Imperial College London
Alternate

Professor Robin Carhart-Harris

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
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Assistant

 

Miss Bruna Cunha +44 (0)20 7594 7992

 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kringelbach:2020:10.1073/pnas.1921475117,
author = {Kringelbach, ML and Cruzat, J and Cabral, J and Knudsen, GM and Carhart-Harris, R and Whybrow, PC and Logothetis, NK and Deco, G},
doi = {10.1073/pnas.1921475117},
journal = {Proceedings of the National Academy of Sciences of USA},
pages = {9566--9576},
title = {Dynamic coupling of whole-brain neuronal and neurotransmitter systems},
url = {http://dx.doi.org/10.1073/pnas.1921475117},
volume = {117},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to explain through long-term plasticity. Neuromodulation evolved to allow for such flexibility by dynamically updating the effectivity of the fixed anatomical connectivity. Here, we introduce a theoretical framework modeling the dynamical mutual coupling between the neuronal and neurotransmitter systems. We demonstrate that this framework is crucial to advance our understanding of whole-brain dynamics by bidirectional coupling of the two systems through combining multimodal neuroimaging data (diffusion magnetic resonance imaging [dMRI], functional magnetic resonance imaging [fMRI], and positron electron tomography [PET]) to explain the functional effects of specific serotoninergic receptor (5-HT2AR) stimulation with psilocybin in healthy humans. This advance provides an understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction. Overall, these insights demonstrate that the whole-brain mutual coupling between the neuronal and the neurotransmission systems is essential for understanding the remarkable flexibility of human brain function despite having to rely on fixed anatomical connectivity.
AU  - Kringelbach,ML
AU  - Cruzat,J
AU  - Cabral,J
AU  - Knudsen,GM
AU  - Carhart-Harris,R
AU  - Whybrow,PC
AU  - Logothetis,NK
AU  - Deco,G
DO  - 10.1073/pnas.1921475117
EP  - 9576
PY  - 2020///
SN  - 0027-8424
SP  - 9566
TI  - Dynamic coupling of whole-brain neuronal and neurotransmitter systems
T2  - Proceedings of the National Academy of Sciences of USA
UR  - http://dx.doi.org/10.1073/pnas.1921475117
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000530099500060&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.pnas.org/content/117/17/9566/tab-figures-data
UR  - http://hdl.handle.net/10044/1/84565
VL  - 117
ER  -
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