Prof. Rosemary Boyton is Head of the Lung Immunology. The mission of the Lung Immunology is to gain an understanding of the molecular interactions in T lymphocyte and NK cell responses leading to infectious, allergic and autoimmune disease.
Key research areas have included the role of T cell receptor (TCR) structure on T cell effector function; HLA-peptide modulation of NK cell function; and innate and adaptive immunity in the development and regulation of infectious and allergic inflammation.
Prof. Boyton has developed several TCR, lung targeted, inducible (Cre/Lox), and BAC reporter models to study the impact of TCR structure on T cell function and lung inflammation. Prof. Boyton studies innate and adaptive immune mechanisms in the development and regulation of pulmonary inflammation, airway hyperreactivity and airway remodeling in infection, allergy and autoimmunity.
Prof. Boyton is a Principal Investigator in the MRC & Asthma UK centre in Allergic Mechanisms of Asthma. Dr Boyton is on the editorial board of Clinical & Experimental Immunology and BMJ Open Respiratory Research. Prof. Boyton is a member of the Arthritis Research UK (ARUK) College of Experts.
Prof. Boyton is an Honorary Consultant Physician in the Department of Respiratory Medicine at the Royal Brompton and Harefield NHS Foundation Trust. Prof. Boyton has a speciatist interest in respiratory infection and host immunity to infection.
The research is supported by the Medical Research Council (MRC), Biotechnological and Biological Sciences Research Council (BBSRC), Wellcome Trust, National Institute of Allergy and Infectious Diseases (NIH NIAID), Asthma UK, MS Society, ARUK, Welton Foundation and NIHR.
With Professor Danny Altmann and Prof. Francois Balloux, Prof. Rosemary Boyton hosted a meeting at The Royal Society, London called "Human evolution, migration and history revealed by genetics, immunity and infection". This meeting offered a journey from molecules to history, bringing together geneticists, immunologists, anthropologists and historians. Infection has been the most potent evolutionary force in human history, eliminating genes offering poor resistance and selecting for new mutations conferring protection against a threat. The meeting addressed the issue of how genetics can help us understand natural selection, human evolution and migration over the past 70,000 years.
Philospohical Transactions of the Royal Society B. Biological Sciences. Volume 367. Issue 1590. Discussion meeting issue, 'Immunity, infection, migration and human evolution' organised and edited by Danny Altmann, Francois Balloux and Rosemary Boyton.
Speakers and Chairs included: Professor Mark Achtman, Professor Danny Altmann, Dr Kristian Andersen, Dr Francois Balloux, Professor Luigi Cavalli- Sforza, Professor Marc Feldmann FRS, Professor Marcelo Fernández-Viña, Dr Sebastien Gagneux, Professor Adrian Hill, Professor Nina Jablonski, Professor Mark Jobling, Professor John Novembre, Dr Stephen Oppenheimer, Professor Peter Parham FRS, Dr Alice Roberts, Professor Erik Thorsby, Professor Eske Willerslev, Dr Sarah Williams-Blangero
et al., 2014, Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile, BMC Biology, Vol:12, ISSN:1741-7007
et al., 2013, Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response, Acta Neuropathologica, Vol:126, ISSN:0001-6322, Pages:501-515