Imperial College London

ProfessorRosemaryBoyton

Faculty of MedicineDepartment of Infectious Disease

Professor of Immunology and Respiratory Medicine
 
 
 
//

Contact

 

r.boyton

 
 
//

Location

 

8N22Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Altmann:2004:10.1016/j.ddmod.2004.11.004,
author = {Altmann, DM and Boyton, RJ},
doi = {10.1016/j.ddmod.2004.11.004},
journal = {Drug Discovery Today: Disease Models},
pages = {405--410},
title = {Models of multiple sclerosis},
url = {http://dx.doi.org/10.1016/j.ddmod.2004.11.004},
volume = {1},
year = {2004}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Multiple sclerosis, the most common disease of central nervous system demyelination, is widely believed to result from autoimmune attack of myelin by T lymphocytes. Several approaches are widely used to model the disease. In vitro studies address specific steps in disease such as mechanisms of T-cell activation by myelin epitopes, migration across the blood-brain barrier and demyelination. In vivo models encompass approaches based on experimental allergic encephalomyelitis, as well as transgenic and mutant strains. Using these models, many therapeutic strategies have been proposed. © 2004 Elsevier Ltd. All rights reserved.
AU - Altmann,DM
AU - Boyton,RJ
DO - 10.1016/j.ddmod.2004.11.004
EP - 410
PY - 2004///
SN - 1740-6757
SP - 405
TI - Models of multiple sclerosis
T2 - Drug Discovery Today: Disease Models
UR - http://dx.doi.org/10.1016/j.ddmod.2004.11.004
VL - 1
ER -