering levels of NK cell activation/inhibition; the role of T cell receptor structure in effector function; correlates of protection in infection and vaccine studies.
Prof. Boyton is a Principal Investigator in the MRC & Asthma UK centre in Allergic Mechanisms of Asthma. Dr Boyton is on the editorial board of Clinical & Experimental Immunology. Prof. Boyton is a member of the Versus Arthritis UK College of Experts.
Prof. Boyton is an Honorary Consultant Physician in the Department of Respiratory Medicine at the Royal Brompton and Harefield NHS Foundation Trust. Prof. Boyton has specialist clinical expertise in lung infection (including Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, non-tuberculous mycobacteria (NTM), Aspergillus fumigatus), bronchiectasis and host immunity to infection.
The research is supported by the Medical Research Council (MRC), Biotechnological and Biological Sciences Research Council (BBSRC), Wellcome Trust, Innovate UK, National Institute of Allergy and Infectious Diseases (NIH NIAID), Asthma UK, MS Society, Versus Arthritis UK, Welton Foundation and NIHR.
With Professor Danny Altmann and Prof. Francois Balloux, Prof. Rosemary Boyton hosted a meeting at The Royal Society, London called "Human evolution, migration and history revealed by genetics, immunity and infection". This meeting offered a journey from molecules to history, bringing together geneticists, immunologists, anthropologists and historians. Infection has been the most potent evolutionary force in human history, eliminating genes offering poor resistance and selecting for new mutations conferring protection against a threat. The meeting addressed the issue of how genetics can help us understand natural selection, human evolution and migration over the past 70,000 years.
Philospohical Transactions of the Royal Society B. Biological Sciences. Volume 367. Issue 1590. Discussion meeting issue, 'Immunity, infection, migration and human evolution' organised and edited by Danny Altmann, Francois Balloux and Rosemary Boyton.
Speakers and Chairs included: Professor Mark Achtman, Professor Danny Altmann, Dr Kristian Andersen, Dr Francois Balloux, Professor Luigi Cavalli- Sforza, Professor Marc Feldmann FRS, Professor Marcelo Fernández-Viña, Dr Sebastien Gagneux, Professor Adrian Hill, Professor Nina Jablonski, Professor Mark Jobling, Professor John Novembre, Dr Stephen Oppenheimer, Professor Peter Parham FRS, Dr Alice Roberts, Professor Erik Thorsby, Professor Eske Willerslev, Dr Sarah Williams-Blangero
et al., 2019, Antibiotic therapy and outcome from immune-checkpoint inhibitors, Journal for Immunotherapy of Cancer, Vol:7, ISSN:2051-1426
Boyton RJ, Altmann DM, 2019, Muco-Obstructive Lung Diseases, New England Journal of Medicine, Vol:381, ISSN:0028-4793, Pages:E20-+
et al., The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4- induced inflammation during bacterial infection, Nature Microbiology, ISSN:2058-5276
et al., 2019, Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial, Gut, Vol:68, ISSN:0017-5749, Pages:1430-1438
et al., 2019, Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C., Proc Natl Acad Sci U S A, Vol:116, Pages:12964-12973