Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Professor of Immunology and Respiratory Medicine







8N22Commonwealth BuildingHammersmith Campus






BibTex format

author = {Boyton, RJ and Altmann, D},
doi = {10.1146/annurev-pathol-012615-044344},
journal = {Annual Review of Pathology-Mechanisms of Disease},
pages = {523--554},
title = {Bronchiectasis: Current Concepts in Pathogenesis, Immunology, and Microbiology},
url = {},
volume = {11},
year = {2016}

RIS format (EndNote, RefMan)

AB - Bronchiectasis is a disorder of persistent lung inflammation and recurrent infection, defined by a common pathological end point: irreversible bronchial dilatation arrived at through diverse etiologies. This suggests an interplay between immunogenetic susceptibility, immune dysregulation, bacterial infection, and lung damage. The damaged epithelium impairs mucus removal and facilitates bacterial infection with increased cough, sputum production, and airflow obstruction. Lung infection is caused by respiratory bacterial and fungal pathogens, including Pseudomonas aeruginosa, Haemophilus, Aspergillus fumigatus, and nontuberculous mycobacteria. Recent studies have highlighted the relationship between the lung microbiota and microbial-pathogen niches. Disease may result from environments favoring interleukin-17-driven neutrophilia. Bronchiectasis may present in autoimmune disease, as well as conditions of immune dysregulation, such as combined variable immune deficiency, transporter associated with antigen processing–deficiency syndrome, and hyperimmunoglobulin E syndrome. Differences in prevalence across geography and ethnicity implicate an etiological mix of genetics and environment underpinning susceptibility.
AU - Boyton,RJ
AU - Altmann,D
DO - 10.1146/annurev-pathol-012615-044344
EP - 554
PY - 2016///
SN - 1553-4014
SP - 523
TI - Bronchiectasis: Current Concepts in Pathogenesis, Immunology, and Microbiology
T2 - Annual Review of Pathology-Mechanisms of Disease
UR -
VL - 11
ER -