Imperial College London
Alternate

ProfessorRosemaryBoyton

Faculty of Medicine, Department of Infectious Disease

Professor of Immunology and Respiratory Medicine
 
 
 
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Contact

 

r.boyton

 
 
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Location

 

8N22Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dunachie:2017:10.1038/s41598-017-12331-5,
author = {Dunachie, SJ and Jenjaroen, K and Reynolds, CJ and Quigley, KJ and Sergeant, R and Sumonwiriya, M and Chaichana, P and Chumseng, S and Ariyaprasert, P and Lassaux, P and Gourlay, L and Promwong, C and Teparrukkul, P and Limmathurotsakul, D and Day, NPJ and Altmann, DM and Boyton, RJ},
doi = {10.1038/s41598-017-12331-5},
journal = {SCIENTIFIC REPORTS},
title = {Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis},
url = {http://dx.doi.org/10.1038/s41598-017-12331-5},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Melioidosis, caused by Burkholderia pseudomallei, is a potentially lethal infection with no licensed vaccine. There is little understanding of why some exposed individuals have no symptoms, while others rapidly progress to sepsis and death, or why diabetes confers increased susceptibility. We prospectively recruited a cohort of 183 acute melioidosis patients and 21 control subjects from Northeast Thailand and studied immune parameters in the context of survival status and the presence or absence of diabetes. HLA-B46 (one of the commonest HLA class I alleles in SE Asia) and HLA-C01 were associated with an increased risk of death (odds ratio 2.8 and 3.1 respectively). Transcriptomic analysis during acute infection in diabetics indicated the importance of interplay between immune pathways including those involved in antigen presentation, chemotaxis, innate and adaptive immunity and their regulation. Survival was associated with enhanced T cell immunity to nine of fifteen immunodominant antigens analysed including AhpC (BPSL2096), BopE (BPSS1525), PilO (BPSS1599), ATP binding protein (BPSS1385) and an uncharacterised protein (BPSL2520). T cell immunity to GroEL (BPSL2697) was specifically impaired in diabetic individuals. This characterization of immunity associated with survival during acute infection offers insights into correlates of protection and a foundation for design of an effective multivalent vaccine.
AU  - Dunachie,SJ
AU  - Jenjaroen,K
AU  - Reynolds,CJ
AU  - Quigley,KJ
AU  - Sergeant,R
AU  - Sumonwiriya,M
AU  - Chaichana,P
AU  - Chumseng,S
AU  - Ariyaprasert,P
AU  - Lassaux,P
AU  - Gourlay,L
AU  - Promwong,C
AU  - Teparrukkul,P
AU  - Limmathurotsakul,D
AU  - Day,NPJ
AU  - Altmann,DM
AU  - Boyton,RJ
DO  - 10.1038/s41598-017-12331-5
PY  - 2017///
SN  - 2045-2322
TI  - Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis
T2  - SCIENTIFIC REPORTS
UR  - http://dx.doi.org/10.1038/s41598-017-12331-5
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000411434900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/53421
VL  - 7
ER  -
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