Imperial College London
Alternate

ProfessorRosemaryBoyton

Faculty of Medicine, Department of Infectious Disease

Professor of Immunology and Respiratory Medicine
 
 
 
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Contact

 

r.boyton

 
 
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Location

 

8N22Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reynolds:2021:10.1126/science.abh1282,
author = {Reynolds, CJ and Pade, C and Gibbons, JM and Butler, DK and Otter, AD and Menacho, K and Fontana, M and Smit, A and Sackville-West, JE and Cutino-Moguel, T and Maini, MK and Chain, B and Noursadeghi, M and UK, COVIDsortium Immune Correlates Network and Brooks, T and Semper, A and Manisty, C and Treibel, TA and Moon, JC and UK, COVIDsortium Investigators and Valdes, AM and McKnight, Á and Altmann, DM and Boyton, R},
doi = {10.1126/science.abh1282},
journal = {Science},
pages = {1418--1423},
title = {Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose},
url = {http://dx.doi.org/10.1126/science.abh1282},
volume = {372},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants.
AU  - Reynolds,CJ
AU  - Pade,C
AU  - Gibbons,JM
AU  - Butler,DK
AU  - Otter,AD
AU  - Menacho,K
AU  - Fontana,M
AU  - Smit,A
AU  - Sackville-West,JE
AU  - Cutino-Moguel,T
AU  - Maini,MK
AU  - Chain,B
AU  - Noursadeghi,M
AU  - UK,COVIDsortium Immune Correlates Network
AU  - Brooks,T
AU  - Semper,A
AU  - Manisty,C
AU  - Treibel,TA
AU  - Moon,JC
AU  - UK,COVIDsortium Investigators
AU  - Valdes,AM
AU  - McKnight,Á
AU  - Altmann,DM
AU  - Boyton,R
DO  - 10.1126/science.abh1282
EP  - 1423
PY  - 2021///
SN  - 0036-8075
SP  - 1418
TI  - Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abh1282
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33931567
UR  - http://hdl.handle.net/10044/1/88889
VL  - 372
ER  -
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