Imperial College London

Dr Robin Carhart-Harris

Faculty of MedicineDepartment of Medicine

Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
//

Assistant

 

Mrs Margaret Collett +44 (0)20 7594 7992

 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

62 results found

Carhart-Harris R, Lawton G, 2017, Trip advisor, NEW SCIENTIST, Vol: 235, Pages: 42-43, ISSN: 0262-4079

JOURNAL ARTICLE

Carhart-Harris RL, Erritzoe D, Haijen E, Kaelen M, Watts Ret al., 2017, Psychedelics and connectedness., Psychopharmacology (Berl)

Psychedelic drugs are creating ripples in psychiatry as evidence accumulates of their therapeutic potential. An important question remains unresolved however: how are psychedelics effective? We propose that a sense of connectedness is key, provide some preliminary evidence to support this, and suggest a roadmap for testing it further.

JOURNAL ARTICLE

Carhart-Harris RL, Goodwin GM, 2017, The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future, Neuropsychopharmacology, Vol: 42, Pages: 2105-2113, ISSN: 0893-133X

JOURNAL ARTICLE

Carhart-Harris RL, Nutt DJ, 2017, Serotonin and brain function: a tale of two receptors., J Psychopharmacol, Vol: 31, Pages: 1091-1120

Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-HT1A and 5-HT2A receptors. We propose that passive coping (i.e. tolerating a source of stress) is mediated by postsynaptic 5-HT1AR signalling and characterised by stress moderation. Conversely, we argue that active coping (i.e. actively addressing a source of stress) is mediated by 5-HT2AR signalling and characterised by enhanced plasticity (defined as capacity for change). We propose that 5-HT1AR-mediated stress moderation may be the brain's default response to adversity but that an improved ability to change one's situation and/or relationship to it via 5-HT2AR-mediated plasticity may also be important - and increasingly so as the level of adversity reaches a critical point. We propose that the 5-HT1AR pathway is enhanced by conventional 5-HT reuptake blocking antidepressants such as the selective serotonin reuptake inhibitors (SSRIs), whereas the 5-HT2AR pathway is enhanced by 5-HT2AR-agonist psychedelics. This bipartite model purports to explain how different drugs (SSRIs and psychedelics) that modulate the serotonergic system in different ways, can achieve complementary adaptive and potentially therapeutic outcomes.

JOURNAL ARTICLE

Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, Leech R, Curran HV, Nutt DJet al., 2017, Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms, Scientific Reports, Vol: 7, ISSN: 2045-2322

Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC. These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other ‘psychedelics’ yet were related to clinical outcomes. A ‘reset’ therapeutic mechanism is proposed.

JOURNAL ARTICLE

Erritzoe D, Nutt DJ, Carhart-Harris R, 2017, Concerns regarding conclusions made about LSD-treatments, HISTORY OF PSYCHIATRY, Vol: 28, Pages: 257-258, ISSN: 0957-154X

JOURNAL ARTICLE

Nour MM, Carhart-Harris RL, 2017, Psychedelics and the science of self-experience, BRITISH JOURNAL OF PSYCHIATRY, Vol: 210, Pages: 177-179, ISSN: 0007-1250

JOURNAL ARTICLE

Nour MM, Evans L, Carhart-Harris RL, 2017, Psychedelics, Personality and Political Perspectives, JOURNAL OF PSYCHOACTIVE DRUGS, Vol: 49, Pages: 182-191, ISSN: 0279-1072

JOURNAL ARTICLE

Schartner MM, Carhart-Harris RL, Barrett AB, Seth AK, Muthukumaraswamy SDet al., 2017, Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin, Scientific Reports, Vol: 7, Pages: 46421-46421

JOURNAL ARTICLE

Walpola IC, Nest T, Roseman L, Erritzoe D, Feilding A, Nutt DJ, Carhart-Harris RLet al., 2017, Altered Insula Connectivity under MDMA, NEUROPSYCHOPHARMACOLOGY, Vol: 42, Pages: 2152-2162, ISSN: 0893-133X

JOURNAL ARTICLE

Watts R, Day C, Krzanowski J, Nutt D, Carhart-Harris Ret al., 2017, Patients' Accounts of Increased "Connectedness" and "Acceptance" After Psilocybin for Treatment-Resistant Depression, JOURNAL OF HUMANISTIC PSYCHOLOGY, Vol: 57, Pages: 520-564, ISSN: 0022-1678

JOURNAL ARTICLE

Carhart-Harris R, 2016, 5-HT2A agonist drugs as new treatments in psychiatry, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S121-S121, ISSN: 0924-977X

CONFERENCE PAPER

Carhart-Harris RL, Bolstridge M, Rucker J, Day CMJ, Erritzoe D, Kaelen M, Bloomfield M, Rickard JA, Forbes B, Feilding A, Taylor D, Pilling S, Curran VH, Nutt DJet al., 2016, Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study, LANCET PSYCHIATRY, Vol: 3, Pages: 619-627, ISSN: 2215-0374

JOURNAL ARTICLE

Carhart-Harris RL, Kaelen M, Bolstridge M, Williams TM, Williams LT, Underwood R, Feilding A, Nutt DJet al., 2016, The paradoxical psychological effects of lysergic acid diethylamide (LSD), PSYCHOLOGICAL MEDICINE, Vol: 46, Pages: 1379-1390, ISSN: 0033-2917

JOURNAL ARTICLE

Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, Tagliazucchi E, Schenberg EE, Nest T, Orban C, Leech R, Williams LT, Williams TM, Bolstridge M, Sessa B, McGonigle J, Sereno MI, Nichols D, Hellyer PJ, Hobden P, Evans J, Singh KD, Wise RG, Curran HV, Feilding A, Nutt DJet al., 2016, Neural correlates of the LSD experience revealed by multimodal neuroimaging, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 4853-4858, ISSN: 0027-8424

JOURNAL ARTICLE

Carhart-Harris RL, Nutt DJ, 2016, Question-based Drug Development for psilocybin Reply, LANCET PSYCHIATRY, Vol: 3, Pages: 807-807, ISSN: 2215-0374

JOURNAL ARTICLE

Curran HV, Wall M, Demetriou L, Carhart-Harris R, Fergusson B, Nutt Det al., 2016, Effects of ecstasy on autobiographical memories: implications for MDMA assisted psychotherapy, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S145-S145, ISSN: 0924-977X

CONFERENCE PAPER

Family N, Vinson D, Vigliocco G, Kaelen M, Bolstridge M, Nutt DJ, Carhart-Harris RLet al., 2016, Semantic activation in LSD: evidence from picture naming, LANGUAGE COGNITION AND NEUROSCIENCE, Vol: 31, Pages: 1320-1327, ISSN: 2327-3798

JOURNAL ARTICLE

Kaelen M, Roseman L, Kahan J, Santos-Ribeiro A, Orban C, Lorenz R, Barrett FS, Bolstridge M, Williams T, Williams L, Wall MB, Feilding A, Muthukumaraswamy S, Nutt DJ, Carhart-Harris Ret al., 2016, LSD modulates music-induced imagery via changes in parahippocampal connectivity, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 26, Pages: 1099-1109, ISSN: 0924-977X

JOURNAL ARTICLE

Kaelen M, Roseman L, Lebedev A, Kahan J, Santos-Ribeiro A, Orban C, Lorenz R, Nutt D, Carhart-Harris Ret al., 2016, Effects of LSD and music on brain activity, ECNP Workshop for Junior Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S80-S81, ISSN: 0924-977X

CONFERENCE PAPER

Kaelen M, Roseman L, Lorenz R, Simmonds A, Santos-Ribeiro A, Nutt D, Carhart-Harris Ret al., 2016, Effects of LSD and music on brain activity, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S130-S130, ISSN: 0924-977X

CONFERENCE PAPER

Lebedev AV, Kaelen M, Lovden M, Nilsson J, Feilding A, Nutt DJ, Carhart-Harris RLet al., 2016, LSD-Induced Entropic Brain Activity Predicts Subsequent Personality Change, HUMAN BRAIN MAPPING, Vol: 37, Pages: 3203-3213, ISSN: 1065-9471

JOURNAL ARTICLE

Nour MM, Evans L, Nutt D, Carhart-Harris RLet al., 2016, Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI), FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 10, ISSN: 1662-5161

JOURNAL ARTICLE

Nutt D, Carhart-Harris RL, Curran H, 2016, Recent insights into the psychopharmacology of MDMA, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S145-S145, ISSN: 0924-977X

CONFERENCE PAPER

Roseman L, Sereno MI, Leech R, Kaelen M, Orban C, McGonigle J, Feilding A, Nutt DJ, Carhart-Harris RLet al., 2016, LSD Alters Eyes-Closed Functional Connectivity within the Early Visual Cortex in a Retinotopic Fashion, HUMAN BRAIN MAPPING, Vol: 37, Pages: 3031-3040, ISSN: 1065-9471

JOURNAL ARTICLE

Speth J, Speth C, Kaelen M, Schloerscheidt AM, Feilding A, Nutt DJ, Carhart-Harris RLet al., 2016, Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 30, Pages: 344-353, ISSN: 0269-8811

JOURNAL ARTICLE

Tagliazucchi E, Roseman L, Kaelen M, Orban C, Muthukumaraswamy SD, Murphy K, Laufs H, Leech R, McGonigle J, Crossley N, Bullmore E, Williams T, Bolstridge M, Feilding A, Nutt DJ, Carhart-Harris Ret al., 2016, Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution, CURRENT BIOLOGY, Vol: 26, Pages: 1043-1050, ISSN: 0960-9822

JOURNAL ARTICLE

Terhune DB, Luke DP, Kaelen M, Bolstridge M, Feilding A, Nutt D, Carhart-Harris R, Ward Jet al., 2016, A placebo-controlled investigation of synaesthesia-like experiences under LSD, NEUROPSYCHOLOGIA, Vol: 88, Pages: 28-34, ISSN: 0028-3932

JOURNAL ARTICLE

Carhart-Harris R, 2015, Results: Of a Multi-Modal Neuroimaging Study of LSD and a Psilocybin for Treatment-Resistant Depression Clinical Trial, 54th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Publisher: NATURE PUBLISHING GROUP, Pages: S91-S92, ISSN: 0893-133X

CONFERENCE PAPER

Carhart-Harris RL, Kaelen M, Whalley MG, Bolstridge M, Feilding A, Nutt DJet al., 2015, LSD enhances suggestibility in healthy volunteers, PSYCHOPHARMACOLOGY, Vol: 232, Pages: 785-794, ISSN: 0033-3158

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00604518&limit=30&person=true