Imperial College London
Alternate

ProfessorRosemaryBoyton

Faculty of Medicine, Department of Infectious Disease

Professor of Immunology and Respiratory Medicine
 
 
 
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Contact

 

r.boyton

 
 
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Location

 

8N22Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gregorova:2020:10.7554/eLife.63430,
author = {Gregorova, M and Morse, D and Brignoli, T and Steventon, J and Hamilton, F and Albur, M and Arnold, D and Thomas, M and Halliday, A and Baum, H and Rice, C and Avison, MB and Davidson, AD and Santopaolo, M and Oliver, E and Goenka, A and Finn, A and Wooldridge, L and Amulic, B and Boyton, RJ and Altmann, DM and Butler, DK and McMurray, C and Stockton, J and Nicholls, S and Cooper, C and Loman, N and Cox, MJ and Rivino, L and Massey, RC},
doi = {10.7554/eLife.63430},
journal = {eLife},
title = {Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia},
url = {http://dx.doi.org/10.7554/eLife.63430},
volume = {9},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Here we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.
AU  - Gregorova,M
AU  - Morse,D
AU  - Brignoli,T
AU  - Steventon,J
AU  - Hamilton,F
AU  - Albur,M
AU  - Arnold,D
AU  - Thomas,M
AU  - Halliday,A
AU  - Baum,H
AU  - Rice,C
AU  - Avison,MB
AU  - Davidson,AD
AU  - Santopaolo,M
AU  - Oliver,E
AU  - Goenka,A
AU  - Finn,A
AU  - Wooldridge,L
AU  - Amulic,B
AU  - Boyton,RJ
AU  - Altmann,DM
AU  - Butler,DK
AU  - McMurray,C
AU  - Stockton,J
AU  - Nicholls,S
AU  - Cooper,C
AU  - Loman,N
AU  - Cox,MJ
AU  - Rivino,L
AU  - Massey,RC
DO  - 10.7554/eLife.63430
PY  - 2020///
SN  - 2050-084X
TI  - Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.63430
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33331820
UR  - https://elifesciences.org/articles/63430
UR  - http://hdl.handle.net/10044/1/85203
VL  - 9
ER  -
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